Immune

Nicholas Jackson, AKA Nick the Immunologist, talks about being a graduate student, social media creator, and his research on cytokine tools to investigate regulatory T cells.

Host: Cindy Leifer

Guest: Nicholas Jackson (Nick the Immunologist)

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• MicrobeTV Discord Server
• Richard DiPaolo lab
• IL-2, TGFb and Tregs preprint
• Nick the Immunologist on TikTok
• Nick the Immunologist on Instagram
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Luke O'Neill recounts his role in discovering key components of the TLR signaling pathway, explains how pursuing unexpected research questions keeps him motivated, and reflects on his experiences as an entrepreneur founding biotech companies.

Host: Cindy Leifer

Guest: Luke O'Neill

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• MicrobeTV Discord Server
• O'Neill lab
• Identification of MAL in the TLR signaling pathway (Nature, 2001)
• GDF 15, immunometabolism and anti-inflammatories (An Rev Pharmacol Tox, 2026)
• Itaconate and regulation of inflammation (Nat Metab, 2024)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

George Stark from the Cleveland Clinic reflects on his early training in biochemistry and how several sabbatical leaves sparked pivotal changes in his research trajectory, eventually drawing him to interferon signaling where he helped establish the core principles of the JAK–STAT pathway and uncovered interesting roles for interferon signaling in cancer.

Host: Cindy Leifer

Guest: George Stark

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• MicrobeTV Discord Server
• Stark lab
• Development of the Northern blotting technique (PNAS, 1977)
• Development of Western blotting for proteins (PNAS, 1979)
• Discovery of Tyk2 as a critical kinase in interferon response (Cell, 1992)
• Topical PALA treatment for non-melanoma skin cancer (Exp Dermatol, 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

The Immune team talks all about cytokines, from what they are to immunotherapies against them to treat diseases.

Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Non-specific virus neutralization by IgM and complement (mBio 2026)
• Natural antibodies against viruses (Virology blog, 2009)
• Biologics against inflammatory cytokines (Int J Cell Bio, 2016)
• Biologics against allergic cytokines (JACI, 2022)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Irah King from McGill University talks about his passion to understand how our immune system detects and responds to helminthic worm infections, how the worms can reprogram those responses, and how these pathways might be exploited to develop new treatments for inflammatory diseases.

Host: Cindy Leifer

Guest: Irah King

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• MicrobeTV Discord Server
• King lab at McGill
• Stromal cells and disease tolerance against intestinal infection (Cell, 2025)
• Helminth-Microbiome Interactions in Early Life (Cell, Host, & Microbe, 2024)
• BCL6, CD4T cells and parasitic infection (Mucoslal Immunol, 2023)
• Helminths manipulate the intestinal epithelium (Trends Parasit, 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

The Immune team discusses a paper describing the negative effects of old B cells on T cells and longevity and a snippet on an interesting vaccine approach to promote competition between gut commensals.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Vaccine enhanced competition of gut bacteria (Science 2025)
• B cells drive immunosenescence and aging (Sci Immunol 2026)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

A former anti-vax mom talks about going down the rabbit hole, her mindset shift, the importance of doctors who are willing to talk with patients about vaccines, and why she is now a vaccine advocate.

Host: Cindy Leifer

Guest: Ellen Mary Woods

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• MicrobeTV Discord Server
• A shot at life foundation
• Voices for Vaccines information and advocacy
• What the iPhone bendgate can teach us about vaccine hesitancy
• Tips for conversations with vaccine hesitant people
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Gabrielle Rizzuto from Memorial Sloan Kettering Cancer Center discusses her work on the curious immunology of pregnancy and how a woman tolerates a genetically different baby but quickly rejects a mismatched organ donation.

Host: Cindy Leifer

Guest: Gabrielle Rizzuto

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• MicrobeTV Discord Server
• Rizzuto lab at MSKCC
• Tolerance at the fetal-maternal interface (Nature, 2022)
• The paradox of fetal-maternal tolerance (J Exp Med, 2022)
• Spatially resolved timeline of fetal-maternal interface (Nature, 2023)
• Time stamps by Jolene Ramsey. Thanks!

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Information on this podcast should not be construed as medical advice.

