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Casual Inference

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Keep it casual with the Casual Inference podcast. Your hosts Lucy D'Agostino McGowan and Ellie Murray talk all things epidemiology, statistics, data science, causal inference, and public health. Sponsored by the American Journal of Epidemiology.
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Keep it casual with the Casual Inference podcast. Your hosts Lucy D'Agostino McGowan and Ellie Murray talk all things epidemiology, statistics, data science, causal inference, and public health. Sponsored by the American Journal of Epidemiology.
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Episodes

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Follow Regression to the Mean Girls on [⁠Apple Podcasts⁠], [⁠Spotify⁠], or wherever you love to listen!


Christine Zhang⁠ (⁠New York Times⁠) joins ⁠⁠⁠Sarah Lotspeich⁠⁠⁠ and ⁠⁠⁠Lucy D'Agostino McGowan⁠⁠⁠⁠ with a data-driven side quest into the TV show Law and Order


Check out the full analysis here: ⁠⁠⁠regressiontothemeangirls.com⁠⁠⁠


Links to content we chat about on the episode:


Follow along on instagram: 

⁠@regressiontothemeangirls

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Follow Regression to the Mean Girls on [⁠Apple Podcasts⁠], [⁠Spotify⁠], or wherever you love to listen!


Christine Zhang⁠ (⁠New York Times⁠) joins ⁠⁠⁠Sarah Lotspeich⁠⁠⁠ and ⁠⁠⁠Lucy D'Agostino McGowan⁠⁠⁠⁠ with a data-driven side quest into the TV show Law and Order


Check out the full analysis here: ⁠⁠⁠regressiontothemeangirls.com⁠⁠⁠


Links to content we chat about on the episode:


Follow along on instagram: 

⁠@regressiontothemeangirls

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Follow Regression to the Mean Girls on [Apple Podcasts], [Spotify], or wherever you love to listen!


⁠Lucy D'Agostino McGowan⁠⁠ and ⁠⁠Sarah Lotspeich⁠⁠ return with a data-driven side quest into the TV show Severance. Lucy analyzes whether Milchick really uses more complicated language than his colleagues.


Check out the full analysis here: ⁠⁠regressiontothemeangirls.com⁠⁠


Links to content we chat about on the episode:


Follow along on instagram: 

@regressiontothemeangirls

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Follow Regression to the Mean Girls on [Apple Podcasts], [Spotify], or wherever you love to listen!


⁠Lucy D'Agostino McGowan⁠⁠ and ⁠⁠Sarah Lotspeich⁠⁠ return with a data-driven side quest into the TV show Severance. Lucy analyzes whether Milchick really uses more complicated language than his colleagues.


Check out the full analysis here: ⁠⁠regressiontothemeangirls.com⁠⁠


Links to content we chat about on the episode:


Follow along on instagram: 

@regressiontothemeangirls

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Sarah Lotspeich⁠ and ⁠Lucy D'Agostino McGowan⁠ introduce Regression to the Mean Girls, a podcast about data-driven side quests in pop culture. In this episode, Sarah analyzes 45 recent romance novels to find out how different romance tropes affect the timing of the couple’s first kiss.

Check out the full analysis here: ⁠https://regressiontothemeangirls.com/⁠


Links to content we chat about on the episode:


Follow along on instagram:

@regressiontothemeansgirls


Podcast feed: https://creators.spotify.com/pod/profile/rttmg/

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Sarah Lotspeich⁠ and ⁠Lucy D'Agostino McGowan⁠ introduce Regression to the Mean Girls, a podcast about data-driven side quests in pop culture. In this episode, Sarah analyzes 45 recent romance novels to find out how different romance tropes affect the timing of the couple’s first kiss.

Check out the full analysis here: ⁠https://regressiontothemeangirls.com/⁠


Links to content we chat about on the episode:


Follow along on instagram:

@regressiontothemeansgirls


Podcast feed: https://creators.spotify.com/pod/profile/rttmg/

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Emily Riederer is a Data Science Senior Manager at Credit Risk Modeling Capital One. Her website can be found here: https://www.emilyriederer.com/   Follow along on Bluesky:   🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Emily Riederer is a Data Science Senior Manager at Credit Risk Modeling Capital One. Her website can be found here: https://www.emilyriederer.com/   Follow along on Bluesky:   🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Carly Brantner is an assistant professor of Biostatistics & Bioinformatics at Duke University and Duke Clinical Research Institute.

Resources from this episode:
  • multicate: R package for estimating conditional average treatment effects across one or more studies using machine learning methods
  • PCORnet® Front Door: Access point for potential investigators, patient groups, and other stakeholders to connect with PCORnet and get support for potential research studies
  • Patient-Centered Outcomes Data Repository (PDOCR): De-identified data from 24 (and counting) PCORI-funded studies
Follow along on Bluesky:   🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Carly Brantner is an assistant professor of Biostatistics & Bioinformatics at Duke University and Duke Clinical Research Institute.

