This Week in Virology

In his weekly clinical update, Dr. Griffin discusses the recent increase in norovirus outbreaks, human cases of H5N1 avian influenza, before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections, the WasterwaterScan dashboard, where to find PEMGARDA, how effective Molnupiravir is and provides information for Columbia University Irving Medical Center's long COVID treatment center.

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• Norovirus: Waste water scan for 11 pathogens (WastewaterSCan)
• Adolescent with Influenza A H5N1 infection (NEJM)
• Highly pathogenic avian Influenza A ( H5N1) virus infections in humans (NEJM)
• Emerging threat of H5N1 to human health (NEJM)
• US respiratory virus activity (CDC Respiratory Illnesses)
• In-hospital outcomes of healthcare-associated Coronavirus Disease 2019 (Omicron) versus healthcare-associated Influenza (CID)
• Waste water scan for 11 pathogens (WastewaterSCan)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Weekly surveillance report: cliff notes (CDC FluView)
• RSV: Waste water scan for 11 pathogens (WastewaterSCan)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Real clinical effectiveness of Molnupiravir against 30-day mortality (OFID)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)Post-COVID Condition Risk Factors and Symptom Clusters and Associations with Return to Pre-COVID Health (CID)
• Letters read on TWiV 1180
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews RFK Jr's demand to revoke polio vaccine, Wuhan lab samples do not include close relatives to SARS-CoV-2, using artificial intelligence to discover the RNA virosphere, and biomarkers that discriminate early and late phases of respiratory virus infections from a SARS-CoV-2 human challenge study.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Angela Mingarelli

Subscribe (free): Apple Podcasts, RSS, email

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• Support science education at MicrobeTV
• ASV 2025
• RFK Jr lawyer wants revocation of polio vaccine (CNN)
• Wuhan lab has no samples close to SARS-CoV-2 (Nature)
• Using AI to discover RNA virosphere (Cell)
• SARS-CoV-2 human challenge reveals biomarkers (Nat Comm)
• Does this challenge study pass the smell test? (TWiV 863)
• Letters read on TWiV 1179
• Timestamps by Jolene. Thanks!

Angela – Science's 2024 breakthrough of the year, Lenacapavir "the long shot". NEJM papers with Lenacapavir trials: one and two. Kathy – Bach Toccatta and Fugue on floor piano Rich – Never Cry Wolf Vincent – Common Raven and American Crow

Jaan – Meute (one, two, three)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin deep dives into the whooping cough epidemic and bird flu in big cats, and in conjunction with your host Vincent Racaniello discusses the recent case of paralytic poliomyelitis in Israel, measles outbreaks and HHS campaign for vaccine safety campaign before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if the COVID mRNA vaccine is effective against symptomatic SARS-CoV-2 infection and hospitalization in children, where to find PEMGARDA, information for Columbia University Irving Medical Center's long COVID treatment center, how long COVID effects one's activities, personality and neuropsychiatric symptoms.

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• Highest level of whooping cough cases in a decade (NBC News)
• Provisional pertussis surveillance report (CDC)
• Polio moves into Israel (Jerusalem Post)
• Polio today (GPEI)
• Measles- the let's get real vaccination campaign (CDC)
• Measles fact sheet (CDC)
• Measles- near you (CDC)
• Let's get real about childhood vaccines (HHS)
• The FACTS about childhood vaccines (HHS)
• Tigers and cougars dying from bird flu, oh my! (NY Times)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Waste water scan for 11 pathogens (WastewaterSCan)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Weekly surveillance report: cliff notes (CDC FluView)
• Burden of all-cause mortality following Influenza-associated hospitalizations (CID)
• Waste water scan for 11 pathogens (WastewaterSCan)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Initial effectiveness of mRNA-1273 against SARS-CoV-2 infection and hospitalization in young children (OFID)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• Long COVID and significant long COVID–associated activity limitation among adults
• (CDC: MMWR)
• 2024 Update of the RECOVER-Adult Long COVID Research Index (JAMA Network)
• About 8% of US adults have ever had long COVID, survey finds(CIDRAP)
• Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents (eClinicalMedicine)
• Personality and neuropsychiatric symptoms in individuals diagnosed with long COVID(BMC Infectious Diseases)Post-COVID Condition Risk Factors and Symptom Clusters and Associations with Return to Pre-COVID Health (CID)
• Letters read on TWiV 1178 38:11
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

At the School for Influenza in Brisbane, TWiV speaks with Kirsty, Erik and Rebecca about their careers and their research.

Host: Vincent Racaniello

Guests: Kirsty Short, Erik Karlsson, and Rebecca Cox

Subscribe (free): Apple Podcasts, RSS, email

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• Support science education at MicrobeTV
• Diabetes, obesity, and COVID-19 severity (Diab Care)
• Rice farming and zoonosis in Cambodia (One Health)
• Influenza correlates of protection (mBio)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin continues his discussion of whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses how routine childhood immunizations especially that against poliovirus are threatened by Robert F Kennedy Jr and Aaron Siri, the origin of the SAR-CoV-2 virus and retraction of Didier Raoult's research, then returns to discussing the first case of severe disease following H5N1 infection in humans and the state of California's "bird flu emergency", the benefit of the measles vaccine, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how vaccination reduced hospitalization of children between 5-17 years, the ACIP recommendation for the immunocompromised, where to find PEMGARDA, information for Columbia Unversity Irving Medical Center's long COVID treatment center, long COVID in cancer patients and the physical malaises of long COVID.

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• Mystery disease in DRC kills mostly children (ALJAZEERA)
• Malaria—mysterious disease in DRC? (ALJAZEERA)
• Mysterious disease in DRC is severe malaria (ALJAZEERA)
• Confirmed first severe human H5N1 case (CIDRAP)
• California declares bird flu emergency (Reuters)
• RFK's lawyer asks FDA to revoke approval of the polio vaccine (NY Times)
• NO WAY! Vaccination promotes survival and health? (LANCET)
• 10.6 million cases of measles this year alone! (WHO)
• 20% rise in measles…..(NY Times)
• No Sars-CoV-2 relatives in Shi Zhengli's freezers (Nature)
• Controversial COVID study that promoted unproven treatment retracted after four-year saga (Nature)
• Influenza weekly surveillance report: clift notes (CDC FluView)
• Waste water scan for 11 pathogens (WastewaterSCan)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• US respiratory virus activity (CDC Respiratory Illnesses)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• BNT162b2 XBB Vaccine for COVID-19 Among Children 5-17 Years ofAge (JAMA Network)
• ACIP recommendations for those over 65 years and those under 6 months who are immunocompromised (CDC MMWR)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• Post-acute sequelae of COVID-19 in cancer patients: Two cohorts in UK and Hong Kong(Cancer Medicine)
• Skeletal muscle adaptations and post-exertional malaise in long COVID (Cell: Trends in Endocrinology & Metabolism)
• Letters read on TWiV 1176
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews the appearance of poliovirus in Europe, mystery disease in DRC, global burden of Chikungunya, viruses of parasitic nematodes that induce antibody responses in vertebrate hosts, and picobirnaviruses, do they infect eukaryotes or prokaryotes?