Immune discusses how tattoo ink accumulates in lymph nodes, promotes inflammation and influences response to two different vaccines.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

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• MicrobeTV Discord Server
• IL-9, CAR T cells and anti-tumor CD8 cells
• Tattoo ink, inflammation and vaccines
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Anna Beaudin from University of Utah talks about the key thread of her career, development, and how that influences her research on the events happening during critical prenatal windows shapes everything from the developing immune system to hearing loss.

Host: Cindy Leifer

Guest: Anna Beaudin

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• MicrobeTV Discord Server
• Beaudin lab at University of Utah
• PhD work on metabolism and development
• Postdoc work on hematopoietic stem cells
• Maternal inflammation and hematopoietic stem cell development
• Prenatal inflammation effect on postnatal immunity
• Early life inflammation and hearing loss
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Host: Cindy Leifer

Guest: Leslie Berg

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• MicrobeTV Discord Server
• Berg lab at University of Colorado Anschutz
• TCR thresholds and ITK (PNAS)
• Review on TCR signaling (Nat Immunol)
• Generation of TCR transgenic mice (Mol Cell Bio)
• T cell negative selection in TCR transgenic mice (Nature)
• Thymic exit of mature T cells in TCR transgenic mice (Cell)
• AAI past president Berg information
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

The whole Immune gang gathers with special guests Gretchen Diehl and Shruti Naik at The Incubator with an audience to celebrate the 100th episode.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

Guests: Gretchen Diehl and Shruti Naik

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• MicrobeTV Discord Server
• Diehl: Gut microbe-specific T cell development (Nature 2021)
• Diehl: Bacteria-induced IL-1 is gut protective (Gut Microbes 2022)
• Diehl: Microbiota, macrophages, IL10, and colitis (Gut Microbes 2022)
• Diehl: E. coli-activated circuit restrains gut inflammation (Cell Rep 2025)
• Naik: Commensals control skin inflammation (Science 2012)
• Naik: IL-17 and hypoxic stress during skin repair (Science 2022)
• Naik: Human psoriasis and spatial transcriptomics (Sci Immunol 2023)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.

Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

David Schatz talks about his discovery of Rag genes that are critical for antigen receptor development and how that discovery depended on taking high risks and using approaches that everyone thought could never work.

Host: Cindy Leifer

Guest: David Schatz

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• MicrobeTV Discord Server
• Transfer of recombinase activity in non-lymphoid cells (Cell 1988)
• Identification of the RAG-1 gene (Cell 1989)
• Evolution of a recombinase (Semin Immunol 2004)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

The Immune team discusses the groundbreaking discoveries of regulatory T cells, which was the topic of the 2025 Nobel Prize in Physiology or Medicine.

Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Sakaguchi lab paper on FoxP3 and regulatory T cells (Science 2003)
• Brunkow and Ramsdell description of scurfy mouse mutation (Nature 2001)
• Nobel Prize writeup on Treg discoveries
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Susan Schwab talks about how she got the research bug, bugs she ate, and her research on how the lipid S1P helps T cells decide- should I stay or should I go.

Host: Cindy Leifer

Guest: Susan Schwab

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• MicrobeTV Discord Server
• Schwab lab website
• Monocytes produce the lipid S1P to regulate T cell movement
• Review on S1P and immune cell migration
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Immune discusses cross-reactive antibodies to avian influenza neuraminidases and a role for gut-derived T cells in the brain to regulate eating behavior.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Antibody cross-reactivity to influenza H5N1 (Cell Host Microbe, 2025)
• Gut-derived T cells regulate behavior (Nature, 2025)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Kristian Andersen from Scripps Research Institute joins Cindy to talk about how he got interested in virus evolution, how the immune system drives viral adaptation, and what we can learn from this research to better prepare us for the next pandemic.

Guest: Kristian Andersen

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• MicrobeTV Discord Server
• Andersen Lab website
• Perspective on Immunological drivers of virus emergence
• Kristian's appearance on TWiV 774
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Cindy and Steph discuss a paper that challenges the textbook dogma that B cells must first bind to an antigen for antibody affinity maturation to occur, and a snippet on dysfunctional T cells during bacterial vaginosis.

Hosts: Cindy Leifer and Steph Langel

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• MicrobeTV Discord Server
• Somatic hypermutation in non-specific B cells (Immunity 2025)
• Dysfunctional T cells during bacterial vaginosis (J Clin Invest 2025)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Cindy sits down with Bali Pulendran at the AAI 2025 meeting where he told the story of how a childhood fascination with the cosmos grew into a career addressing fundamental questions about the human immune response, and how when an antigen enters the body it is like the big bang in how it initiates immune responses.