Resources from this episode:
  • multicate: R package for estimating conditional average treatment effects across one or more studies using machine learning methods
  • PCORnet® Front Door: Access point for potential investigators, patient groups, and other stakeholders to connect with PCORnet and get support for potential research studies
  • Patient-Centered Outcomes Data Repository (PDOCR): De-identified data from 24 (and counting) PCORI-funded studies
Follow along on Bluesky:   🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Andrew Heiss is an assistant professor in the Department of Public Management and Policy at the Andrew Young School of Policy Studies at Georgia State University. Follow along on Bluesky:   🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Andrew Heiss is an assistant professor in the Department of Public Management and Policy at the Andrew Young School of Policy Studies at Georgia State University. Follow along on Bluesky:   🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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In this episode Lucy and Ellie dig into a recently publicized paper, "Vaccination and Neurodevelopmental Disorders: A Study of Nine-Year-Old Children Enrolled in Medicaid", which has gained attention after being promoted by RFK Jr. as evidence that vaccines cause autism.   

Ellie breaks down her Substack critique of the study. Together, she and Lucy discuss the methodological flaws and what a better version of this study might look like.  

 

Follow along on Bluesky:

 

🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.

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In this episode Lucy and Ellie dig into a recently publicized paper, "Vaccination and Neurodevelopmental Disorders: A Study of Nine-Year-Old Children Enrolled in Medicaid", which has gained attention after being promoted by RFK Jr. as evidence that vaccines cause autism.   

Ellie breaks down her Substack critique of the study. Together, she and Lucy discuss the methodological flaws and what a better version of this study might look like.  

 

Follow along on Bluesky:

 

🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.

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Vincent Arel-Bundock is a professor at the Université de Montréal, where he studies comparative and international political economy.     Follow along on Bluesky:     🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Vincent Arel-Bundock is a professor at the Université de Montréal, where he studies comparative and international political economy.     Follow along on Bluesky:     🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.
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Noah Greifer is a statistical consultant and programmer at Harvard University.

Episode notes:

Follow along on Bluesky:

🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.

 

 

 

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Noah Greifer is a statistical consultant and programmer at Harvard University.

Episode notes:

Follow along on Bluesky:

🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.

 

 

 

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Lucy and Ellie chat about large language models, chat interfaces, and causal inference.

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🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.

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Lucy and Ellie chat about large language models, chat interfaces, and causal inference.

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🎶 Our intro/outro music is courtesy of Joseph McDade. Edited by Cameron Bopp.

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Lucy chats with Len Testa about a recent analysis he did which combined over 150 publicly available data sources to answer a question about the affordability of Disney World.

  • Len's Deep Dive Post on the Touring Plans Blog [Blog Post]
  • Wall Street Journal Artcile, "Even Disney Is Worried About the High Cost of a Disney Vacation" [Article]

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🎶 Our intro/outro music is courtesy of Joseph McDade

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Lucy chats with Len Testa about a recent analysis he did which combined over 150 publicly available data sources to answer a question about the affordability of Disney World.

  • Len's Deep Dive Post on the Touring Plans Blog [Blog Post]
  • Wall Street Journal Artcile, "Even Disney Is Worried About the High Cost of a Disney Vacation" [Article]

Follow along on Bluesky:

🎶 Our intro/outro music is courtesy of Joseph McDade

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Alyssa Bilinski, Peterson Family Assistant Professor of Health Policy, and Assistant Professor of Biostatistics, at Brown University School of Public Health. Her research focuses on developing novel methods for policy evaluation and applying these to identify interventions that most efficiently improve population health and well-being.

Episode notes:

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Alyssa Bilinski, Peterson Family Assistant Professor of Health Policy, and Assistant Professor of Biostatistics, at Brown University School of Public Health. Her research focuses on developing novel methods for policy evaluation and applying these to identify interventions that most efficiently improve population health and well-being.

Episode notes:

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Edward Kennedy Associate Professor, Department of Statistics & Data Science, Carnegie Mellon.

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🎶 Our intro/outro music is courtesy of Joseph McDade
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Edward Kennedy Associate Professor, Department of Statistics & Data Science, Carnegie Mellon.

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Sheree Bekker & Stephen Mumford are Co-directors of the Feminist Sport Lab and have a book coming soon: "Open Play: the case for feminist sport", coming Spring 2025. Reaktion Books (UK), University of Chicago Press (US).

