This Week in Virology

The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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• Journal of Microbiology & Biology Education sci comm issue
• Mark Wainberg dies
• Giant viruses with many translation system components (Science)
• Viruses in the oceanic basement (mBio)
• 2-back test
• Photo by Judy
• Letters read on TWiV 437

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Kathy - Cloud appreciation society Rich - High Rise Urban Farming Dickson - Planets orbiting a distant star Vincent - TWiEVO 18: Raiders of the lost orco

Kevin - Cherry blossoms at Brooklyn Botanical Garden

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guests: Susan Daniel, Colin Parrish, and Gary Whittaker

At Cornell University in Ithaca, New York, Vincent speaks with Susan, Colin, and Gary about the work of their laboratories on parvoviruses, influenza viruses, and coronaviruses that infect dogs, cats, horses and other mammals.

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• Daniel Laboratory
• Parrish Laboratory
• Whittaker Laboratory

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque.

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• ASM Grant Writing Course
• Screwworm letters
• Blood DNA virome of 8,240 humans (PLoS Path)
• Plaque co-infection frequencies (mBio)
• Ode to a plaque (TWiV 68)
• Counting viruses (Virus Watch)
• First animal virus plaque assay (J Exp Med)
• Letters read on TWiV 435

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Alan - Couple donates insect collection Kathy - Why is science important to you? Rich - Hook Dickson - Ten Incredible Astronomy Pictures Vincent - Why Trump's NIH Cuts Should Worry Us and The Real Threat to National Security: Deadly Disease

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The esteemed TWiVumvirate reveal the discovery of a new negative stranded RNA virus of wasps that regulates longevity and sex ratio of its parasitoid host.

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• ASM Microbe 2017
• Parasitoid wasp virus regulates sex ratio (PLoS Path)
• What is a contig?
• Image credit
• Letters read on TWiV 434

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Alan - The Wrath of Khan from Bug Chicks Kathy - Boaty McBoatface submarine launching Dickson - Fierce animal portraits Vincent - Westworld

Hannah - Plague, Inc Stig - John Oliver: Trump vs the truth

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The lovely TWiV team explore evolution of our fecal virome, and the antiviral RNA interference response in the nematode C. elegans.

Become a patron of TWiV!

• ASM Clinical Virology Symposium
• Evolution of the human fecal virome (PNAS)
• Antiviral RNAi response in C. elegans (Curr Biol)
• Orsay virus (TWiV 123)
• Broad VSV host range (J Comp Neurol)
• Image credit
• Letters read on TWiV 433

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Alan - Contact information for Senators and Representatives Kathy - How Tumor Virology Transformed Oncology Dickson - Seven new species of Peacock Spider Vincent - Proposed NIH budget cut and Expensive Oxford Comma

Kim - Pigeon Fashion Week (TWiEVO 7) Richard - aeroMorph and Understanding Molecular EvolutionJohnye - Ice Instruments and Fahrenheit and Celsius

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses.

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• Nido2017 Meeting
• ASMCUE
• Seroprevalence of Zika virus in wild monkeys and baboons (mSphere)
• Zika virus mRNA vaccines (paper one, paper two)
• Gamete fusion protein is type II viral fusogen (paper one, paper two)
• Image credit
• Letters read on TWiV 432

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Alan - Raspberry pi Kathy - The Worst F&#%ing Words Ever</a> Dickson - <a href= "https://climate.nasa.gov/images-of-change?id=597#597-landslide-in-glacier-bay-national-park-and-preserve-alaska" target="_blank">NASA images of climate change</a>Brianne - <a href= "http://rocs.hu-berlin.de/D3/herd/" target="_blank">How herd immunity works</a> Vincent - <a href= "https://www.nytimes.com/2017/03/09/world/asia/radioactive-boars-in-fukushima-thwart-residents-plans-to-return-home.html?_r=0" target="_blank">Radioactive boars in Fukushima</a><a href= "http://physicsgirl.org/" target="_blank"></a></p> Listener Pick <p>Margaret - <a href= "http://www.ravelry.com/patterns/sources/denatureanneal/patterns" target="_blank">DNA socks and gloves</a></p> <p>Intro music is by <a href="http://www.ronaldjenkees.com" target="_blank">Ronald Jenkees</a>.</p> <p>Send your virology questions and comments to twiv@microbe.tv</p>

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak.

