Ep. 600 “Breaking the ‘Limbic Lock’”– Why Your Brain Stalls in Healing and How to Fix It with Dr. Eboni Cornish |Menopause, Perimenopause, Brain Health

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

I’m delighted to connect with Dr. Eboni Cornish today. She is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society, specializing in complex chronic illness with expertise in brain health, Lyme disease, autoimmune conditions, mold exposure, gut dysfunction, and women’s midlife health.

In our conversation, we explore how perimenopause and menopause affect the brain, as well as the roles of genetics and epigenetics. Dr. Cornish explains limbic lock, SPECT imaging, the impact of tick-borne illnesses, and co-infections, and how brain health issues can influence mental health. We also dive into the role of mold in testing, the gut-brain-immune-hormone axis, vagal tone, the estrobolome, leptin, the MTHFR mutation, and how Dr. Cornish prefers to have it tested and treated in her patients.

Stay tuned for an insightful and wide-ranging conversation on brain health and women’s midlife wellness.

IN THIS EPISODE, YOU WILL LEARN:

  • Why women may experience brain fog, forgetfulness, and cognitive slowing as estrogen declines

  • How declining estrogen could make the brain more vulnerable to toxins, infections, and leaky brain

  • How disrupted sleep, poor nutrition, and lack of oxygen (from issues like sleep apnea) can negatively affect cognition and brain health

  • The value of continuing to learn and staying socially connected to support your cognitive health as you age

  • How genetics can help to identify women who may be at higher risk for cognitive decline later in life.

  • What limbic lock means

  • How toxin overload, mold, Lyme disease, and co-infections, and unresolved stress can create a state of limbic lock 

  • How SPECT imaging helps to explain why some people fail to improve despite multiple treatments

  • The benefits of progesterone for supporting relaxation and improving sleep during perimenopause

  • How declining estrogen and gut dysbiosis during perimenopause can affect the gut-brain axis

Bio: Dr. Eboni Cornish

Dr. Eboni Cornish is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society. She specializes in complex chronic illness, with expertise in brain health, Lyme disease, autoimmune conditions, mold toxicity, gut dysfunction, and women’s midlife health.

Known for her NeuroLongevity framework, Dr. Cornish takes a root-cause, brain-first approach to helping patients optimize cognitive resilience, hormone balance, and long-term wellness.

Connect with Cynthia Thurlow  

Connect with Dr. Eboni Cornish


More description

I’m delighted to connect with Dr. Eboni Cornish today. She is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society, specializing in complex chronic illness with expertise in brain health, Lyme disease, autoimmune conditions, mold exposure, gut dysfunction, and women’s midlife health.

In our conversation, we explore how perimenopause and menopause affect the brain, as well as the roles of genetics and epigenetics. Dr. Cornish explains limbic lock, SPECT imaging, the impact of tick-borne illnesses, and co-infections, and how brain health issues can influence mental health. We also dive into the role of mold in testing, the gut-brain-immune-hormone axis, vagal tone, the estrobolome, leptin, the MTHFR mutation, and how Dr. Cornish prefers to have it tested and treated in her patients.

Stay tuned for an insightful and wide-ranging conversation on brain health and women’s midlife wellness.

IN THIS EPISODE, YOU WILL LEARN:

  • Why women may experience brain fog, forgetfulness, and cognitive slowing as estrogen declines

  • How declining estrogen could make the brain more vulnerable to toxins, infections, and leaky brain

  • How disrupted sleep, poor nutrition, and lack of oxygen (from issues like sleep apnea) can negatively affect cognition and brain health

  • The value of continuing to learn and staying socially connected to support your cognitive health as you age

  • How genetics can help to identify women who may be at higher risk for cognitive decline later in life.

  • What limbic lock means

  • How toxin overload, mold, Lyme disease, and co-infections, and unresolved stress can create a state of limbic lock 

  • How SPECT imaging helps to explain why some people fail to improve despite multiple treatments

  • The benefits of progesterone for supporting relaxation and improving sleep during perimenopause

  • How declining estrogen and gut dysbiosis during perimenopause can affect the gut-brain axis

Bio: Dr. Eboni Cornish

Dr. Eboni Cornish is the Associate Medical Director of Amen Clinics and President of the International Lyme and Associated Diseases Society. She specializes in complex chronic illness, with expertise in brain health, Lyme disease, autoimmune conditions, mold toxicity, gut dysfunction, and women’s midlife health.

Known for her NeuroLongevity framework, Dr. Cornish takes a root-cause, brain-first approach to helping patients optimize cognitive resilience, hormone balance, and long-term wellness.

Connect with Cynthia Thurlow  

Connect with Dr. Eboni Cornish


2026-05-30 58 min
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