Hosts: Vincent Racaniello, Alan Dove, and Jolene Ramsey

Subscribe (free): Apple Podcasts, RSS, email

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• ASV 2025
• Write your senators about RFK Jr
• Support science education at MicrobeTV
• Poliovirus in Europe (WHO)
• DRC mystery disease (Reuters)
• Global burden of chikungunya (BMJ Global Health)
• RNA viruses of parasitic nematodes (Nat Micro)
• Picobirnaviruses encode bacterial lysins (PNAS)
• Prokaryotic ribosome binding site in picobirnavirus genome (Virology)
• Letters read on TWiV 1175
• Timestamps by Jolene. Thanks!

Alan – Sondehub and radiosonde hunting Jolene – Book "10 to 25: The Science of Motivating Young People" By David Yeager Vincent – Dr. Vinay Prasad "Sabotaging RFK Jr's Confirmation Will Increase Vaccine Hesitancy" & "Doctors Criticizing RFK Jr. Paved the Way for His Ascendancy"

Syl – Foldscope Jennifer – minutiae

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin deep dives into whether the mysterious respiratory illness in the Congo is malaria, and in conjunction with your host Vincent Racaniello discusses the failure of the poliovirus eradication campaign with virus circulation detected throughout Europe and how we should focus on disease control not virus circulation, then returns to discussing avian influenza in raw milk and the early stoppage of the mpox antiviral Tecovirimat before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, and information for Columbia Unversity Irving Medical Center's long COVID treatment center.

Become a patron of TWiV!

• IIs the mysterious disease in the Congo, malaria? (AP News)
• State of global health, year-end remarks by WHO director-general (WHO)
• Really, progress towards poliomyelitis eradication? (CDC MMWR)
• Increases in confirm cases ¹ control of poliomyelitis (WHO)
• Polio European Union and United Kingdom, is that 1 global entry? (Science)
• Is the WHO the global CDC? polio vaccination guidelines (WHO)
• Do you feed your cats raw milk? (Public Health LA county)
• Is there avian influenza in the zoo near you? (Maricopa)
• Don't feed your cat raw milk (CIDRAP)
• Holy Cow! H5N1 in cows! (microbeTV)
• Tecovirimat no improvement in Mpox resolution or pain(NIAID NIH)
• Interim results from STOMP study of Tecovirimat (SIGA)
• Trial stops enrollment after Tpoxx fails (CIDRAP)
• Is Tecovirimat really first-in-class mpox therapy? (Viruses)
• Influenza weekly surveillance report: clift notes (CDC FluView)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Waste water scan for 11 pathogens (WastewaterSCan)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine)
• Phase III trial results! Comparative efficacy and safety of COVID-19 (BMC Infectious Diseases)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Stop playing favorites with COVID-19 in healthcare settings (Infection Control & Hospital Epidemiology)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• Letters read on TWiV 1174
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews nominees to head NIH, FDA, and CDC, cervical cancer decline following HPV vaccination, local dengue in Texas, human isolate of H5N1 virus is transmissible and virulent in animal models, and shared mechanisms of immune evasion among animal and bacterial viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey

Subscribe (free): Apple Podcasts, RSS, email

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• Bhattacharya nominated to head NIH (Science)
• Makary nominated to head FDA (Science)
• Weldon nominated to head CDC (Chief Healthcare Exec)
• Cervical cancer declining following vaccination (JAMA Net)
• Local dengue case in Texas (Texas HHS)
• H5N1 human isolate transmissible and virulent (Nature)
• H5 current situation (CDC)
• Global H5N1 cases (Our World in Data)
• Conserved immune evasion in animal and bacterial viruses (Cell)
• Timestamps by Jolene. Thanks!

Brianne – Pale Blue Pod Kathy – PhysicsGirl recent Instagram post, ScienceAdvisor signup free daily sci news distillation, Semi-conducting hydrogels, Bot that can pick up things with a soft touch, "Pigeonbot II", a drone called LisRaptor, zapping forever chemicals like PFAS with light and here Rich – Vendee Globe Jolene – Center for the Improvement of Mentored Research Experiences Vincent – These two ancient human relatives crossed paths 1.5 million years ago

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin summarizes influenza and RSV circulation in the US, the benefit of administering oseltamivir early and if influenza vaccination reduces secondary household infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how 1st or 2nd trimester SARS-CoV-2 infections may shorten newborn telomeres, what are B1 cells, if IgG4 responses are critical for protection elicited by mRNA vaccines, if there is a difference in protection against the development of severe disease between an mRNA or a protein based vaccine, where to find PEMGARDA, if remdesivir reduces readmission of vulnerable patients once hospitalized for COVID-19, information for Columbia University Irving Medical Center's long COVID treatment center, if transcutaneous electrical nerve stimulation ameliorates musculoskeletal pain and fatigue during long COVID, do antihistamines reduce post-acute sequelae of SARS-CoV-2 infection and how long can SARS-CoV-2 antigens be detected in blood.

Become a patron of TWiV!

• Influenza weekly surveillance report: cliff notes (CDC FluView)
• US respiratory virus activity (CDC Respiratory Illnesses)
• Influenza vaccines protect against secondary infections in households (JAMA Network)
• Benefit of early oseltamivir therapy for influenza A (CID)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Maternal infection of SARS-CoV-2 during 1st and 2nd trimesters newborn telomere shortening (Journal of Translational Medicine)
• What is a B1 cell? (Wikipedia)
• Pre-COVID and post-COVID vaccination on long COVID (Journal of Infection)
• Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies after BNT162b2 Vaccination in Children (The Pediatric Infectious Disease Journal)
• Relative effectiveness of homologous NVX-CoV2373 and BNT162b2 COVID-19 vaccinations in South Korea (Vaccine)
• Phase III trial results! Comparative efficacy and safety of COVID-19 vaccines (BMC Infectious Diseases)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients Hospitalized for COVID-19 (CID)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• Transcutaneous electrical nerve stimulation for fibromyalgia-like syndrome in patients with Long-COVID(Scientific Reports)
• Mitigating the risks of post-acute sequelae of SARS-CoV-2 infection (PASC) with intranasal chlorpheniramine (BMC Infectious Diseases)
• Measurement of circulating viral antigens post-SARS-CoV-2 infection (CID)
• Letters read on TWiV 1172
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews susceptibility to vaccine-preventable infections in asylum seekers, the economic power of vaccines, French university tries to bury its investigation of a faculty member's ethical lapses, transmission dynamics of SARS-CoV-2 in New Zealand before and after COVID-19, and a germ line encoded antibody that recognizes a broad array of enveloped viruses.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Subscribe (free): Apple Podcasts, RSS, email

Become a patron of TWiV!

• Why RFK Jr is not suitable for HHS (YouTube)
• Write your Senators to oppose RFK Jr
• Support MicrobeTV
• ASV 2025
• Susceptibility to infections in asylum seekers (NEJM)
• RSV hospitalization in adults (JAMA Net Open)
• Ethics failings at French university (Science)
• RSV transmission in New Zealand (Nat Commun)
• Glycan reactive IgM binds multiple viruses (SciImmunol)
• Timestamps by Jolene. Thanks!

Brianne – Publication of Updated Human Cell Atlas Rich – Astroscale Alan – E3 ubiquitin ligase game, and an article about its origin Vincent – In the Quantum World, Even Points of View Are Uncertain

Ryan – A Dangerous Moment

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is "adapting" for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the 'seat belt' of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving!