Become a patron of TWiV!

• Nido2017 Meeting
• ASM Microbe 2017
• Mark Buller obituary
• RS virus pipeline (pdf)
• Prophage WO genes and cytoplasmic incompatibility (Nature)
• Vanderbilt Virology (TWiV 332)
• Basis for increased Ebolavirus glycoprotein activity (Cell Host Micr)
• Letters read on TWiV 431

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Rich - Germ Theory by Robert P. GaynesAlan - Student Scientist Partnerships Kathy - Symbiartic Dickson - PaleoBioDB Navigator Vincent - Kusama Infinity Room

Chaim - How to fight back against the backfire effect

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

The TWiX cabal discuss sexual transmission of Zika virus in mice, and how immune escape enables herpes simplex virus escape from latency.

Become a patron of TWiV!

• Nido2017 Meeting
• ASM Clinical Virology Symposium
• Zika virus sexual transmission in mice (Cell Rep)
• Viral RNA is not infectious virus (virology blog)
• Methyl-phospho switch (TWiV 369)
• Immune escape of herpesvirus from latency (Cell Rep)
• Restarting lytic gene expression (J Virol)
• Letters read on TWiV 430

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free with your first purchase – WITH FREE SHIPPING – by going to blueapron.com/twiv

Rich - Vipassana Momma (Dravet Syndrome) Kathy - Landlines Chrome Experiments Dickson - Origami Revolution Vincent - Hunched Over a Microscope

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guests: Katie Antony, Tom Friedrich, Emma Mohr, and David O'Connor

Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis.

Become a patron of TWiV!

• Badgers Go Viral (TWiV 260)
• Rhesus macaque model of Zika virus infection (Nat Commun)
• Heterologous Zika virus protection in macaques (PLoS NTD)
• ZEST Data Portal

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVsters explain how superspreader bacteriophages release intact DNA from infected cells, and the role of astrocytes in protecting the cerebellum from virus infection.

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• Nido2017 Meeting
• Superspreader bacteriophages (mBio)
• Astrocytes, interferon, and viral infection (JCI)
• Viral disruption of blood brain barrier (Trends Micro)
• On Warts by Lewis Thomas (pdf)
• Letters read on TWiV 428

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv

Alan - Skulls Unlimited Rich - Bernard Moss Reflection Kathy - Why vaccines don't cause autism Dickson - Honomobo Vincent - Trump vs FDA

Send your virology questions and comments to twiv@microbe.tv

Guest: Vincent Munster

At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses.

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• Rocky Mountain Laboratory
• Munster Laboratory
• Small town, big science (TWiM 140)
• Image credit

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus.

Become a patron of TWiV!

• ASM 2017 election is now open - VOTE HERE
• ASM Election questions:
  • Which positions are we voting for?
  • What is the ASM Board of Directors? Organization Chart
  • What is the Council on Microbial Sciences? Organization Chart
  • FAQs
• Scientists' march is bad idea (NY Times)
• GOF moratorium lifted (Archived White House)
• VSV gene order (PNAS)
• VSV gene order later (PNAS)
• Letters read on TWiV 427

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv

Alan - Good Omen miniseries (book) Kathy - How to cure earworms Dickson - Exoplanets orbits Vincent - Outbreak News Today

Tom - The Smartest Protester

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells.

Become a patron of TWiV!

• Register for ASV 2017
• ASM 2017 election is now open - VOTE HERE
• ASM Election questions:
  • Which positions are we voting for?
  • What is the ASM Board of Directors? Organization Chart
  • What is the Council on Microbial Sciences? Organization Chart
  • FAQs
• Scientists March on Washington
• Spontaneous generation of unique cervid strain (mSphere)
• Zika virus entry into human glial cells via Axl (Cell Rep)
• Article collections: PNAS, Cell, Nature, Virology
• Letters read on TWiV 426

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Alan - Deerland by Al Cambronne Dickson - Antarctica's Colorful Underwater World Kathy - You can't unring a bell #1 and #2 Rich - Extra letters added to life's genetic code (source) and The Doomsday Clock (wiki) Vincent - Trump Science Advisors, National Parks Won't Be Silenced

Stefan - The Vital Question by Nick Lane Kevin - Scientists March on Washington? Dennis - Fractal Tree of Life

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection.