Sheree Bekker: Associate Professor, University of Bath, Department for Health,

Stephen Mumford, Professor of Metaphysics, Durham University  A

  • Author of Dispositions (Oxford, 1998), Russell on Metaphysics (Routledge, 2003), Laws in Nature (Routledge, 2004), David Armstrong (Acumen, 2007), Watching Sport: Aesthetics, Ethics and Emotion (Routledge, 2011), Getting Causes from Powers (Oxford, 2011 with Rani Lill Anjum), Metaphysics: a Very Short Introduction (Oxford, 2012) and Causation: a Very Short Introduction (Oxford, 2013 with Rani Lill Anjum). I was editor of George Molnar's posthumous Powers: a Study in Metaphysics (Oxford, 2003) and Metaphysics and Science (Oxford, 2013 with Matthew Tugby).
  • Feminist Sport Lab: https://www.feministsportlab.com

  • Causation: A Very Short Introduction by Stephen Mumford & Rani Lill Anjum: https://academic.oup.com/book/616

  • Faye Norby, Iditarod champion & epidemiologist: https://www.kfyrtv.com/2024/03/28/faye-norby-finishes-iditarod-trail-womens-foot-champion/?outputType=amp 

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Sheree Bekker & Stephen Mumford are Co-directors of the Feminist Sport Lab and have a book coming soon: "Open Play: the case for feminist sport", coming Spring 2025. Reaktion Books (UK), University of Chicago Press (US).

Sheree Bekker: Associate Professor, University of Bath, Department for Health,

Stephen Mumford, Professor of Metaphysics, Durham University  A

  • Author of Dispositions (Oxford, 1998), Russell on Metaphysics (Routledge, 2003), Laws in Nature (Routledge, 2004), David Armstrong (Acumen, 2007), Watching Sport: Aesthetics, Ethics and Emotion (Routledge, 2011), Getting Causes from Powers (Oxford, 2011 with Rani Lill Anjum), Metaphysics: a Very Short Introduction (Oxford, 2012) and Causation: a Very Short Introduction (Oxford, 2013 with Rani Lill Anjum). I was editor of George Molnar's posthumous Powers: a Study in Metaphysics (Oxford, 2003) and Metaphysics and Science (Oxford, 2013 with Matthew Tugby).
  • Feminist Sport Lab: https://www.feministsportlab.com

  • Causation: A Very Short Introduction by Stephen Mumford & Rani Lill Anjum: https://academic.oup.com/book/616

  • Faye Norby, Iditarod champion & epidemiologist: https://www.kfyrtv.com/2024/03/28/faye-norby-finishes-iditarod-trail-womens-foot-champion/?outputType=amp 

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Erick Scott is founder of cStructure, a causal science startup. Erick has expertise in medicine, public health, and computational biology.

  • info@cStructure.io

  • "A causal roadmap for generating high-quality real-world evidence" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603361/

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Erick Scott is founder of cStructure, a causal science startup. Erick has expertise in medicine, public health, and computational biology.

  • info@cStructure.io

  • "A causal roadmap for generating high-quality real-world evidence" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10603361/

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Nima Hejazi is an assistant professor in biostatistics at Harvard University. His methodological work often draws upon tools and ideas from semi- and non-parametric inference, high-dimensional and large-scale inference, targeted or debiased machine learning (e.g., targeted minimum loss estimation, method of sieves), and computational statistics.

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Nima Hejazi is an assistant professor in biostatistics at Harvard University. His methodological work often draws upon tools and ideas from semi- and non-parametric inference, high-dimensional and large-scale inference, targeted or debiased machine learning (e.g., targeted minimum loss estimation, method of sieves), and computational statistics.

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Aaditya Ramdas is an assistant professor at Carnegie Mellon University, in the Departments of Statistics and Machine Learning. His research interests include game-theoretic statistics and sequential anytime-valid inference, multiple testing and post-selection inference, and uncertainty quantification for machine learning (conformal prediction, calibration). His applied areas of interest include neuroscience, genetics and auditing (real-estate, finance, elections). Aaditya received the IMS Peter Gavin Hall Early Career Prize, the COPSS Emerging Leader Award, the Bernoulli New Researcher Award, the NSF CAREER Award, the Sloan fellowship in Mathematics, and faculty research awards from Adobe and Google. He also spends 20% of his time at Amazon working on causality and sequential experimentation.

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Aaditya Ramdas is an assistant professor at Carnegie Mellon University, in the Departments of Statistics and Machine Learning. His research interests include game-theoretic statistics and sequential anytime-valid inference, multiple testing and post-selection inference, and uncertainty quantification for machine learning (conformal prediction, calibration). His applied areas of interest include neuroscience, genetics and auditing (real-estate, finance, elections). Aaditya received the IMS Peter Gavin Hall Early Career Prize, the COPSS Emerging Leader Award, the Bernoulli New Researcher Award, the NSF CAREER Award, the Sloan fellowship in Mathematics, and faculty research awards from Adobe and Google. He also spends 20% of his time at Amazon working on causality and sequential experimentation.

