TWiV 714: The shape of spike with Jason McLellan
Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
Guest: Jason McLellan
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Links for this episode- Prefusion spike structure (Science)
- Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer
- Novavax COVID-19 vaccine phase 3 results (Novavax)
- J&J COVID-19 vaccine phase 3 results (J&J)
- B.1.1.7 has been in the US since November 2019 (virological.org)
- NERVTAG report on B.1.1.7 virulence (pdf)
- Timestamps by Jolene. Thanks!
Dickson – Pandemic Pivot and Tuba Skinny Alan – Technological challenges in vaccine rollout Rich – I was lucky to find this vaccine anywhere Vincent – Lady Gaga's MIXED METER Star Spangled Banner?!
Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv
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