Become a patron of TWiV!

• Register for ASV 2017
• ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens
• XKCD #242
• Thermostable poliovirus empty capsid vaccine (PLoS Path)
• Switch between viral entry and clearance (Nature)
• Glass poliovirus by Jason Roberts
• Letters read on TWiV 425

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what's on the menu this week and get your first 3 meals free – WITH FREE SHIPPING – by going to blueapron.com/twiv.

Alan - Medical lab whirligig Dickson - Antarctica's Colorful Underwater World Kathy - Prince Rupert's drops #1 and #2 Rich - Dylan's 30th - Eric Clapton --Don't Think Twice, It's All Right (The 30th Anniversary Concert Celebration) Vincent - Saving climate data and Public Good and Public Funding of Science

Suellen - For the anti-vaccine people

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Trudy Rey

Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago.

Become a patron of TWiV!

• Welcome omega tau to MicrobeTV
• Register for ASV 2017
• Oliver Smithies dies
• Assays for prions in the blood (one, two)
• Biosafety working on prions (Michigan State)
• Marine origin of retroviruses in Palaeozoic era (Nature Comm)
• Cancer Virus by Dorothy Crawford
• Adenovirus and obesity (Int J Chronic Dis)
• Image credit
• Letters read on TWiV 424

Trudy - Artist Jenni Viljaniemi Alan - Radio Garden Dickson - World's First Green Energy Boat Kathy - mSphereDirect video and web Rich - Deathworld Trilogy by Harry Harrison Vincent - Trump's Vaccine Panel (NYTimes), Offit's Response (Daily Beast), ASM Letter

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Jared Rice

The TWiV academia discuss induction of diarrhea by the capsid protein of an astrovirus, and association of a fungal RNA virus with white-nose syndrome of North American bats.

Become a patron of TWiV!

• Register for ASV 2017
• ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens
• Astrovirus capsid protein induces diarrhea (mBio)
• Fungal virus associated with white-nose syndrome (PLoS Path)
• Image credit
• Letters read on TWiV 423

Alan - GPS visualizer Dickson - James Webb Space Telescope and The Vertical Farm Kathy - First Snowflake Photos (One and Two) Rich - Red Mars by Kim Stanley Robinson Vincent - Carrie Fisher Fought for the Rebel Alliance and Mental Health Awareness

Ken - The Abate Lab Sean - The Death of Expertise

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories.

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Should auld infections be forgotAnd never T-cells primed?Will cross-reacting antigensProtect the host next time?

• Register for ASV 2017
• ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens
• Ten virology stories from 2016
  • Zika virus (first covered in 2015, TWiV 368)
  • Ebolavirus
  • Eukaryotic genes in Wolbachia phage (TWiV 412)
  • Harold "400" Varmus (TWiV 400) and many other guests
  • Vaccines
  • Mutualism
  • Mosquitoes and viruses
  • Vector victorious (TWiV 401)
  • Animal models of virus infections
  • Virus evolution
• Current Zika virus infections (ECDC)
• Early Zika virus infections in Hawaii (PLoS NTD)
• Zika virus vaccine for whom? (NYTimes)
• Final results for Ebola virus vaccine (Lancet)
• Photo from Mohammad
• Letters read on TWiV 422

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Alan - North America's Lost Medieval City Dickson - New Views of Pillars of Creation Kathy - Reilly Top Ten Rich - Everyday Einstein Vincent - Naples' Sleeping Volcano Might Be Waking Up

John - RadioLab: The Times They Are a-Changin'

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Nathan Letts

The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.

Become a patron of TWiV!