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Ingrid is a doctoral student in Epidemiology at the Dalla Lana School of Public Health at the University of Toronto. 

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Ingrid is a doctoral student in Epidemiology at the Dalla Lana School of Public Health at the University of Toronto. 

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Nick Huntington-Klein is an Assistant Professor, Department of Economics, Albers School of Business and Economics, Seattle University. His research focus is econometrics, causal inference, and higher education policy. He's also the author of an introductory causal inference textbook called The Effect and the creator of a number of Stata packages for implementing causal effect estimation procedures.

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🎶 Our intro/outro music is courtesy of Joseph McDade
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Nick Huntington-Klein is an Assistant Professor, Department of Economics, Albers School of Business and Economics, Seattle University. His research focus is econometrics, causal inference, and higher education policy. He's also the author of an introductory causal inference textbook called The Effect and the creator of a number of Stata packages for implementing causal effect estimation procedures.

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

 

 

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Published 2024-03-20

Immortal Time Bias | Season 5 Episode 3

34 min
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Lucy and Ellie chat about immortal time bias, discussing a new paper Ellie co-authored on clone-censor-weights. 

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Lucy and Ellie chat about immortal time bias, discussing a new paper Ellie co-authored on clone-censor-weights. 

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Mark van der Laan is a professor of statistics at the University of California, Berkeley. His research focuses on developing statistical methods to estimate causal and non-causal parameters of interest, based on potentially complex and high dimensional data from randomized clinical trials or observational longitudinal studies, or from cross-sectional studies. 

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Mark van der Laan is a professor of statistics at the University of California, Berkeley. His research focuses on developing statistical methods to estimate causal and non-causal parameters of interest, based on potentially complex and high dimensional data from randomized clinical trials or observational longitudinal studies, or from cross-sectional studies. 

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Ellie and Lucy kick off the season and introduce our new executive buzzer, Melita! Melita is a masters student in statistics at Wake Forest University and will be helping out with the podcast (and keeping Lucy and Ellie from using too much jargon!)

Pros & Cons of RCT paper: 

  • Fernainy, P., Cohen, A.A., Murray, E. et al. Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: a panel discussion. BMC Proc 18 (Suppl 2), 1 (2024). https://doi.org/10.1186/s12919-023-00285-8

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Ellie and Lucy kick off the season and introduce our new executive buzzer, Melita! Melita is a masters student in statistics at Wake Forest University and will be helping out with the podcast (and keeping Lucy and Ellie from using too much jargon!)

Pros & Cons of RCT paper: 

  • Fernainy, P., Cohen, A.A., Murray, E. et al. Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: a panel discussion. BMC Proc 18 (Suppl 2), 1 (2024). https://doi.org/10.1186/s12919-023-00285-8

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Cameron Bopp

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Published 2023-10-02

Remembering Ralph B. D'Agostino, Sr.

49 min
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We are re-releasing an episode from 2021 in remembrance of Ralph D'Agostino, Sr

Ellie Murray and Lucy D'Agostino McGowan chat with Ralph D'Agostino Sr. and Ralph D'Agostino Jr. about their careers in statistics, looking back at how things have developed and forward at where they see the world of statistics and epidemiology going. 

Ralph D'Agostino Sr. was a professor of Mathematics/Statistics, Biostatistics, and Epidemiology at Boston University. He was the lead biostatistician for the Framingham Heart Study, a biostatistical consultant to The New England Journal of Medicine, an editor of Statistics in Medicine and lead editor of their Tutorials, and a member and consultant on FDA committees. His major fields of research were clinical trials, prognostic models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research. 

Ralph D'Agostino Jr. is a professor in the Department of Biostatistics and Data Science at Wake Forest University where he is the Director of the Biostatistics Core of the Comprehensive Cancer Center. Methodologically his research includes developing statistical techniques for evaluating data from observational settings, handling missing data in applied problems, and developing predictive functions to identify prospectively patients at elevated risk for future negative outcomes. Some of his recent work includes the development of methods using propensity score models to identify safety signals in large retrospective databases. 

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We are re-releasing an episode from 2021 in remembrance of Ralph D'Agostino, Sr

Ellie Murray and Lucy D'Agostino McGowan chat with Ralph D'Agostino Sr. and Ralph D'Agostino Jr. about their careers in statistics, looking back at how things have developed and forward at where they see the world of statistics and epidemiology going. 

Ralph D'Agostino Sr. was a professor of Mathematics/Statistics, Biostatistics, and Epidemiology at Boston University. He was the lead biostatistician for the Framingham Heart Study, a biostatistical consultant to The New England Journal of Medicine, an editor of Statistics in Medicine and lead editor of their Tutorials, and a member and consultant on FDA committees. His major fields of research were clinical trials, prognostic models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research. 