Host: Cindy Leifer

Guest: Bali Pulendran

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• MicrobeTV Discord Server
• Systems vaccinology determines antibody responses and durability (Nature 2025)
• World's largest immunology experiment (Sem Immunol 2024)
• Systems Vaccinology Review (Immunity 2010)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Elizabeth Marnik, also known as Science Whiz Liz, grew up unvaccinated, yet she is now an immunologist, science communicator, and advocate for vaccines–this is her story.

Guest: Elizabeth Marnick

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• MicrobeTV Discord Server
• More about Liz on her webpage
• ScienceWhizLiz on Instagram
• From the Science Classroom with Science Whiz Liz on Substack
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Immune discusses the potential future of delivering vaccines by flossing your teeth and how antibodies in human milk shape the normal immune responses in newborns.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Floss-based vaccination (Nat Biomed Engineering 2025)
• Press article on Floss-based vaccine paper (Sci News)
• Human milk IgA promotes immune development (PNAS 2025)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Cindy speaks with Aimee Pugh Bernard from University of Colorado about her career and her passion for teaching and communicating immunology to the public.

Host: Cindy Leifer

Guest: Aimee Pugh Bernard

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• MicrobeTV Discord Server
• More about Aimee on her webpage
• Funsizeimmuninja on Instagram
• Fun Size Science video partnership with Unbiased Science
• Funsizeimmuninja Substack
• Society for Leukocyte Biology
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Immune discusses how cancer cells swap mitochondria with T cells and then digs in for a discussion of an unusual checkpoint blockade that failed for cancer but could be repurposed for autoimmune inflammation.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Cancer cells steal mitochondria from neurons for metastasis (Nature 2025)
• Cancer cells donate damaged mitochondria to T cells to impair them (Nature 2025)
• PD-L1 binding to CD80 on the same dendritic cell needed for migration (Sci Adv 2025)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Cindy talks with Shane Crotty about his teenage days driving 3 ½ hours every weekend to have his first research experience in marine biology, how that eventually led to studying how vaccines work and how we can make them better, and how immunology research and publishing got a turbo-boost during the pandemic.

Hosts: Cindy Leifer

Guest: Shane Crotty

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• MicrobeTV Discord Server
• Immune 85 discusses Crotty lab paper on human upper airway immunity
• Shane Crotty on TWiV657 SARS-CoV-2 immunity
• Shane Crotty on TWiV684 Persistence of SARS-CoV memory
• Shane on TWiV802 Another epitope
• Time stamps by Jolene Ramsey. Thanks!

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Information on this podcast should not be construed as medical advice.

The Immune team goes up the nose to discuss cytotoxic T cells activating complement through secretion of granzyme K to drive inflammatory nasal polyps and how IgA-producing B cells are made in the nose.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

• MicrobeTV Discord Server
• CD8 T cells in recurrent airway inflammation (Nature 2025)
• Where IgA producing B cells arise that protect the nose (Nature 2024)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne talk with Darren Lee to discuss his career, how he got interested in immunology of the eye, and how his team visualizes immune responses of the eye in real time with the hope of better understanding autoimmune uveitis.

Hosts: Cindy Leifer and Brianne Barker

Guest: Darren Lee

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• MicrobeTV Discord Server
• The eye is an immunosuppressive environment (Adv Drug Delivery Rev 2023)
• Tregs control autoimmune uveitis (Sci Rep 2025)
• TIGIT, Tregs, and autoimmune uveitis (J Leuk Biol 2024)
• Society for Leukocyte Biology
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Vincent and Cindy discuss differences between MPox-specific T cell responses following infection and vaccination, and lymph node macrophage control of memory B cell localization and trafficking that might be important for choosing which arm to get a vaccine.

Hosts: Vincent Racaniello and Cindy Leifer

• MicrobeTV Discord Server
• Different T memory response to MPox infection or vaccination (Nat Comm 2025)
• Macrophages direct B cell recall responses after vaccination (Cell 2025)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Cindy and Brianne sit down with Justin Wilson to talk about how he got into research and his more recent studies on innate immune sensors and the interaction between the gut microbiome and inflammation related to inflammatory bowel disease and cancer.