• Register for ASV 2017
• ASM-ASV Conference on Interplay of Viral and Bacterial Pathogens
• Chikungunya virus vaccine using insect virus platform (Nat Med)
• Ebola vaccine results (NYTimes, paper)
• Letters read on TWiV 421

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Alan - Open Access Button Dickson - National Geographic Photographs Kathy - World's Tiniest Radio Receiver Nathan - Mutter Museum, Philadelphia Vincent - How Rogue One is Connected to the Mac

Sam - Cell Lab: Evolution Sandbox Hannelore - Congressional Dish Johnye - The Fungi in Your Future Brendan - Zimmer on Longform podcast

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.

Become a patron of TWiV!

• Register for ASV 2017
• Local Zika virus transmission in Texas
• Texaszika.org
• Local dengue virus transmission in Texas (EID)
• No more Zika virus transmission in Florida (FL DOH)
• Dengue virus antibodies enhance Zika virus infection (Clin Trans Imm)
• Infectious, replication incompetent influenza virus vaccine (Science)
• Pyrrolysl-tRNA synthetase (Biochem Biophys Acta)
• History of nonsense suppression (Stan Maloy)
• Suppression of poliovirus amber mutant (Cell)
• Remembering mumps (PLoS Path)
• Letters read on TWiV 420

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Alan - Superbugs game Dickson - Dinosaur tail trapped in amber Rich - Earth's Rotation is Slowing (original article)Kathy - Lithium Ion batteries (one and two) Vincent - Truth and Lies in the Age of Trump (virology blog) and self driving Uber car

Steve - New York City Street Tree Map Justin - Transmissible vaccines?

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus.

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• Microcephaly associated with Zika virus infection in Colombia (MMWR)
• Virophage genome integration and activation by superinfection (Nature)
• Don Nelson interview (pdf)
• Page view and h index for paper rank (PLoS One)
• Credit for image of C. roenbergensis
• Letters read on TWiV 419

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Alan - Lab Wars Dickson - Star in a Jar Fusion Reactor Rich -You're a Bee. This is What it Feels Like.Kathy - List of Potential Predatory Journals Vincent - CRISPR Patent Trial Begins

Drake - Spinzall Katreya - Periodic Videos Pritesh - Smallpox in mummy

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor.

Become a patron of TWiV!

• New mouse model for MERS (Nat Micro)
• RNA-guided genome engineering (Science)
• Photo by Finny
• Letters read on TWiV 418

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 27:50

This show is sponsored by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. This Holiday season give someone a Drobo to keep all their files and memories safe forever. TWiV listeners can save 20% or more off of their purchase of a Drobo 5D, Drobo 5Dt, Drobo 5N, or any 8-drive or 12-drive system at www.drobostore.com by December 31, 2016 using discount code MICROBE20.

Register for ASV 2017 at Madison, Wisconsin

Alan - Human population through time Dickson - Every Orbit Cassini Has Taken Rich - OK GO: Walk Her WalkKathy - Medieval Bestiary Online Vincent - Can You Out-Science an Eighth Grader? and Stitchen Pox

Hannah - Bioart and Bacteria

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guest: Gary Nabel

Vincent speaks with Gary Nabel, Chief Scientific Officer at Sanofi and former Director of the Vaccine Research Institute of NIAID, about his career and his work on HIV vaccines.

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• World AIDS Day
• Video of this interview (YouTube)

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The Fellowship of the Virus trace the early history of HIV in North America, based on genome sequences obtained from late 1970s archival sera, which also reveal that Gaetan Dugas was not Patient Zero.

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• WHO: Zika virus is no longer a PHEIC
• World AIDS Day
• Early HIV/AIDS history in North America (Nature)
• Dugas was not AIDS patient zero (virology blog)
• Image credit
• Letters read on TWiV 417

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Register for the 2017 ASM Grant Writing Online course.

Alan - VP8SGI Dickson - New leaf-shaped spider discovered Rich - Dance of Earth and Venus About the SunKathy - Cultivar Series, Mutatoes, Uli Westphal site Vincent - Kung Fu Mantis vs Jumping Spider

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The multi-dimensional TWiV-brane bring you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!).