Ralph D'Agostino Jr. is a professor in the Department of Biostatistics and Data Science at Wake Forest University where he is the Director of the Biostatistics Core of the Comprehensive Cancer Center. Methodologically his research includes developing statistical techniques for evaluating data from observational settings, handling missing data in applied problems, and developing predictive functions to identify prospectively patients at elevated risk for future negative outcomes. Some of his recent work includes the development of methods using propensity score models to identify safety signals in large retrospective databases. 

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Ellie and Lucy chat with Dr. Cat Hicks, VP of Research Insights and Director of Developer Success Lab at Pluralsight Flow, about evidence science. 

 

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Ellie and Lucy chat with Dr. Cat Hicks, VP of Research Insights and Director of Developer Success Lab at Pluralsight Flow, about evidence science. 

 

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about a "Causal Quartet" and spend some extra time on M-Bias!


 

Lucy, Travis, & Malcom's Causal Quartet Paper

Lucy's quartets R package

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about a "Causal Quartet" and spend some extra time on M-Bias!


 

Lucy, Travis, & Malcom's Causal Quartet Paper

Lucy's quartets R package

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about ENAR 2023 and Targeted Learning!

Targeted Learning in R Handbook

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🎶 Our intro/outro music is courtesy of Joseph McDade
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Lucy D'Agostino McGowan and Ellie Murray chat about ENAR 2023 and Targeted Learning!

Targeted Learning in R Handbook

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat with #EpiCookieChallenge winner, Viktoria Gastens!

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🎶 Our intro/outro music is courtesy of Joseph McDade
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Lucy D'Agostino McGowan and Ellie Murray chat with #EpiCookieChallenge winner, Viktoria Gastens!

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about confounding!

✍️ Lucy's new paper: Sensitivity Analyses for Unmeasured Confounders

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about confounding!

✍️ Lucy's new paper: Sensitivity Analyses for Unmeasured Confounders

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about randomized controlled trials, thinking about efficacy vs effectiveness and saftey vs safetiness.

✍️ Frank Harrell's blog post "Randomized Clinical Trials Do Not Mimic Clinical Practice, Thank Goodness"

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🎶 Our intro/outro music is courtesy of Joseph McDade
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Lucy D'Agostino McGowan and Ellie Murray chat about randomized controlled trials, thinking about efficacy vs effectiveness and saftey vs safetiness.

✍️ Frank Harrell's blog post "Randomized Clinical Trials Do Not Mimic Clinical Practice, Thank Goodness"

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat with Maria Glymour, Professor of Epidemiology & Biostatstics at UCSF and incoming chair of the Department of Epidemiology at Boston University. Maria successfully convinces Ellie and Lucy that instrumental variables can be very useful in epidemiology. 

Follow up:

✍️ Andrew Heiss's blog post on marginal and conditional effects for GLMMs

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat with Maria Glymour, Professor of Epidemiology & Biostatstics at UCSF and incoming chair of the Department of Epidemiology at Boston University. Maria successfully convinces Ellie and Lucy that instrumental variables can be very useful in epidemiology. 

Follow up:

✍️ Andrew Heiss's blog post on marginal and conditional effects for GLMMs

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about critiquing methods research, average treatment effects, and positivity violations!

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Lucy D'Agostino McGowan and Ellie Murray chat about critiquing methods research, average treatment effects, and positivity violations!

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🎶 Our intro/outro music is courtesy of Joseph McDade

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Lucy D'Agostino McGowan and Ellie Murray chat with Travis Gerke, Director of Data Science at The Prostate Cancer Clinical Trials Consortium (PCCTC). This episode has lots of hot takes and lots of love for logistic regression!

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat with Travis Gerke, Director of Data Science at The Prostate Cancer Clinical Trials Consortium (PCCTC). This episode has lots of hot takes and lots of love for logistic regression!

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about counterfactuals!

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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Lucy D'Agostino McGowan and Ellie Murray chat about counterfactuals!

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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In this episode Ellie Murray and Lucy D'Agostino McGowan chat with Enrique Schisterman, Perelman Professor and Chair of the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania, about the future of epidemiology.

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🎶 Our intro/outro music is courtesy of Joseph McDade

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In this episode Ellie Murray and Lucy D'Agostino McGowan chat with Enrique Schisterman, Perelman Professor and Chair of the Department of Biostatistics, Epidemiology, and Informatics at the University of Pennsylvania, about the future of epidemiology.

