TWiV 1262: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin with Vincent Racaniello are dismayed by the government shutdown, the firings at the CDC including EIS agents, H5N1 isolation from backyard birds and its stability in raw milk and cheese, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the quarantining of college students in the US due to measles, Japan's declaration of a national influenza outbreak, effectiveness of the influenza and COVID vaccines, where to find PEMGARDA, how to access and pay for Paxlovid, can you be retreated with Paxlovid, long COVID treatment center, results from PLATCOV studies- still no antiviral activity attributed to ivermectin, where to go for answers to your long COVID questions, long COVID in pediatrics, patient reported outcomes from the STOP-PASC clinical trial, contacting your federal government representative to stop the assault on science and biomedical research and the listener reminder that measles vaccine in those with interferonopathy may result in severe adverse affects.

Become a patron of TWiV!

• Trump Administration Lays Off Dozens of C.D.C. Officials (NY Times)
• CDC walks back hundreds of firings as US shutdown persists (Yahoo News/ Reuters)
• CDC battered by government shutdown firings, while some are rescinded (STAT 10)
• Confirmations of Highly Pathogenic Avian Influenza in Commercial and Backyard Flocks (USDA: Animal and Plant Health Inspection Service)
• Flurry of H5N1 activity noted in commercial poultry, wild birds(CIDRAP)
• H5N1 influenza virus stability and transmission risk in raw milk and cheese(Nature Medicine)
• Hundreds of U.S. students quarantined amid measles outbreaks (NBC News)
• Wastewater for measles (WasterWater Scan)
• Measles cases and outbreaks (CDC Rubeola)
• Tracking Measles Cases in the U.S. (Johns Hopkins)
• Measles vaccine recommendations from NYP (jpg)
• Weekly measles and rubella monitoring (Government of Canada)
• Measles (WHO)
• Get the FACTS about measles (NY State Department of Health)
• Measles (CDC Measles (Rubeola))
• Measles vaccine (CDC Measles (Rubeola))
• Presumptive evidence of measles immunity (CDC)
• Contraindications and precautions to measles vaccination (CDC)
• Measles (CDC Measles (Rubeola))
• Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
• Measles Vaccination: Know the Facts(ISDA: Infectious Diseases Society of America)
• Deaths following vaccination: what does the evidence show (Vaccine)
• Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Respiratory virus activity levels (CDC Respiratory Illnesses)
• Weekly surveillance report: clift notes (CDC FluView)
• Japan sees early flu activity, with school closures(CIDRAP)
• Japan Declares Nationwide Flu Outbreak Following Early Surge in Cases (insightscare)
• ACIP Recommendations Summary (CDC: Influenza)
• American Academy of Pediatrics
• Flu and Children (CDC: Influenza (flu))
• Effectiveness of influenza vaccination to prevent severe disease (CMI: Clinical Microbiology and Infection)
• Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season(FDA)
• RSV: Waste water scan for 11 pathogens (WastewaterSCan)
• US respiratory virus activity (CDC Respiratory Illnesses)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
• Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
• Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases)
• Efficacy and safety of respiratory syncytial virus vaccines (Cochrane Library)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 deaths (CDC)
• Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV)
• Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents (The Pediatric Infectious Disease Journal)
• Trump gets Covid vaccine and flu shot during second checkup of the year (NBC News)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Infusion center (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Drug interaction checker (University of Liverpool)
• Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro)
• Understanding Coverage Options (PAXCESS)
• Pharmacometrics of high-dose ivermectin in early COVID-19 from an open label, randomized, controlled adaptive platform trial (PLATCOV)(eLife)
• Antiviral efficacy of oral ensitrelvir versus oral ritonavir-boosted nirmatrelvir in COVID-19 (PLATCOV) (LANCET: Infectious Diseases)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• Managing healthcare staffing shortages (CDC)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• The answers: Long COVID
• Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection (JAMA Internal Medicine)
• Longitudinal patient-reported outcome trajectories in Long COVID: Findings from the STOP-PASC Clinical Trial (OFID)
• Reaching out to US house representative
• Severe Adverse Reaction to Measles Vaccine Due to Homozygous Mutation in the IFNAR2 Gene: A Case Report and Literature Review (Journal of Clinical Immunology)
• Letters read on TWiV 1262
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Content in this podcast should not be construed as medical advice.