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• Predators allow virus infection of endosymbiont (PNAS)
• Image credit
• Letters read on TWiV 416

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:34:40

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 5:05

Register for the 2017 ASM Grant Writing Online course.

Alan - Cubes in Space Dickson - The Architecture of Eden by H. Pearlman and A. Whalley Rich - Studying the building blocks of life in stereo (original paper)Kathy - Ancient bottom wipes yield evidence of diseases (original paper) Vincent - Iguana vs snakes

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Jeremy Luban, Aaron Lin, and Ted Diehl

Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.

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• Ebola virus glycoprotein with increased infectivity (Cell)
• Effect in cells of Ebola virus mutations from West African outbreak (Cell)
• Ebola virus in semen for over 500 days (Clin Inf Dis)
• Puzzling origin of 2014 Ebola virus outbreak (J Virol)
• Mutant Ebola virus may have caused explosive outbreak (Goats and Soda)
• Virus Genomics and Evolution website

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:05:40

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35

Register for the 2017 ASM Grant Writing Online course.

Jeremy – Real time tracking of Ebola virus evolutionTed - The Brain Scoop Aaron - Kate Rubins sequencing DNA on ISS (video) Alan – A Sand County Almanac by Aldo Leopold Rich – Vendee GlobeKathy – Axios Vincent – Vendors from above by Loes Heerinck

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Host: Vincent Racaniello

Guest: Michael Diamond

Michael Diamond visits the TWiV studio to talk about chikungunya virus and his laboratory's work on a mouse model of Zika virus, including the recent finding of testicular damage caused by viral replication.

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• Chikungunya virus chronic joint disease caused by adaptive response (J Virol)
• Mouse model of Zika virus pathogenesis (Cell Host Micr)
• Zika virus infection during mouse pregnancy (Cell)
• Zika virus infection damages mouse testes (Nature)
• Uveitis and Zika virus in tears in mice (Cell Rep)

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Register for the 2017 ASM Scientific Writing and Publishing Online Course.

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Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex

Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry

From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.

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• EIDA2Z meeting
• MERS-CoV infection of Alpaca (EID)
• Origins of HAV in small mammals (PNAS)
• WHO recommendations on influenza vaccine composition
• Collaborative Cross mice
• Video of this episode at YouTube

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Mark Fuccio

The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell.

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• Zika virus in vaginal secretions (EID)
• Zika virus in semen (EID)
• Eukaryotic genes in a bacteriophage (Nat Commun)
• Seth Bordenstein on TWiV 332
• DNA tumor virus oncogenes antagonize cGAS-STING (Science)
• Letters read on TWiV 412

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Mark - EFN Enterprise Futures Network and Mission Log Podcast Alan - 2016 Wildlife Comedy Photography Rich - ZuTA, portable robotic printerKathy - How LEGO help blind people see Vincent - Airplane photos of Mike Kelley

Hannah - Frozen Flow Glass (Instagram)

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.

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• MicrobeTV Store
• Florida DOH Daily Zika Update
• Zika virus in new Miami neighborhood (CNN, NYTimes)
• NDV vaccine virus in wild birds (PLoS One)
• Protein cell receptor for murine norovirus (Science, PNAS)
• Poliovirus receptor analysis (J Virol)
• Letters read on TWiV 411

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Alan - Braincraft Rich - Now is the Greatest Time to Be AliveKathy - CRISPR/Cas9 by A Capella Science Vincent - Microbes After Hours: The Necromicrobiome

Jolene - Chalk Talk Science by Dennis Mangan

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Guests: Sharon Isern and Scott Michael

Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.

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• Live at Florida Gulf Coast University (TWiV #111)
• Florida DOH Daily Zika Update
• Regional Zika update, Americas (PAHO, WHO)
• NJ Zika Bill
• Dengue virus antibodies enhance Zika virus infection (bioRxiv)
• First detection of Zika virus in Brazilian A. aegyptii (Mem Inst Oswaldo Cruz)
• 2017 ASM Scientific Writing and Publishing Online Course
• Letters read on TWiV 410

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Sharon - Zika virus comics and cartoons and Florida weekly arbovirus reportsScott - Real-time tracking of Zika virus evolution Alan - Evolution of antibiotic resistance on a mega plate Rich - WindytvKathy - Zika virus map and timeline Vincent - Ohsumi Nobel advanced information and HR 5325 funding breakdown

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Guest: Jeremy Luban

Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.