Hosts: Cindy Leifer and Brianne Barker

Guest: Justin Wilson

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• MicrobeTV Discord Server
• Francisella tularensis undermining macrophage defenses (Infect Immunity)
• AIM2 suppressing colon cancer (Nature Med)
• NLRP12 regulates gut microbiota homeostasis (Cell Host Microbe)
• Oral bacteria and carcinogenesis connection (Microbiol Mol Bio Rev)
• Society for Leukocyte Biology
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Steph talks about identification of gut bacteria that can digest protective mucosal antibodies and Vincent covers a new paper on Zika virus that implicates fetal phagocytes in brain invasion, which may provide insight into the devastating microcephaly outcome of infection during pregnancy.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

• MicrobeTV Discord Server
• Gut bacteria induce mucosal immunodeficiency (Science)
• Contribution of fetal mononuclear phagocytes to Zika virus neuroinvasion (Cell)
• TWiV468 discusses Zika and brain slice infection model.
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Holger Heine about the discovery of immune recognition of bacterial lipopolysaccharide and innate immunity to organisms within the kingdom Archaea.

Guest: Holger Heine

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• MicrobeTV Discord Server
• TLR8 recognizes human gut-associated archaeon (Front Immunol)
• The human archaeome and its relevance for health and disease (FEBS)
• Structural insights into TLR4 recognition of synthetic LPS mimetics (Nature Comm)
• Society for Leukocyte Biology
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

Immune talks with David Peterson and Kim Klonowski from the University of Georgia about their careers, their People, parasites, and plagues podcast, placental malaria immunity, and and how interferons in the thymus affect T cell repertoire selection.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Guests: David Peterson and Kim Klonowski

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• MicrobeTV Discord Server
• People, parasites, and plagues podcast
• Placental malaria and circumsporozoite protein-specific immunity (Trends in Parasitology)
• Sterile production of interferons in the thymus affects T cell repertoire selection (Science Immunology)
• Dickson Despommier's book People Parasites and Plowshares
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Information on this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting, Immune talks with Amy Hise about her career in science, her current research using mouse models for investigating fungal immunity and navigating the challenges of being a mom in science.

Hosts: Cindy Leifer and Brianne Barker

Guest: Amy Hise

• MicrobeTV Discord Server
• Mouse model for testing drugs to treat Candida fungal infection
• Inflammasomes in Aspergillosis
• Society for Leukocyte Biology
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Content in this podcast should not be construed as medical advice.

From the 2024 Society for Leukocyte Biology meeting at Michigan State University, home of the Spartans, Immune's Cindy and Brianne talk with Liz Kovacs and Jim Lederer about their careers, dirty mice, old mice, and immunity during trauma.

Hosts: Cindy Leifer and Brianne Barker

Guests: James Lederer and Elizabeth Kovacs

• MicrobeTV Discord Server
• Jim Lederer's Neutrophil trained immunity and Trauma effects on immune cells
• Liz Kovacs's Aging and lung inflammation and Alcohol effects on burn patients
• Paper on use of "dirty mice" also known as natural immune mice
• Society for Leukocyte Biology
• Time stamps by Jolene Ramsey. Thanks!

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Information on this podcast should not be construed as medical advice.

From the The Society for Leukocyte Biology 2024 conference at Michigan State University, Cindy and Brianne sit down with Amanda Brown from Johns Hopkins School of Medicine to talk about her career and the research of her laboratory on mechanisms of neuroinflammation in disease, especially during HIV infection.

Hosts: Cindy Leifer and Brianne Barker

Guest: Amanda Brown

• Society for Leukocyte Biology
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Content in this podcast should not be construed as medical advice.

Immune discusses how non-neutralizing antibodies can still be protective…intracellularly, and a technically innovative paper that uses Lipstic to label antigen-presenting cells responsible for gut tolerance to food antigens.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Non-neutralizing antibodies protect against CCHFV (Nat Comm)
• APC-T cell interactions drive immune responses to food (Science)
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune describes the use of bespoke antibodies to characterize immune cell populations in cave nectar bats, and co-option of retrotransposons to activate hematopoietic stem cells and erythropoiesis.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Immune cells in cave nectar bats (Cell Rep)
• Cave nectar bat colony (J Am Asso Lab An Sci)
• Retrotransposons activate erythropoiesis (Science)
• TLRs and ERVs (Immunity)
• Letters read on Immune 88
• Time stamps by Jolene Ramsey. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Immune discusses basophils as regulators of of lung inflammation over space and time, and neoself-antigens as the primary target for autoreactive T cells in human lupus.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Basophils promote asthma (J Exp Med)
• Basophils regulate lung inflammation (J Exp Med)
• Neoself antigens are primary T cell targets in lupus (Cell)
• Time stamps by Jolene. Thanks!