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• Influenza weekly surveillance report: cliff notes (CDC FluView)
• US respiratory virus activity (CDC Respiratory Illnesses)
• RSV-Network (CDC Respiratory Syncytial virus Infection)
• In case you missed, US respiratory virus activity (CDC Respiratory Illnesses)
• Adaptation of H5N1 to humans…..sequence analysis (Nature)
• Favoring human transmission for H5N1 ?(Youtube: medcram)
• From 2022: unprecedented bird flu outbreaks sweeping the world…..and we are still talking about it? (Nature)
• What children get flu: First child in US infected with H5N1 (CDC Newsroom)
• Bird flu detected in raw milk……but RFK at HHS says it is safe? (NBC News)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• If I see no one in my house, household Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission is reduced! (CID)
• Updated boosters conferred protection against SARS-CoV-2 infection and emergency visits/hospitalizations during a JN.1 variant wave(CID)
• Provisional COVID-19 mortality (CDC National Center for Health Statistics)
• Influenza, RSV and COVID-19 vaccine in nursing home residents (CDC MMWR)
• Vaccines are the seat belts of public health (TRID)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Effectiveness of molnupiravir against 30-day mortality among 74 541 SARS-CoV-2 positive patients (OFID)
• Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo(JAMA Network Open)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir for treatment of COVID-19 requiring oxygen support (CID)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Neurologic manifestations of long COVID disproportionately affect young and middle-aged Adults (Annals on Neurology)
• To review, three score and two months ago, the WHO brought for on this planet, the declaration of SARS-CoV-2/COVID-19….
• How nature began a pandemic (microbeTV)
• Bullying within the origin scientific discourse……by those at Rutgers (Science)
• Scientific harassment on the rise (Science)
• Doxing :The de-identified of the de-identified (Wikipedia)
• Harassment survey (Science)
• The harm of factless hypotheses (mSphere)
• In summary, the era of harm: factless theories (microbeTV)
• Stay inside: risk of SARS-CoV-2 transmission in community indoor settings (JID)
• Lower levels of household transmission of SARS-CoV-2 VOC Omicron compared to Wild-type: an interplay between transmissibility and immune status (JID)
• Long COVID hotline (Columbia : Columbia University Irving Medical Center)
• Letters read on TWiV 1170
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV travels to Brisbane, Australia for the Options XII for the control of influenza conference, and meets up with Stephanie Gras and Jenna Guthmiller to talk about their careers and their research.

Hosts: Vincent Racaniello, Kathy Spindler, and Steph Langel

Guests: Stephanie Gras and Jenna Guthmiller

Subscribe (free): Apple Podcasts, RSS, email

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• Goldilocks zone of influenza immunity (J Inf Dis)
• Broadly neutralizing HA antibodies (Nature)
• T cell epitopes needed for influenza vaccines (Clin Transl Immunol)
• T cell epitopes conserved in emerging H5N1 viruses (Clin Transl Immunol)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin briefly discusses the E.coli outbreak associated with onions from McDonald's before deep diving into the announcement of Robert F Kennedy Jr. nomination for Secretary of Human and Health Services with highlights from MicrobeTV's own Vincent Racaniello and Paul Offit (Beyond the Noise), the global measles outbreak, underutilization of influenza antivirals for children and teens, the $350 million 2025 order for mpox vaccination, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, the effectiveness of N95 mask, the interplay between transmission and immunity for virus spread, where to find PEMGARDA, and translational science being conducted to understand long COVID including ongoing clinical trials, development of animal models and how sex may affect outcomes.

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• Micky D's onions linked to E. coli outbreak….another reason to not eat fast food (CDC)
• RFK Jr. series…..does he get anything right? (FactCheck.org)
• Salk polio vaccine : a calculated risk? (BMJ)
• How to conduct a controlled vaccine trial (American Journal Public Health Nations Health)
• Safety and efficacy of BNT162b2 mRNA COVID-19 vaccine (NEJM)
• Another Safety and efficacy study: mRNA-1273 SARS-CoV-2 vaccine (NEJM)
• …..SERIOUSLY! can't RFK Jr get it correct? (FactCheck.org)
• 'I've Come Home Today': RFK Jr. (the Defenders Children's Health Defense News & Views)
• Thank God for sensible people: Racaniello and Offit (microbeTV)
• RFK Jr. : MAN CAN'T YOU GET ANYTHING RIGHT? (Annenberg Public Policy Center: University of Pennsylvania)
• No harm in repeating Vinny! Thank God for sensible people: Racaniello and Offit (microbeTV)
• Did America think Trump-Kennedy through? …..really did you think this through? (microbeTV)
• Make American Healthy Again? ……I will have fries with that….SUPERSIZED! (Wall Street Journal)
• Keep the United States HEALTHY! (Safe Communities Coalition)
• Measles in the US (CDC Measles: Rubeola)
• The merry-go-around of measles (JID)
• It is a measles outbreak! (CDC Measles: Rubeola)
• 10.3 million measles infections in 2023….but no vaccine (WHO)
• Underutilization of influenza antiviral treatment among children and adolescents (CDC MMWR)
• Increase in influenza infection in children…..(CIDRAP)
• Influenza weekly surveillance report: clift notes (CDC FluView)
• $340 million doses of mpox vaccine ordered for 2025 (Reuters)
• Mpox in NYC (JID)
• Respiratory virus activity (CDC Respiratory Illnesses)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• N95 Filtering Facepiece Respirator use (JAMA Open Network)
• The Risk of SARS-CoV-2 Transmission in Community Indoor Settings (JID)
• Lower levels of household transmission of SARS-CoV-2 VOC Omicron compared to Wild-type: an interplay between transmissibility and immune status (JID)
• Enhanced placental antibody transfer efficiency with longer interval between maternal RSV vaccination and birth (AJOG: American Journal of Obstetrics and Gynecology)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Perceptions and Barriers to Outpatient Antiviral Therapy for COVID-19 and Influenza as Observed by Infectious Disease Specialists (OFID)
• Drug–Drug Interactions with Nirmatrelvir/Ritonavir(Infectious Diseases and Therapy)
• Drug interaction checker (University of Liverpool)
• Real-world effectiveness of nirmatrelvir-ritonavir and molnupiravir (CMI: Clinical Microbiology and Infection)
• Alleviation of COVID-19 Symptoms and Reduction in Healthcare Utilization Among High-Risk Patients Treated With Nirmatrelvir/Ritonavir (CID)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Long-COVID Clinical Trials (RECOVER)
• Initiating Long Covid RECOVERy (Science Translational Medicine)
• Beyond acute SARS-CoV-2 infection in children (Science Translational Medicine)
• Long COVID and Osler's Web: Chronic Fatigue Syndrome (goodreads)
• Sex differences in post infection sequalae (Science Translational Medicine)
• Symptoms after Lyme disease: What's past is prologue (Science Translational Medicine)
• Animal models of Long COVID (Science Translational Medicine)
• Therapies for Long COVID (Science Translational Medicine)
• Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution (Science Translational Medicine)
• The Long COVID ISSUE (Science Translational Medicine)
• Letters read on TWiV 1168
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reveals a novel H5N1 reassortant virus in Cambodia, circulating vaccine derived poliovirus type 2 in more countries, circulation in the blood of humans of infectious parvovirus B19 coated with active proteases, and B cell receptor dependent enhancement of dengue virus infection.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

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• MicrobeTV Discord Server
• MicrobeTV Fundraiser
• Novel H5N1 in Cambodia (medRxiv)
• More cVDVP2 circulation (polioeradication.org)
• Infectious parvovirus B19 with proteases (Nat Comm)
• B cell receptor enhancement of dengue disease (PLoS Path)
• Timestamps by Jolene. Thanks!