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• No recovery in PACE trial (virology blog)
• The real PACE data (virology blog)
• Contagious Thinking
• Florida DOH daily Zika update
• Congress does not fail on Zika (NPR)
• Nef history (Luban lab)
• Nef excludes SERINC from virions (Nature)
• SERINC counters Nef (Nature)
• ASM Grant Writing Online Course
• Letters read on TWiV 409

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 28:50

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Alan - Migration in MotionDickson - Beautiful Chemistry Rich - XKCD Timeline of Earth Temperature Kathy - Vaccine Heroes from Vaccine Education CenterJeremy - CIDRAP posters and Demon in the Freezer Vincent - People Peas and Pathogens

Matlock - Science isn't broken

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Hosts: Vincent Racaniello and Alan Dove

Guest: David Quammen

Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.

Watch this episode at YouTube

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• David Quammen's website
• Spillover by David Quammen
• Threading the NEIDL (TWiV 200)
• The NEIDL at Boston University

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis

In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.

View video of this episode at YouTube

Become a patron of TWiV!

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guests: Dirk Dittmer, Cary Moody, Nat Moorman, Nancy Raab-Traub, Lishan Su, and Jennifer Webster-Cyriaque

In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists.

View video of this episode at YouTube

Become a patron of TWiV!

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV team discussed eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.

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• Florida DOH daily Zika update
• Congress fails again on Zika (NY Times)
• Culex pipiens does not support Zika virus replication (EID)
• Zika virus in the eye (Cell Rep)
• Norovirus replication in enteroids (Science)
• Norovirus replication in B cells (TWiV 312)
• Baylor press release
• Norovirus replication in B cells confirmed (Antiviral Res)
• Letters read on TWiV 406

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Alan - Infective PerspectiveDickson - The Living RiverRich - Freddy Mercury around the Sun Kathy - A Day in PompeiiVincent - Spraying Pesticides

Ricardo - Why the metric system mattersEric - The Giving Plague by David Brin

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth's virome by mining existing metagenomic sequence data.

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• Roger Tsien, 64 (UC San Diego Health)
• CDC running out of Zika money (NYTimes)
• Zika virus in Miami mosquitoes (NYTimes)
• No Zika virus in Rio Olympics (NYTimes)
• Vertical transmission of Zika virus in Aedes aegypti (AJTMH)
• Uncovering Earth's virome (Nature)
• Image credit (Global water volume)
• Letters read on TWiV 405

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Alan - The VizziesDickson - NASA Spinoff Kathy - Maps.meVincent - Zika: The Emerging Epidemic by Donald McNeil

Tarwin - Darwin's Radio by Greg Bear (paper or Kindle)Bodham - The start of scientific publishing, 1665

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.

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• FluMist problem (FDA)
• DA Henderson obituary (NY Times)
• DA Henderson, smallpox eradicator (TWiV Special)
• Efficacy of VZV vaccine (Ther Adv Vaccines)
• Zika virus burden, Puerto Rico (JAMA)
• Zika virus in Miami Beach (STAT)
• Congenital brain anomalies and Zika virus (Radiology)
• Congenital Zika syndrome with arthrogryposis (BMJ)
• Multicomponent animal virus from mosquitoes (Cell Host Microbe)
• Breaking rules of infection (NPR)
• Image credit
• Letters read on TWiV 404

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Alan - Sally Le PageDickson - Comfortably Numb by Jamie Dupuis Rich - Learned HelplessnessVincent - Virus by Marilyn Roossinck

OneTime - The Stranglers - Old CodgerSteve - A Poem About Pronunciation

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Donald "D.A." Henderson, a physician, educator, and epidemiologist who led the World Health Organization's campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox eradication effort, and what it means for the eradication of polio.

