What makes jalapeños hot, and do they have other super powers?

#048

This week, Melissa and Jam dive into spiciness. What is it? Is it a flavor? Is it a feeling? Is it both? Is it more? Why can some people handle more than others? Does spiciness have any benefits?

We're proud to partner with MEL Science. Check out their home chemistry experiment sets here: bit.ly/melchem

References from this episode

1. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/vanilloids
2. Solomon’s Organic Chemistry 11th edition
3. Analogues of Capsaicin with Agonist Activity as Novel Analgesic agents; Structure-Activity Studies 2. The Amide Bond “B-Reigion” byWalpole et. al
4. Similarities and Differences in the Structure−Activity Relationships of Capsaicin and Resiniferatoxin Analogues by Walpole et. al
5. Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study by Ohbuchi et. al
6. The Art and Science of Organic andNatural Products Synthesis - by Nicolau et. al
7. https://www.acs.org/content/acs/en/pressroom/reactions/videos/2015/why-are-hot-peppers-hot-and-how-milk-helps.html

Thanks to our monthly supporters

• Ciara Linville
• J0HNTR0Y
• Jeannette Napoleon
• Cullyn R
• Erica Bee
• Elizabeth P
• Sarah Moar
• Rachel Reina
• Letila
• Katrina Barnum-Huckins
• Suzanne Phillips
• Nelly Silva
• Venus Rebholz
• Lyn Stubblefield
• Jacob Taber
• Brian Kimball
• Emerson Woodhall
• Kristina Gotfredsen
• Timothy Parker
• Steven Boyles
• Chris Skupien
• Chelsea B
• Bri McAllister
• Avishai Barnoy
• Hunter Reardon

Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.