Brianne – See How Many Lives Vaccines Have Saved Around the World based on Lancet study Dickson – 2024 Wildlife Photographer of the Year Kathy – 450 Million year old arthropods preserved in fool's gold. Primary article Pyrite video Vincent – 'We need to be ready for a new world': scientists globally react to Trump election win

Jack – Coronavirus vaccine update

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin apprises us about the first case of highly pathogenic influenza in Canda, children dying of influenza infection and novel genetic reassortments of the virus, the Marburg virus outbreak in Rwanda, number of mpox infections, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how scientific mistrust has affected COVID-19 vaccine administration, resolution of the FDA hold on Novovax's combination influenza and COVID vaccine, where to find PEMGARDA, how Paxlovid SAVES you money, when to use steroids to treat COVID-19 and how trace amounts of cytokines elicted during SARS-CoV-2 infection negatively impact cardiac function.

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• Bird flu flew into British Columbia Canada (Global News Canada)
• H5N1 in British Columbia (CIDRAP)
• Highly Pathogenic Avian Influenza flies commercial and domestic (USDA)
• Countdown till the end of Marburg outbreak (WHO Rwanda)
• First kid's death due to flu (CIDRAP)
• Influenza weekly surveillance report: clift notes (CDC FluView)
• H5N1 novel reassortments in migratory birds in China (Emerging Infectious Diseases)
• Serologic evidence of recent infection with highly pathogenic avian influenza A (MMWR)
• Seriously? 50,000 mpox cases in African outbreak (CIDRAP)
• Respiratory virus activity (CDC Respiratory Illnesses)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Science trust: behind COVID 19 vaccine acceptance (Vaccine X)
• Vaccine mistrust levels are not budging (Healthday)
• FDA clinical hold lifted on Novavax's combination COVID-flu vaccine(Reuters)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Real-world effectiveness of nirmatrelvir-ritonavir and molnupiravir (CMI: Clinical Microbiology and Infection)
• Alleviation of COVID-19 Symptoms and Reduction in Healthcare Utilization Among High-Risk Patients Treated With Nirmatrelvir/Ritonavir (CID)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Secondary bacterial infection follows COVID-19 (Nature Communications)
• Daniel Griffin's evidence based medical practices for long COVID (OFID)
• Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function (Nature Medicine)
• Letters read on TWiV 1166
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV notes the passing of virologist Diane Griffin, first H5N1 influenza virus in US pigs, Innate immune control of influenza virus interspecies adaptation via IFITM3, and antiviral trained innate immunity in alveolar macrophages after SARS-CoV-2 infection reduces secondary influenza A virus disease.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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• MicrobeTV Discord Server
• MicrobeTV Fundraiser
• Diane Griffin passes (Johns Hopkins)
• Diane Griffin on TWiV 453
• First H5N1 influenza virus in US pigs (CIDRAP)
• IFITM3 controls interspecies influenza virus infection (Nat Comm)
• Trained innate immunity by alveolar macrophages (Immunity)
• Timestamps by Jolene. Thanks!

Angela – See a giant 'ghost particle' detector and more — October's best science images Brianne – October 27 APoD: Bat nebula Dickson – Nikon Small World Contest 2024 winners Kathy – AAAS 150th anniversary video, celebrating scientists and Pew's 2024 annual Trust in Science survey findings Rich – Cats Basically Are a Liquid After All, Study Confirms Alan – HHMI's Beautiful Biology site Vincent – EcoHealth Alliance Fights Back

Hunter – Don't stop me now: Queen's Brian May on saving badgers — and the scientific method Anne – Reasons to be cheerful

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about the World Health Organization research and development plan to combat endemic pathogens including hepatitis C virus, RSV and dengue virus, another case of mpox in Britian, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, if there is a benefit to additional COVID vaccinations after the initial series, ISDA guideline for using anti-SARS-CoV-2 monoclonal antibody therapy for prophylaxis, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if and how do severe secondary bacterial infections develop following SARS-CoV-2 infection, and if COVID-19 associates with a risk of autoimmune and autoinflammatory connective tissue disorders.

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• Is the WHO the world's NIH: endemic pathogens initiative (eBioMedicine)
• Another two cases of mpox in Britian (Reuters)
• How to stop Marburg virus (Rwanda Biomedical Centre)
• Marburg Virus fact sheet (Rwanda Biomedical Centre)
• Influenza weekly surveillance report: cliff notes (CDC FluView)
• RSV NETwork (CDC RSV)
• Respiratory virus activity (CDC Respiratory Illnesses)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Symptom reduction after additional vaccine dose during Omicron (OFID)
• IDSA Guideline update for SARS-CoV-2 monoclonal antibody pemivibart pre-exposure prophylaxis (CID)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Secondary bacterial infection follows COVID-19 (Nature Communications)
• Daniel Griffin's evidence-based medical practices for long COVID (OFID)
• Autoimmune and autoinflammatory connective tissue disorders following COVID-19 (JAMA Dermatology)
• Letters read on TWiV 1164
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From the 2024 International Hepatitis B virus meeting in Chicago, TWiV speaks with Mala Maini and John Tavis about their careers, the replication and transmission of HBV, and the HBV Foundation.

Hosts: Vincent Racaniello and Rich Condit

Guests: Mala Maini and John Tavis

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• MicrobeTV Discord Server
• Immunobiology and pathogenesis of hepatitis B virus infection (Nat Rev Immunol)
• HBV Foundationhttps://www.hepb.org/
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about "walking pneumonia", the phase of the polio supplemental immunization campaign in Gaza, mpox circulation, the Marburg virus outbreak in Rwanda, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, if mRNA boosters affect mucosal immunity against SARS-CoV-2 infection, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, if antiviral therapy prevents long COVID and viral sequalae in healthy young marines.

