NFL Week 1 DraftKings Picks 2025 | Best DFS Lineups, Ownership & Pick’em Plays
NFL is back! In this video, Pat Mayo, Tyler Tamboline and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 1 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 1. Whether you’re entering GPPs or cash games, this guide has you covered.
FREE WEEK + 25% OFF NFL BETTING TOOLS & PACKAGES at https://www.4for4.com/mayo
$500K NFL Survivor ($50 Per Entry): https://bit.ly/mayo-survivor
Use code “MAYO” at underdog and make a $5 Pick’em entry and instantly get $50 in your account
Get a Deposit BONUS Coolbet: https://shorturl.at/CHfyW
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JOHNNIE WALKER — To claim a customized Blue Label Sunday Golf Bag by Devereux Go to johnniewalker.com/blue-in-water
BETTERHELP — Visit BetterHelp.com/PATMAYO today to get 10% off your first month.
CHUBBIES — Your new wardrobe awaits! Get $10 off @chubbies with the code MAYO at https://www.chubbiesshorts.com/MAYO #chubbiespod
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Show Index
00:00 Intro
00:41 TNF Takeaways
16:51 Week 1 DK Main Slate Overview
19:27 Optimal + CLE/CIN
42:11 MIA/IND
54:05 DEN Stack
59:51 WAS/NYG
1:07:46 ARZ/NO
Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369)
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More description
NFL is back! In this video, Pat Mayo, Tyler Tamboline and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 1 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 1. Whether you’re entering GPPs or cash games, this guide has you covered.
FREE WEEK + 25% OFF NFL BETTING TOOLS & PACKAGES at https://www.4for4.com/mayo
$500K NFL Survivor ($50 Per Entry): https://bit.ly/mayo-survivor
Use code “MAYO” at underdog and make a $5 Pick’em entry and instantly get $50 in your account
Get a Deposit BONUS Coolbet: https://shorturl.at/CHfyW
Subscribe, Rate and Review
Apple: http://bit.ly/PMEiTunes
Spotify: https://goo.gl/VboemH
#UDPartner
JOHNNIE WALKER — To claim a customized Blue Label Sunday Golf Bag by Devereux Go to johnniewalker.com/blue-in-water
BETTERHELP — Visit BetterHelp.com/PATMAYO today to get 10% off your first month.
CHUBBIES — Your new wardrobe awaits! Get $10 off @chubbies with the code MAYO at https://www.chubbiesshorts.com/MAYO #chubbiespod
FOLLOW MAYO MEDIA NETWORK
Newsletter: https://mayomedia.substack.com/
Instagram: https://www.instagram.com/mayomedianetwork/
TIK TOK: https://www.tiktok.com/discover/mayo-media-network
YOUTUBE: https://bit.ly/YTMMN
Show Index
00:00 Intro
00:41 TNF Takeaways
16:51 Week 1 DK Main Slate Overview
19:27 Optimal + CLE/CIN
42:11 MIA/IND
54:05 DEN Stack
59:51 WAS/NYG
1:07:46 ARZ/NO
Message and data rates apply. Must be 18+ (21+MA & AZ, 19+ AL, NE) and present in a state where Underdog Fantasy operates. Terms apply. Concerned with your play? Call 1-800-GAMBLER or visit www.ncpgambling.org; AZ: 1-800-NEXT-STEP (1-800-639-8783) or text NEXT-STEP to 53342; NY: Call the 24/7 HOPEline at 1-877-8-HOPENY or Text HOPENY (467369)
Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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