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🎶 Our intro/outro music is courtesy of Joseph McDade

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In this episode we play the audio from a recent panel discussion co-sponsored by UNC TraCS, Duke University and Wake Forest U CTSA Biostatistics, Epidemiology and Research Design (BERD) Cores. The panelists were Charles Poole (Associate Professor of Epidemiology, UNC) Lucy D'Agostino McGowan, and Charles Scales (Associate Professor of Surgery, Duke University) and it was facilitated by Marcella Boynton (Assistant Professor, General Internal Medicine, UNC/NC TraCS).

🎥 The video of the panel can be found here

🎞 Lucy's slides

📃 The ASA Statement on p-values

📃 The American Statistician issue on p-values following the SSI conference

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🎶 Our intro/outro music is courtesy of Joseph McDade

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In this episode we play the audio from a recent panel discussion co-sponsored by UNC TraCS, Duke University and Wake Forest U CTSA Biostatistics, Epidemiology and Research Design (BERD) Cores. The panelists were Charles Poole (Associate Professor of Epidemiology, UNC) Lucy D'Agostino McGowan, and Charles Scales (Associate Professor of Surgery, Duke University) and it was facilitated by Marcella Boynton (Assistant Professor, General Internal Medicine, UNC/NC TraCS).

🎥 The video of the panel can be found here

🎞 Lucy's slides

📃 The ASA Statement on p-values

📃 The American Statistician issue on p-values following the SSI conference

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Sander Greenland, Emeritus Professor of Epidemiology and Statistics at UCLA.

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Sander Greenland, Emeritus Professor of Epidemiology and Statistics at UCLA.

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🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Toyya Pujol, Operations Researcher at RAND Corporation.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Toyya Pujol, Operations Researcher at RAND Corporation.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Maggie Makar, Presidential postdoctoral fellow and assistant professor in Computer Science and Engineering at the University of Michigan.

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Slide link: https://bit.ly/3DnQai5

🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Maggie Makar, Presidential postdoctoral fellow and assistant professor in Computer Science and Engineering at the University of Michigan.

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Slide link: https://bit.ly/3DnQai5

🎶 Our intro/outro music is courtesy of Joseph McDade
Edited by Quinn Rose: aspiringrobot.com

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Judea Pearl, Chancellor professor of computer science and statistics at the University of California, Los Angeles.

📄 Judea's recent papers

📖 Book of Why

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Slide link: https://bit.ly/3DnQai5

🎶 Our intro/outro music is courtesy of Joseph McDade

 

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Judea Pearl, Chancellor professor of computer science and statistics at the University of California, Los Angeles.

📄 Judea's recent papers

📖 Book of Why

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Slide link: https://bit.ly/3DnQai5

🎶 Our intro/outro music is courtesy of Joseph McDade

 

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with #EpiCookieChallenge winner, Chris Schaich about the epidemiologist John Snow. Dr. Schaich is an assistant professor at Wake Forest School of Medicine in the Hypertension and Vascular Research Center.

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Slide link: https://bit.ly/3DnQai5

🎶 Our intro/outro music is courtesy of Joseph McDade

 

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with #EpiCookieChallenge winner, Chris Schaich about the epidemiologist John Snow. Dr. Schaich is an assistant professor at Wake Forest School of Medicine in the Hypertension and Vascular Research Center.

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Slide link: https://bit.ly/3DnQai5

🎶 Our intro/outro music is courtesy of Joseph McDade

 

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat about their Spotify Wrapped for Casual Inference, and Ellie Murray talks about causal inference for complex data with the University of Minnesota's epidemiology department.

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Slide link: https://bit.ly/3DnQai5

Transcript (auto-generated): https://bit.ly/3y4OskQ

🎶 Our intro/outro music is courtesy of Joseph McDade.

 

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat about their Spotify Wrapped for Casual Inference, and Ellie Murray talks about causal inference for complex data with the University of Minnesota's epidemiology department.

Follow along on Twitter:

Slide link: https://bit.ly/3DnQai5

Transcript (auto-generated): https://bit.ly/3y4OskQ

🎶 Our intro/outro music is courtesy of Joseph McDade.

 

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat about the history of causal inference, tracing the origins across disciplines from statistics to economics, epidemiology, and computer science, discussing contributions from Rubin, Robins, Pearl, and more!

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat about the history of causal inference, tracing the origins across disciplines from statistics to economics, epidemiology, and computer science, discussing contributions from Rubin, Robins, Pearl, and more!

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Hilary Parker about design thinking for data analysis, the Dunning-Kruger effect, and the potential data behind baby Yoda.

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Hilary Parker about design thinking for data analysis, the Dunning-Kruger effect, and the potential data behind baby Yoda.

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Noah Haber about metascience, causal language in the literature, and more!