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• Mycoplasma pneumoniae infections increasing (CDC)
• Polio vaccination campaign restarts (Reuters)
• North Gaza polio campaign postponed (Reuters)
• 1St clade 1b mpox in UK (GOV.UK)
• UK imports mpox (CIDRAP)
• Clinical trial of MVA-BN for children (Bavarian-Nordic)
• How to stop Marburg virus (Rwanda Biomedical Centre)
• Marburg Virus fact sheet (Rwanda Biomedical Centre)
• Laboratory confirmed influenza associated hospitalizations 2010-2023 (CDC)
• Influenza weekly surveillance report: cliff notes (CDC FluView)
• Mucosal nirsevimab levels in breakthrough bronchiolitis (LANCET Infectious Diseases)
• RSV NETwork (CDC RSV)
• Respiratory virus activity (CDC Respiratory Illnesses)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• UK public health data tracker (UKHSA)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Repeat COVID-19 mRNA vaccination contributes to mucosa immunity (Science Translational Medicine)
• XBB.1.5 mRNA booster vaccination limited mucosal immunity (Science Translational Medicine)
• I repeat: COVID mRNA booster vaccinations suboptimal respiratory mucosal immunity (Science Translational Medicie)
• Facial Palsy after COVID-19 vaccination? (Emerging Infectious Diseases)
• New preventive COVID-19 agent (ISDA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Fusion center near you….if in NY (Prime Fusions)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Viral and symptom rebound following monoclonal antibody therapy (JID)
• Drug interaction checker (University of Liverpool)
• Nirmatrelvir plus ritonavir reduces COVID-19 hospitalization and prevents long COVID (Scientific Reports)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Time to Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo (JAMA Network Open)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Clinical and functional assessment of SARS-CoV-2 sequelae among young marines
• (LANCET: Regional Health Americas)
• Letters read on TWiV 1162
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews continuing expansion of poliovirus type 2, removal of influenza B/Yamagata from the vaccine, Nobel Prize for miRNAs, protective immune response with a adenovirus-associated virus vector expressing a computationally designed hemagglutinin, and viral gene drive during herpes simplex 1 infection in mice.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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• MicrobeTV Discord Server
• Continued expansion of type 2 poliovirus (reliefweb)
• No more polio case map at polioeradication.org
• B/Yamagata removed from flu vaccine (NPR)
• Nobel Prizes for miRNA (ScienceInsider)
• AAV-vectored influenza vaccine (J Virol)
• Herpesvirus type 1 gene drive in mice (Nat Commun)
• Timestamps by Jolene. Thanks!

Brianne – Virus and Vaccines Information Page from NIH All of Us Research Program Kathy – For a Pivotal Vaccine: Trial, Error and Two Young Lives Rich – October 17 2024 APOD: The Clipper and the Comet Alan – Opening a deep-sea vent with a crowbar Vincent – The expanding world of neuroscience

Jason – Solar eclipse on Mars and Polaris Program and their Harmony of Resilience Ryan – New York's childhood vaccine coverage remains high

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection.

Become a patron of TWiV!

• Grim marker: mpox over a 1000 deaths in Africa (CIDRAP)
• Global trend of mpox outbreak 2022-2024 (WHO)
• Second time mpox is a global public health emergency (Reuters)
• Mpox variant in Germany (Reuters)
• Epidemiological analysis of confirmed mpox cases in Burundi (EuroSurveillance)
• The 63rd case of Marburg virus infections in Rwanda (CIDRAP)
• How to stop Marburg virus (Rwanda Biomedical Centre)
• Marburg virus fact sheet (Rwanda Biomedical Centre)
• FDA approves RSV vaccine ABRYSVO for 18-59 individuals of increased risk (Pfizer)
• Respiratory syncytial virus infection-NET (CDC)
• New pneumococcal vaccine recommendations…..it's a virus? (CDC Newsroom)
• Recommending PREVNAR 20, 20 valent pneumococcal conjugate vaccine for 50 and over (Pfizer)
• And one more, CAPVEXIVE, pneumococcal 21 valent conjugate vaccine (Merck)
• Penumococcoal 21-valent conjugate vaccine CAPVEXIVE(MerckVaccines.com)
• Influenza surveillance: Key updates (CDC)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• What is happening across the pond? (UKHSA data dashboard)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Risk of SARS-CoV-2 transmission when indoors (JID)
• NVX-CoV2327 vs BNT162b2 vaccines in adolescents (Pediatric Infectious Disease Journal)
• Second dose of 2024-2025 COVID19 vaccine recommended for 65 and older (CDC Newsroom)
• New preventive COVID-19 agent (ISDA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Viral and symptom rebound following monoclonal antibody therapy (JID)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• ASH living guidelines on use of anticoagulation for thromboprophylaxis in patients with COVID-19: executive summary, Dr. Daniel Griffin (Blood Advances)
• Novel treatments for acute COVID-19 should account for long COVID (JID) The persistence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) after SARS-CoV-2 infection (Journal of Infection)
• Letters read on TWiV 1160
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden.

Guests: Niklas Björkström and Joakim Dillner

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• MicrobeTV Discord Server
• Endometrial immune system variation (Sci Immunol)
• Immune defense in the womb (News from Karolinska)
• HPV vaccination and screening for elimination (Nat Comm)
• Cervical cancer elimination strategies (Int J Cancer)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one's driving and how long COVID affects Chinese society.

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• Undiagnosed MPXV infections are high in men who have sex with men (BMC Infectious Diseases)
• WHO, now a vaccine approval agency, Jynneos for teens (CIDRAP)
• Mpox outbreak global trends (WHO)
• How to stop Marburg virus (Rwanda Biomedical Centre)
• Marburg virus fact sheet (Rwanda Biomedical Centre)
• Largest whooping cough outbreak in US in a decade (NPR)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Insurance relates to effectiveness and waning of immunity following 3rd dose of mRNA COVID-19 vaccine? (JID)
• New preventive COVID-19 agent (ISDA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• How well do you test: performance of the SARS-CoV-2 antigen rapid detection test (eBioMedicine)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir-associated survival outcomes among immunocompromised patients (CID)
• Remdesivir Effectiveness in Reducing the Risk of 30-day Readmission in Vulnerable Patients (CID)
• Measurement of circulating viral antigens post-SARS-CoV-2 infection (CMI: Clinical Microbiology and Infection)
• DUCI: driving under cognitive influence of COVID-19 (Neurology)
• Long COVID facts and findings: (LANCET: Regional Health Western Pacific)
• Letters read on TWiV 1158
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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• MicrobeTV Discord Server
• Marburg virus disease, Rwanda (WHO)
• Suspected German Marburg case tests negative (Politico)
• Cryo-EM discovery of insect parvovirus (Cell)
• Mosaic sarbecovirus nanoparticle experimental vaccine (Cell)
• Letters read on TWiV 1157
• Timestamps by Jolene. Thanks!

Brianne – ASM Lesson Plans Alan – A City on Mars, and this blog by a ham radio operator hit by Hurricane Helene Vincent – How to Win A Nobel Prize

Laura – Science of Public Communication (original article)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK's recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem.

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• Polio: second round of vaccination in Gaza (Reuters)
• Season 3 for GSK RSV vaccine protection (CIDRAP)
• Positive data for Arexvy, the respiratory syncytial virus vaccine (GSK)
• Mpox convicted felon: in Ugandan prison (Reuters)
• How to stop Marburg virus (Rwanda Biomedical Centre)
• Marburg virus fact sheet (Rwanda Biomedical Centre)
• CDC summary of the "Rwanda Marburg Situation" (CDC)
• 700 doses of a Marburg vaccine from the Sabin Vaccine Institute to Rwanda (CIDRAP)
• USAID mobilizes Marburg outbreak response in Rwanda (United States Agency International Development)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• PICOBOO: immunogenicity, reactogenicity and safety of different COVID-19 vaccine (Journal of Infection)
• COVID-19 in previously unvaccinated compared with previously uninfected vaccinated (JID)
• New preventive COVID-19 agent (ISDA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• COVID Data tracker (CDC
• Differences in COVID-19 outpatient antiviral treatment (MMWR)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• COVID-19 is a coronary artery disease with genetic interaction with ABO blood type (AHAIASA Journals)
• COVID-19 doubles risk of heart attack, stroke and death (EurekaAlert!)
• QTL mapping at 7T in COVID-19: brainstem and outcomes (Brain)
• Letters read on TWiV 1156
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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• MicrobeTV Discord Server
• Review confirms mask effectiveness (original article)
• EEE death in Ulster County NY (CBS News)
• EEE on TWiV 1145
• Viruses of farmed fur animals (Nature)
• Tracing of wildlife and viruses at COVID-19 epicenter (Cell)
• Letters read on TWiV 1155
• Timestamps by Jolene. Thanks!

Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions Alan – Birdcast Vincent – A universal framework for inclusive 15-minute cities

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume.

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• Rwanda: Marburg virus disease (WHO)
• Passport required?…..Marburg virus commutes to Germany (CIDRAP)
• Outbreak of whooping cough/pertussis…..no lifelong immunity following vaccination? (Bloomberg
• Protection of infants by maternal antibodies against RSV by either vaccination or nirsevimab (MMWR)
• WHO recommendations for RSV: maternal vaccination and antibody shot (Reuters)
• Ziresovir for RSV hospitalized infants (NEJM)
• Crawling to effective anti-RSV countermeasures (NEJM)
• The $800 million pledge for African mpox response (Reuters)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Doffing your PPE– contact precautions (CID)
• mRNA vaccination does not elicit durable immune response (Nature Medicine)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Mechanisms of long COVID and therapeutics (Cell)
• Post hospitalization cognitive deficits and grey matter reduction 1 year after COVID-19 (Nature Medicine)
• Letters read on TWiV 1154
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections.

Hosts: Vincent Racaniello and Jolene Ramsey

Guests: Krystyna Dabrowska and Rob Lavigne

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• MicrobeTV Discord Server
• Viruses of Microbes 2024
• Immune responses to phages (Front Immunol)
• Engineering bacteriolytic enzymes (Front Immunol)
• 100 cases of phage therapy (Nat Micro)
• Synthetic biology potential of bacteriophages (Nat Micro)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.

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• Waning vaccine protection against mpox…..isn't this the way the humoral immune response works? (CIDRAP) 1:46
• Uncontrollable mpox outbreak in Africa (Reuters) 4:10
• Antibodies elicited by the Jynneos vaccine against mpox contract after 6-9 months….can you believe? (medrxiv) 4:45
• Mpox vaccine for adolescents approved (Pharmaceutical Technology) 14:05
• Clade 1b mpox visiting India (CIDRAP) 15:05
• Mpox clade 1b in Kerala (ANI South Asia's Leading Multimedia News Agency) 15:13
• US government orders $63M worth of small pox/mpox vaccine (Reuters) 15:34
• Mpox donations boosting global supply (US Department of Health and Human Services)
• 1 million mpox vaccine doses for Africa….with love from US government (CIDRAP) 15:55
• Speed doses of mpox vaccine (CIDRAP)
• Mpox vaccine donations (UNICEF) 17:35
• Bavarian Nordic mpox vaccine (Yahoo finances)
• Early epicenter of COVID-19 pandemic Huanan seafood market (Science) 23:07
• Wildlife trade likely source of SARS-CoV-2 (Science) 23:16
• Zoonotic origins of SARS-CoV-2 (Science) 23:20
• Surveillance at the Huanan Seafood market (Europe PMC) 25:03
• TWiV shout outs…..all for the SARS-CoV-2 spill over from nature 25:31
  • TWiV 1019: Eddie Holmes on SARS-CoV-2 origins
  • TWiV 1017: From Nature, not a lab
  • TWiV 995: Viral origin stories
  • TWiV 940: Eddie Holmes in on viral origins
  • TWiV 876: Spillover market with Michael Worobey
  • TWiV 762: SARS-CoV-2 origins with Robert Garry
  • TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
  • TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
• Genetic tracing of market wildlife and viruses at Huanan Market (Cell) 18:56
• Combatting scientific misinformation (microbeTV: TWiV) 34:14
• COVID-19 deaths (CDC) 35:20
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Suggestion for the use of a new preventive COVID-19 agent (IDSA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)
• Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Lower mortality risk associated with remdesivir + dexamethasone versus dexamethasone for hospitalized COVID-19 patients (CID) 39:17
• Changes in memory and cognition during the SARS-CoV-2 human challenge study (eClinical Medicine) 42:25
• Letters read on TWiV 1152 48:18
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly.

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• MicrobeTV Discord Server
• Polio vaccination in Gaza (Reuters)
• Zoonotic viruses in farmed fur animals (Nature)
• HPV vaccination and cancer rates (JAMA Net Open)
• 40 kb RNA genome without error correction (PNAS)
• Stopping the phage tape measure protein (Nat Commun)
• Tail assembly interference (Nat Commun)
• Letters read on TWiV 1151
• Timestamps by Jolene. Thanks!

Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum Vincent – The collapse of bat populations led to more than a thousand infant deaths

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin dives into West Nile virus in New Jersey, poliovirus vaccination campaign in Gaza and Afghanistan, California dengue virus infections, children dying from flu, mpox vaccination procurement and antiviral usage, flu circulation in US, before reviewing the recent statistics on SARS-CoV-2 infection, finding a new wasterwater dashboard, if the monovalent XBB.1.5 COVID-19 vaccine is effective against circulating SARS-CoV-2 isolates, the need for nasal mucosal IgA in response to SARS-CoV-2 infection, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravir treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if those taking the anti-diabetic drug metformin have higher or lower incidences of long COVID.

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• West Nile virus in New Jersey (CBSNews)
• Poliovirus vaccination 90% coverate (Reuters)
• Suspension of poliovirus eradication by the Taliban (apnews)
• California dengue cluster (CIDRAP)
• Children dying of influenza (CIDRAP)
• 199 children deaths from flu (CDC)
• Bavarian Nordic mpox vaccine (Yahoo finances)
• Prequalification of MVA-BN mpox vaccine (WHO Int)
• Speed doses of mpox vaccine (CIDRAP)
• GAVI rapidly secures 500K doses of mpox vaccines for Africa(GAVI)
• Expanded access to teconvirimat for mpox treatment in US 2022-2023(NEJM Evidence)
• FluView (CDC)
• Human to human transmission of bird flu in Missouri? (NY Times)
• Bird flu isolated from humans in Missouri similar to that found in cattle (CNN)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• Waste water scan for 11 pathogens (WastewaterSCan)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccination Against SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 Lineage (CID)
• Early, robust mucosal secretory IgA but not IgG response to SARS-CoV-2 spike in oral fluid is associated with faster viral clearance and COVID-19 symptom resolution (JID)
• Suggestion for the use of a new preventive COVID-19 agent (IDSA)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Lierpool)
• Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)
• Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Metformin use in adults with diabetes and incidence of long COVID (Diabetes Care)
• Letters read on TWiV 1150
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus.

Guest: Mary Estes

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• MicrobeTV Discord Server
• Diarrhea induced by rotavirus NSP4 (Science)
• Minimal infective dose of rotavirus (Arch Virol)
• mRNA release from rotavirus particles (Nat Struct Biol)
• Norovirus vaccine (Clin Ther)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin dives into "pandemic potential" viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones' micriobiota.