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Immune explains how distinct olfactory mucosal macrophage populations mediate neuronal maintenance and pathogen defense, and failure to establish durable SARS-CoV-2-specific plasma cells in the bone marrow long-lived compartment after mRNA vaccination.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Nasal mucsosal macrophages, neuronal maintenance, and pathogen defense (Mucos Immunol)
• No long lived memory B cells after SARS-CoV-2 mRNA vaccination (Nat Comm)
• Time stamps by Jolene. Thanks!

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Immune explores the immunological diversity in the upper airway, including memory B and T cells and germinal center B cells, and how chronic infection with Plasmodium parasites leads to development of B cell cancers.

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

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• MicrobeTV Discord Server
• Immune memory diversity in human upper airway (Nature)
• How Plasmodium infection promotes B cell cancers (Cell)
• Time stamps by Jolene. Thanks!

Music by Tatami. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Petter Brodin joins Immune to discuss immune system adaptation in individuals assigned female sex at birth and undergoing gender affirming testosterone therapy (trans-men).

Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker

Guest: Petter Brodin

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• MicrobeTV Discord Server
• Petter Brodin on TWiV 568
• Gender-affirming testosterone treatment (Nature)
• Time stamps by Jolene. Thanks!

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From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Mark Shlomchik to talk about his career and the research of his laboratory on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis.

Hosts: Cindy Leifer and Steph Langel

Guest: Mark Shlomchik

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Heather Caslin to talk about her training and the research of her laboratory on how diet and exercise affect innate immune cells in health and disease.

Hosts: Cindy Leifer and Brianne Barker

Guest: Heather Caslin

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

Immune discusses two stories of immune cells eating other cells: microglia engulfing brain neurons to shape cortical development and behavior, and mast cells trapping neutrophils to increase their functional and metabolic fitness.

Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker

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• MicrobeTV Discord Server
• Microglia shape cortical development and behavior (Cell)
• Neutrophil trapping by mast cells (Cell)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with David Martinez to talk about his career, the research of his laboratory on viral pathogens of global health importance, and his advice to be persistent and enjoy the journey.

Hosts: Cindy Leifer and Steph Langel

Guest: David Martinez

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Robert Binder to talk about his career, the research of his laboratory on the role of heat shock proteins in cancer immunosurveillance, and the importance of inspiring students as early as possible to think about science.

Hosts: Cindy Leifer and Brianne Barker

Guest: Robert Binder

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Rafael Polidoro to talk about his career, the research of his laboratory on how the gut microbiome modulates the local and systemic immune responses during infections.

Hosts: Cindy Leifer and Steph Langel

Guest: Rafael Polidoro

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

Immune reviews the local and systemic responses after human SARS-CoV-2 challenge infection, and how bat antibodies display elevated antigen binding strength and diversity at higher temperatures that are characteristic of flight.

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• MicrobeTV Discord Server
• Responses to human SARS-CoV-2 challenge (Nature)
• Temperature-sensitivity of bat antibodies (Nat Comm)
• Time stamps by Jolene. Thanks!

Music by Steve Neal. Immune logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Steph meet up with Jane Buckner to talk about her career, and the research of her laboratory on mechanisms by which regulation of the adaptive immune response fails or is overcome in the setting of human autoimmunity.

Hosts: Cindy Leifer and Steph Langel

Guest: Jane Buckner

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Tonya Webb to talk about her career, the role of NKT cells in cancer, and her efforts to ensure diversity, equity, and inclusion in research.

Hosts: Cindy Leifer and Brianne Barker

Guest: Tonya Webb

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.

From the American Association of Immunologists 2024 conference in Chicago, Cindy and Brianne meet up with Michal Tal to talk about her career, sex differences in immune responses, and how one giant mouse uterus changed the trajectory of her research career.

Hosts: Cindy Leifer and Brianne Barker

Guest: Michal Tal

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Music by Tatami. Logo image by Blausen Medical Send your immunology questions and comments to immune@microbe.tv

Content in this podcast should not be construed as medical advice.