Immune 64: A tangled web of wires

Cindy, Steph, Brianne, and Vincent do a rapid review 11 immunology papers, including a wiring diagram for the immune system, group A streptococcus vaccines, systems immunology prediction of vaccines, class switch towards IgG4 after SARS-CoV-2 mRNA vaccination, very bad B cells, monoclonal antibody to two streptococcal M protein epitopes, transcriptional atlas of response to 13 vaccines, impact of SARS-CoV-2 exposure history on T cell and IgG response, neutrophilic inflammation predisposes to RSV infection, commensals avoiding recognition, and continuous germinal center invasion contributes to diversity of immune response.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

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• Tangled web of wires (Nature)
• Path to group A Streptococcus vaccines (Clin Inf Dis)
• Immune end-types predictive of vaccine responses (Nat Immunol)
• IgG4 switch after SARS-CoV-2 mRNA vaccination (Sci Immunol)
• Very bad B cells (Immunity)
• Two epitope Streptococcus monoclonal (EMBO Mol Med)
• Predictor of vaccine-induced antibody responses (Nat Immunol)
• Impact of SARS-CoV-2 exposure history on antibody an T cell response (Cell Rep Med)
• Neutrophilic inflammation and RSV infection (Science)
• Commensals avoiding recognition (Sci Immunol)
• Continuous germinal center invasion and immune response diversity (Cell)
• Time stamps by Jolene. Thanks!

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