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• Lending you the viruses in my fur (Nature)
• mRNA or vaccinia based mpox vaccine (Cell)
• Virtual outpatient management of mpox (OFID)
• NYC: mpox vaccination finder (NYC)
• Vaccine, mpox/COVID-19 near you (NYC)
• Expensive or not expensive anti-RSV monoclonal therapy for infants (American Academy of Pediatrics)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Association of vaccination and SARS-CoV-2 viral load phase 3 (JID)
• IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir outcomes 3 and 6 months after treatment (LANCET Infectious Diseases)
• Antivirals and post-COVID-19 conditions (LANCET Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID following infection with Omicron: oral microbiota changes(American Journal of Medicine)
• Letters read on TWiV 1148
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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• MicrobeTV Discord Server
• Multi-country Mpox outbreak (WHO)
• Face covering ban in Nassau County (NBC)
• Polio case in India (Business Standard)
• More acceptance of vaccine misinformation (EurekAlert)
• War in Gaza not just causing polio (Jerusalem Post)
• Scientist run virus genome database (Science)
• Mpox epidemiology and vaccine effectiveness (Emerg Inf Dis)
• Newborn vulnerability to norovirus diarrhea (Cell Host Microbe)
• Timestamps by Jolene. Thanks!

Brianne – Viral adaptation to climate change Rich – "Understanding the biology of monkeypox virus to prevent future outbreaks" by B. Moss Vincent – We can now watch Grace Hopper's famed 1982 lecture on YouTube

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.

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• Recommendations for seasonal influenza prevention and vaccines (MMWR)
• Gaza: poliovirus RNA in sewage water (Reuters)
• Success of the polio vaccination campaign in Gaza (Reuters)
• UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi)
• mpox vaccine tender (CIDRAP)
• What about vaccines? (Bavarian Nordic)
• Resolving food insecurity (UNICEF USA)
• Semaglutide and the SELECT trial(Journal of the American College of Cardiology)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Optimal duration of systemic corticosteroids treatment (OFID)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Does vaccination prevent long COVID (LANCET: Respiratory Medicine)
• Fibrin drives thromboinflammation & neuropathology in COVID-19(Nature)
• Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)
• Letters read on TWiV 1146
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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• MicrobeTV Discord Server
• Gaza baby has polio (Times Israel)
• Monkeypox virus clade Ib in Thailand (CIDRAP)
• Updated COVID-19 vaccines (FDA)
• Effectiveness of Ebola virus vaccine (Lancet Inf Dis)
• Measles cases in Georgia, Oregon (CIDRAP)
• Retrovirus protein regulates cardiomyocyte development (Cell Stem Cell)
• Receptor shifts govern submergence of encephalitis arbovirus (Nature)
• Letters read on TWiV 1145
• Timestamps by Jolene. Thanks!

Kathy – Googlegangers and AWWW clip Rich – RP FLIP (floating instrument platform) Alan – Big labs are bad for careers Vincent – So You're Underwater: Why Do You See That Circle of Light Above You?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci's case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.

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• Fauci recovering at home from West Nile Virus infection (STAT News)
• Gaza: poliovirus RNA in sewage water (GPEI)
• Bombs and polio…..cease fire, Oh my! (Guardian)
• The variant type 2 poliovirus in Gaza (United Nations: The Question of Palestine)
• 25 years polio free? (Facebook)
• 2 doses of nOPV2= 1.2M vaccines=640,000 children (CNN)
• More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard)
• Sloth fever……Oropouche virus (USA Today)
• Oropouche virus disease import into US (MMWR)
• Gabon's first case of mpox (CIDRAP)
• Declaration of mpox (Gabonese Republic Ministry of Health and Social Affairs)
• What about vaccines? (Bavarian Nordic)
• LC16 replicating smallpox vaccine (WHO)
• Historical smallpox vaccination against mpox clade II (Eurosurveillance)
• FDA approves Emergent Bio's smallpox vaccine for mpox (Reuters)
• Mpox: epidemiology and vaccinology (Emerging Infectious Disease)
• Tecovirimat for MPOX? (STOMP)
• UGH! The WHO has a strategic preparedness and response plan to contain mpox outbreak (WHO)
• WHO preparedness plan prepares to lunch (CIDRAP)
• Working blindly against new mpox isolate (Reuters)
• CDC monkey pox response: TRANSMISSION ? (CDC Newsroom)
• The mpox (Africa CDC: Centers for Disease Control and Prevention)
• Evidence for mpox respiratory transmission(LANCET Microbe)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• SARS-CoV-2 genomes galore (Nextstrain)
• Four free COVID tests! (ASPR: Administration for Strategic Preparedness & Response)
• Great, more SARS-CoV-2 testing! (CIDRAP)
• EUA for updated Novavax COVID-19 vaccine (FDA)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• IDSA suggests new preventive COVID-19 agent (IDSA)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Breakthrough from pemivibart/permgarda (bioRxiv)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Effectiveness of nirmatrelvir/ritonavir preventing hospitalization of high risk patients (Current Therapeutic Research)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• COVID-19, mental illness vaccinated and unvaccinated (JAMA Psychiatry)
• Post acute COVID- 19 outcomes amubarvimab/romlusevimab versus placebo (eClinical Medicine)
• Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)
• Fibrin drives thromboinflammation & neuropathology in COVID-19 (Nature)
• Letters read on TWiV 1144
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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• MicrobeTV Discord Server
• Mpox outbreak is PHEIC (WHO)
• Tecovirimat not great against monkeypox virus clade I (NIH)
• Case of Mpox Clade I in Sweden (PHAS)
• Mpox and pets in USA (Emerg Inf Dis)
• SARS-CoV-2 widespread in wildlife communities (Nat Comm)
• Salivary GAPDH benefits plant virus transmission (Nat Comm)
• Letters read on TWiV 1143
• Timestamps by Jolene. Thanks!

Dickson – NASA Confirms Evidence That Liquid Water Flows on Today's Mars Kathy – TBP for PCR internal control Rich – xmACIS2 compares the data in the ACIS database to that in GHCN-Daily Alan – Larry, the world's most highly cited cat Vincent – The Viral Paleontologist Who Unearths Pathogens' Deep Histories

Ryan – Mpox emergencies AP News one and two Rona – Up in smoke David – Ode to Joy (YouTube, TikTok)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US's aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents.

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• mpox epidemic caused by monkeypox clade I in affected African countries (European Centre for Disease Prevention and Control)
• mpox in Pakistan (Reuters)
• mpox imported into Pakistan (UNMC Global Center for Health Security)
• mpox domesticated in Taiwan (Focus Taiwan: CAN English News)
• clade IIb not Ib in Taiwan (bne Intellinews)
• WHO: mpox public health emergency of global care (NY Times)
• Vaccines didn't turn back mpox…..people did (NY Times)
• Deadlier mpox version in Thailand (NY Times)
• Antiviral tecovirimat….not so much (NIH News)
• What about vaccines? (Bavarian Nordic)
• Invest or not to invest Barvaian Nordic pox vaccine manufacturer? (Yahoo! Finance)
• US to support Africa's mpox response (CIDRAP)
• $35M to support mpox outbreak response in central and eastern Africa (USAID From the AMERICAN PEOPLE)
• COVID-19 deaths (CDC)
• COVID-19 national and regional trends (CDC)
• COVID-19 variant tracker (CDC)
• FDA approves and authorizes updated mRNA COVID-19 vaccines (FDA)
• Novavax still working on updated COVID-19 vaccine (novavax)
• COVID-19 variant update (CDC & IDSA)
• Economic benefit of annual COVID-19 vaccination (JID)
• Early COVID-19 XBB.1.5 vaccine effectiveness (Influenza and other respiratory viruses)
• Uptake of COVID-19 vaccines and associated hospitalization due to COVID-19 in pregnancy (Vaccine)
• Novavax heterologous booster demonstrates lower reactogenicity (JID)
• Where to get pemgarda (Pemgarda)
• EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
• Breakthrough from pemivibart/permgarda (bioRxiv)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What to do when sick with a respiratory virus (CDC)
• When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID differs in children and adolescents (JAMA Network)
• Letters read on TWiV 1142
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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• MicrobeTV Discord Server
• Mpox widespread in Africa (CIDRAP)
• Africa declares Mpox emergency (Science)
• COVID drops to 10th leading cause of US deaths (MMWR)
• Response to detection of poliovirus in Gaza (WHO)
• Molecular mimicry in MIS-C (Nature)
• Neonatal Fc receptor is pan-arterivirus receptor (Nat Comm)
• Antiviral immunity in plants by protein arginine methytransferase 6 (Cell Host Micr)
• Letters read on TWiV 1141
• Timestamps by Jolene. Thanks!