🥇 Causal Inference Nobel Prize Press Release

📝 Causal and Associational Linking Language From Observational Research and Health Evaluation Literature in Practice: A systematic language evaluation

📝 What Should Researchers Expect When They Replicate Studies? A Statistical View of Replicability in Psychological Science

📝 Design principles of data analysis

📝 Causal language and strength of inference in academic and media articles shared in social media (CLAIMS): A systematic review

🔗 Reading past headlines [part 1]

🔗 Reading past headlines [part 2]

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Noah Haber about metascience, causal language in the literature, and more!

🥇 Causal Inference Nobel Prize Press Release

📝 Causal and Associational Linking Language From Observational Research and Health Evaluation Literature in Practice: A systematic language evaluation

📝 What Should Researchers Expect When They Replicate Studies? A Statistical View of Replicability in Psychological Science

📝 Design principles of data analysis

📝 Causal language and strength of inference in academic and media articles shared in social media (CLAIMS): A systematic review

🔗 Reading past headlines [part 1]

🔗 Reading past headlines [part 2]

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Len Testa, president of TouringPlans, about solving optimization problems in travel and healthcare.

📦 Lucy's R package with touringplans data

Len's slide on model choices:

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Len Testa, president of TouringPlans, about solving optimization problems in travel and healthcare.

📦 Lucy's R package with touringplans data

Len's slide on model choices:

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Ashley Buchanan about causal inference with a focus on networks. Dr. Buchanan is an assistant professor of Biostatistics in the Department of Pharmacy Practice at the University of Rhode Island.

🔗 Dr. Buchanan's website

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Lucy D'Agostino McGowan and Ellie Murray chat with Ashley Buchanan about causal inference with a focus on networks. Dr. Buchanan is an assistant professor of Biostatistics in the Department of Pharmacy Practice at the University of Rhode Island.

🔗 Dr. Buchanan's website

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🎶 Our intro/outro music is courtesy of Joseph McDade.

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In this episode Ellie Murray and Lucy D'Agostino McGowan do a series recap and then discuss sensitivity, specificity, and appropriate messaging in the context of coronavirus rapid tests.

📝 Evaluation of the Abbott BinaxNOW rapid antigen test for SARS-CoV-2 infection in children: Implications for screening in a school setting

📝 NY Times article: One in 5,000

🐦 Kareem Carr's tweet about omitted variable bias in randomized controlled trials

📝 Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated?

🦠 A calculator that lets you estimate COVID risk [microcovid]

In the (Local) News

📰 Will Podcasting and Social Media Replace Journals and Traditional Science Communication? No, but...

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🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

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In this episode Ellie Murray and Lucy D'Agostino McGowan do a series recap and then discuss sensitivity, specificity, and appropriate messaging in the context of coronavirus rapid tests.

📝 Evaluation of the Abbott BinaxNOW rapid antigen test for SARS-CoV-2 infection in children: Implications for screening in a school setting

📝 NY Times article: One in 5,000

🐦 Kareem Carr's tweet about omitted variable bias in randomized controlled trials

📝 Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated?

🦠 A calculator that lets you estimate COVID risk [microcovid]

In the (Local) News

📰 Will Podcasting and Social Media Replace Journals and Traditional Science Communication? No, but...

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

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In this 23rd episode of Casual Inference Ellie Murray and Lucy D'Agostino McGowan chat about fixed vs random effect, complete a statistics challenge, and talk about DAGs.

🐦 Tweet from @jtc475 about fixed vs random effects terminology

🎲 This is Statistics March Randomness Challenge

📝 Lucy, Kyra, and Ellie's paper "Quantifying Uncertainty in Infectious Disease Mechanistic Models"

PeDAGogy

Here are the two Bridgerton DAGs we discussed.

1. Tweet submitted by @IGMoore: 

2. Tweet submitted by @AlenaSorensen

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

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In this 23rd episode of Casual Inference Ellie Murray and Lucy D'Agostino McGowan chat about fixed vs random effect, complete a statistics challenge, and talk about DAGs.

🐦 Tweet from @jtc475 about fixed vs random effects terminology

🎲 This is Statistics March Randomness Challenge

📝 Lucy, Kyra, and Ellie's paper "Quantifying Uncertainty in Infectious Disease Mechanistic Models"

PeDAGogy

Here are the two Bridgerton DAGs we discussed.

1. Tweet submitted by @IGMoore: 

2. Tweet submitted by @AlenaSorensen

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

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In this episode Ellie Murray and Lucy D'Agostino McGowan chat with Julia Raifman about health policy, a recent study on unemployment insurance and food insecurity, and anti racism in academia. Dr. Raifman is an assistant professor of Health Law, Policy, and Management at Boston University. Her research focuses on how health and social policies drive population health and health disparities.