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This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.

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• Tribunal orders release of PACE trial data (Valerie Eliot Smith)
• Our request for PACE trial data (virology blog)
• GM mosquito release on ballot (NPR)
• Florida Keys Mosquito Control District on TWiV #111
• Cold chain and virus free plant based polio vaccine (Plant Biotechnol J)
• Disappointing flu vaccine effectiveness (CBC)
• ACIP votes down use of LAIV (CDC)
• LAIV as effective as inactivated flu vaccine (Ann Int Med)
• Flumist does work (NPR)
• Declining effectiveness of zoster vaccine (J Inf Dis)
• Efficacy of adjuvanted subunit zoster vaccine (NEJM)
• Risk of zoster from vaccine (J Inf Dis)
• Image credit: ViralZone
• Letters read on TWiV 403

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Alan - To Scale: The Solar SystemRich - Route 66 Goes SolarVincent - Race for a Zika Vaccine by Siddhartha Mukherjee

Bohdan - Penn and Teller on VaccinationsBill - Connections, Episode 1

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.

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• Marian Horzinek, 80 (ProMedMail)
• Polio in Nigeria (Atlantic, Stat, ProMedMail)
• Zika virus spreads in Miami (NYTimes)
• More Zika virus vaccines (Science)
• Back to work on Zika, Congress ! (Asbury Park Press)
• Lack of funding will stymie Zika vaccines (Wash Examiner)
• FDA OK on genetically modified mosquitoes (FDA)
• CMV attracts aphid vectors (TWiV #70)
• CMV attracts pollinating bumblebees (PLoS Path)
• Earth dwarfed by solar flare (jpg)
• Letters read on TWiV 402

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Alan - Solar storm that launched US space weather scienceRich - Data storage on DNA Dickson - Perseid meteor show liveVincent - In the Company of Microbes by Elio Schaechter

Neva - I Contain Multitudes by Ed YongAmanda - American Gut

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.

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• Beverly Griffin, 86 (1 2 3)
• Zika virus in the US (CDC)
• Zika virus spreading in Miami (CDC)
• Zika virus in Florida (NY Times)
• NIH begins phase I trial of Zika virus DNA vaccine (NIAID)
• Mosquito salive enhances West Nile replication in mice (J Virol)
• Mosquito bites enhance virus infection (Immunity)
• Photo of A. aegyptii and mouse ears from Marieke Pingen
• Letters read on TWiV 401

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Alan - The DoubleclicksKathy - WHO ZIKV app and ZIKV Giant Microbe Dickson - Photographer Rosamond PurcellVincent - Spillover: Zika, Ebola, and Beyond

Ricardo - Portugal Four Days on Renewable EnergyFatma - DeNovo: Predicting virus-host protein interactionsStephen - How mosquitoes use six needles to suck your blood

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Harold Varmus

The TWiV team is together in New York City for a conversation with Nobel Laureate Harold Varmus about his remarkable career in science.

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• Varmus Laboratory
• Varmus and Kandel on Charlie Rose (transcript)
• Rescuing biomedical research
• Letters read on TWiV 400
• Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode was made possible by PLoS Pathogens - the leading Open Access journal to publish breakthroughs in understanding pathogens and their interactions with host organisms and each other. PLOS Pathogens fosters the open exchange of ideas across fields, publishing original research on viruses, bacteria, fungi, parasites, and prions. For more information, check out www.plospathogens.org

Alan - A year on EarthRich - TWiV #1: West Nile Virus Dickson - Chasing storms, chasing beautyKathy - Bioartography and FASEB image and video competitionVincent - The Art and Politics of Science by Harold Varmus (free download)

Trudy - Scientific Studies on Last Week Tonight with John Oliver

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta.