Brianne – Kate Douglass: Olympian and Statistician (Swimming in Data) Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha'Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women's basketball team Rich – Texas State University Forensic Anthropology Research Facility Vincent – Sea lion 'camera crews' capture new footage of ocean floor

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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• Measles transmission after secondary vaccination failure (Emerg Inf Dis)
• Mpox public health emergency of international concern (WHO)
• First case of new mpox strain outside of Africa (Reuters)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Where to get pemgarda (Pemgarda
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• Individual monoclonal antibodies against SARS-CoV-2 should be used (CID)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID science, research and policy (Nature Medicine)
• Measurements of prior SARS-CoV-2 infection and postacute sequelae by the clinical laboratory (Annals of Internal Medicine)
• Risk factors for long COVID syndrome in postmenopausal women with previous SARS-CoV-2 infections (Annals of Epidemiology)
• New studies estimate long-COVID rates, identify risk factors (CIDRAP)
• Monitoring long COVID via telemedicine (PLoS One)
• Letters read on TWiV 1140
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.

Hosts: Vincent Racaniello

Guest: Judith Bruchfeld

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• MicrobeTV Discord Server
• Immune system perturbations in Long COVID (J Immunol)
• Post-COVID immune system perturbations (J Immunol)
• Systems disregulation in Long COVID (Sci Rep)
• Clincal standards for diagnosing, treating, and preventing Long COVID (Intl J Tuberc Lung Dis)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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• Harms of the lab leak hypothesis (Journal of Virology)
• Lab leak mania (PaulOffit, Substack)
• This is a special message: pandemic started in nature! (TWiV)
• RSV vaccine recommendations August 6 2024 (MMWR)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Where to get Pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org) Long COVID defined (NEJM)
• Contribute to our Floating Doctors fundraiser
• Lenacapavir on Puscast #60
• Letters read on TWiV 1138
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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• MicrobeTV Discord Server
• PrEP with HIV-1 capsid inhibitor (NEJM)
• WHO pandemic plan (pdf)
• West Nile virus resurgence in US (NY Times)
• Properties of BANAL SARS-CoV-2 like viruses (Nat Micro)
• BANAL viruses on TWiV 809
• Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med)
• Eng Ong Ooi on TWiV 633
• Letters read on TWiV 1137
• Timestamps by Jolene. Thanks!

Kathy – Using big data to improve traffic light timing Rich – Dillo Dirt Alan – Dueling Banjos on banjo and kora Vincent – The world's most expensive dinosaur and more

Mike – Science through a glass darkly Lisa – On A Mission" Season Four

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.

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• In physicians and hospitals, we trust (JAMA Network)
• Are there benefits for delaying seasonal influenza vaccine selections (JID)
• Personal protective effect for wearing surgical face masks in public spaces (the BMJ)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Cardiovascular safety of different COVID-19 vaccination(Nature Comm)
• Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology)
• Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health)
• Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine)
• The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1136
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

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• MicrobeTV Discord Server
• What's going on with measles? (J Virol)
• Poliovirus in Gaza (Science)
• Sanitation concerns in Gaza (AP)
• Community vaccine beliefs (PLoS One)
• 14 year old dies of Nipah in India (Hindustan Times)
• Selection of nirmatrelvir resistance mutants (Sci Adv)
• CCHFV monoclonal antibodies (Cell Rep)
• CCHFV vaccine (TWiV 565)
• Prometheus Project (TWiV 578)
• TWiV at USAMRIID (TWiV 1015)
• Letters read on TWiV 1135
• Timestamps by Jolene. Thanks!

Angela – Animal research is not always king Brianne – Why the US has more tornadoes than any other country Dickson – Earth's core has slowed so much it's moving backward Alan – Article about the Smithsonian's forensic ornithology lab, led by Carla Dove Vincent – Seventh patient 'cured' of HIV: why scientists are excited

Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses Merck's RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.

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• Clesrovimab, RSV preventative monoclonal antibody for infants (Merck)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine)
• Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine)
• NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID)
• Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID)
• Pemgarda infusion center locator (Pemgarda)
• Respiratory virus guidance (CDC)
• Early phase of SARS-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1134
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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• MicrobeTV Discord Server
• Measles in Brooklyn NY (ABC)
• Measles in Washington DC (DC Health)
• Global childhood immunization stalls (WHO)
• Licensed H5N1 vaccines protect against circulating strains (Nat Med)
• Viruses moving without passports (European CDC)
• OC42-SARS-CoV-2 replacement spike virus (PNAS)
• Deep mutational scanning of Lassa virus glycoprotein (Immunity)
• Letters read on TWiV 1133
• Timestamps by Jolene. Thanks!

Dickson – Elemental sulfur found on Mars Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024 Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?) Alan – Nature sent an investigative reporter to a predatory conference Vincent – Coal-filled trains are likely sending people to the hospital

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr, Daniel Griffin reviews President Biden's case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.

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• President Biden has COVID (CNN, USA Today)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn)
• Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM)
• Pemgarda infusion center locator (Pemgarda)
• Unable to access pemgarda, gotta call Daniel (microbeTV)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Combined treatment of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis)
• Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy)
• Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy (Lancet)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Isolation guidance (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID is defined (National Academies)
• Long COVID: the ANSWERS! (longcovidtheanswers.com)
• The FACTS: post COVID-19=long COVID? (WHO)
• The BASICS of long COVID-19 (CDC)
• Postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras (NEJM)
• Long Covid risk has dropped over time but remains substantial (CNN)
• Efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID (Clin Micro Inf)
• Diet and the gut microbiome: implications for health and disease (Nat Rev Micro)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1132
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

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• MicrobeTV Discord Server
• Articles on Chevron decision (one, two, three)
• Measles in New Hampshire and Vermont (NH DHHS)
• Pathogenicity and transmission of bovine H5N1 virus (Nature)
• Letters read on TWiV 1131
• Timestamps by Jolene. Thanks!

Dickson – Stockholm Wood City Rich – "The Wide Wide Sea" by Hampton Sides Vincent – Tour de France stage 12

Amy – Earth Forced from the Protective Heliosphere: What Do We know?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.