📝 Geoffrey Rose's paper Sick Individuals and Sick Populations

📝Julia's recent paper - Association Between Receipt of Unemployment Insurance and Food Insecurity Among People Who Lost Employment During the COVID-19 Pandemic in the United States

PeDAGogy

Come up with a Bridgerton DAG and share it with us on Twitter! Here is one for inspiration.  

Me: "Hi please fund me to do innovative research"

Also me: "Sure I'll lead a DAG discussion on the @PWGTennant et al. @IJEeditorial paper... I'd like to focus on how offensively hot the guy from Bridgerton is."@mrc_ieu and @BristolTARG PhD student Mark Gibson made my day! pic.twitter.com/CFOoYhMGjt

— Gareth Griffith (@Garethjgriffith) February 1, 2021

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

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In this episode Ellie Murray and Lucy D'Agostino McGowan chat with Julia Raifman about health policy, a recent study on unemployment insurance and food insecurity, and anti racism in academia. Dr. Raifman is an assistant professor of Health Law, Policy, and Management at Boston University. Her research focuses on how health and social policies drive population health and health disparities.

📝 Geoffrey Rose's paper Sick Individuals and Sick Populations

📝Julia's recent paper - Association Between Receipt of Unemployment Insurance and Food Insecurity Among People Who Lost Employment During the COVID-19 Pandemic in the United States

PeDAGogy

Come up with a Bridgerton DAG and share it with us on Twitter! Here is one for inspiration.  

Me: "Hi please fund me to do innovative research"

Also me: "Sure I'll lead a DAG discussion on the @PWGTennant et al. @IJEeditorial paper... I'd like to focus on how offensively hot the guy from Bridgerton is."@mrc_ieu and @BristolTARG PhD student Mark Gibson made my day! pic.twitter.com/CFOoYhMGjt

— Gareth Griffith (@Garethjgriffith) February 1, 2021

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

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In this episode Ellie Murray and Lucy D'Agostino McGowan chat with Ralph D'Agostino Sr. and Ralph D'Agostino Jr. about their careers in statistics, looking back at how things have developed and forward at where they see the world of statistics and epidemiology going. We're excited to kick off the 100th year of the American Journal of Epidemiology with this episode.

Ralph D'Agostino Sr. is a professor of Mathematics/Statistics, Biostatistics, and Epidemiology at Boston University. He has been the lead biostatistician for the Framingham Heart Study, a biostatistical consultant to The New England Journal of Medicine, an editor of Statistics in Medicine and lead editor of their Tutorials, and a member and consultant on FDA committees. His major fields of research are clinical trials, prognostic models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research. 

Ralph D'Agostino Jr. is a professor in the Department of Biostatistics and Data Science at Wake Forest University where he is the Director of the Biostatistics Core of the Comprehensive Cancer Center. Methodologically his research includes developing statistical techniques for evaluating data from observational settings, handling missing data in applied problems, and developing predictive functions to identify prospectively patients at elevated risk for future negative outcomes. Some of his recent work includes the development of methods using propensity score models to identify safety signals in large retrospective databases. 

It also turns out they are Lucy's father and grandfather, so we have 3 generations of statisticians on the pod!

We also have Amit Sasson on to discuss the winning cookie from the #EpiCookieChallenge as well as her work in causal inference!

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

 

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In this episode Ellie Murray and Lucy D'Agostino McGowan chat with Ralph D'Agostino Sr. and Ralph D'Agostino Jr. about their careers in statistics, looking back at how things have developed and forward at where they see the world of statistics and epidemiology going. We're excited to kick off the 100th year of the American Journal of Epidemiology with this episode.

Ralph D'Agostino Sr. is a professor of Mathematics/Statistics, Biostatistics, and Epidemiology at Boston University. He has been the lead biostatistician for the Framingham Heart Study, a biostatistical consultant to The New England Journal of Medicine, an editor of Statistics in Medicine and lead editor of their Tutorials, and a member and consultant on FDA committees. His major fields of research are clinical trials, prognostic models, longitudinal analysis, multivariate analysis, robustness, and outcomes/effectiveness research. 

Ralph D'Agostino Jr. is a professor in the Department of Biostatistics and Data Science at Wake Forest University where he is the Director of the Biostatistics Core of the Comprehensive Cancer Center. Methodologically his research includes developing statistical techniques for evaluating data from observational settings, handling missing data in applied problems, and developing predictive functions to identify prospectively patients at elevated risk for future negative outcomes. Some of his recent work includes the development of methods using propensity score models to identify safety signals in large retrospective databases. 

It also turns out they are Lucy's father and grandfather, so we have 3 generations of statisticians on the pod!

We also have Amit Sasson on to discuss the winning cookie from the #EpiCookieChallenge as well as her work in causal inference!

Follow along on Twitter:

🎶 Our intro/outro music is courtesy of Joseph McDade.

👩‍🎨 Our artwork is by Allison Horst.

 

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