• Zika virus disease in the US (CDC)
• Female to male Zika virus transmission (CDC)
• Zika virus in female genital tract (Lancet)
• Zika virus transmission in Utah (CDC and NYTimes)
• Olympic Zika virus risk (CDC)
• 15 companies on Zika virus vaccines (WSJ)
• Zika virus DNA vaccine in mice (Nature)
• Zika virus disease in Colombia (NEJM)
• Dengue virus antibody dependent enhancement of Zika virus (PNAS)
• Zika virus antibodies enhance dengue virus disease (Science)
• Zika virus in human placenta and developing brain (bioRxiv)
• Zika virus targets different human placenta cells (Cell Host Microbe)
• Letters read on TWiV 399

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

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Alan - CDC postmortem on Ebolavirus outbreakRich - Refutations to anti-vaccine memes (Twitter, Facebook) Dickson - History of urbanizationVincent - How to cut subject from background in Photoshop

Marion - Skeptics Guide to the Universe podcastJennie - Leatherback turtles in Costa Rica

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Host: Vincent Racaniello

Guest: Sandy Weller

Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation and cleavage and packaging of viral DNA genomes.

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• Cell killing by avian leukosis virus (Sandy's first paper, J Virol)
• ND10 protein and herpes simplex virus replication (J Virol)
• Recombination promoted by DNA viruses (Ann Rev Micro)
• HSV-1 and DNA damage response (Fut Virol)
• Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guest: David Tuller

Vincent speaks with David Tuller about flaws in the U.K's $8 million PACE trial for chronic fatigue syndrome, and efforts to have the trial data released.

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• Science and journalism (TWiV 111)
• Chronic fatigue syndrome and the CDC (virology blog)
• PACE trial (Lancet)
• Trial by error part one, two, three (virology blog)
• PACE economics analysis (PLoS One)
• All articles by David Tuller at virology blog
• Valerie Eliot Smith's blog
• Karina Hansen, prisioner of Denmark

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

Host: Vincent Racaniello

Guest: Peter Palese

Vincent speaks with Peter Palese about his illustrious career in virology, from early work on neuraminidases to universal influenza virus vaccines.

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• Palese Laboratory
• Pig kidney neuraminidase (Hoppe Seylers Z Physiol Chem)
• DNAse in cytoplasmic DNA virus (Virology)
• Inhibitor of influenza virus neuraminidase (Virology)
• Influenza neuraminidase defective mutants (Virology)
• Swine influenza virus of 1976 RNA pattern (Nature)
• 1977 influenza H1N1 similar to 1950s strains (Nature)
• H5N1 influenza: Facts, not fear (PNAS)
• Influenza HA stalk immunity in ferrets (J Virol)

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guest: Stephen J. Russell

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.

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• Hokies go viral (TWiV 285)
• MV NIS de Myelo (TWiV 298)
• Remission of disseminated myeloma after MV treatment (Mayo Clin Proc)
• miRNA detargeting (J Virol)
• Video of this episode at YouTube

This episode is sponsored by CuriosityStream. Get two months free when you sign up at curiositystream.com/microbe and use the promo code MICROBE.

Kathy - Can you explain your science in 30 seconds? and How Far Can We Go?Rich - Small asteroid Earth's companionVincent - The Gene by Siddhartha Mukherjee

Dylan - Microsculpture by Levon Biss (website)

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Hosts: Vincent Racaniello and Alan Dove

Guest: Erica Ollmann Saphire

Vincent and Alan speak with Erica about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.

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• Structure of antibodies bound to Ebola virus glycoprotein (PNAS)
• Structure of cross-reactive filovirus antibody (Cell)
• Multiple functions of Ebola virus VP40 protein (Cell)
• View video of this episode on YouTube
• Letters read on TWiV 394

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

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• Late sexual transmission of Zika virus (Lancet)
• Zika virus disease in US (CDC)
• Zika virus lab accident (ABC News)
• Mosquito eradication (virology blog)
• Florida mosquito control (TWiV 111)
• How tequila mosquito (TWiV 178)
• SEC14L2 allows HCV replication in cell culture (Nature)
• Lipid peroxidation (Wikipedia)
• HCV replicase regulated by lipid peroxidation (Nat Med)
• Letters read on TWiV 393

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Host: Vincent Racaniello

Guests: Michael Diamond, Michaela Gack, Laura Kramer, and Charles Rice

Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC.

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