This Week in Virology

In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.

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• H5N1: birds and cows oh, my…..Michigan and Colorado (CIDRAP)
• Flu pandemic for the Colorado chicken (Colorado Sun)
• It's a disaster: Avian flu in Weld county (Colorado.gov)
• More 9.7 million dengue cases in US this year: CDC issues warning (Patch.com)
• Long Island has DENGUE! (Long Island News12)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Association between proton pump inhibitors and COVID-19 susceptibility or severity in children? (Journal of Pediatrics)
• Where to get pemgarda (Pemgarda)
• Unable to access pemgarda, gottacall Daniel (microbeTV)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Benefits of desamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell)
• Anticoagulation guidelines (hematology.org)
• Long COVID: the ANSWERS! (longcovidtheanswers.com)
• The FACTS: post COVID-19=long COVID? (WHO)
• The BASICS of long COVID-19 (CDC)
• Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (CDC)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1130
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics.

Hosts: Vincent Racaniello and Alan Dove

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• MicrobeTV Discord Server
• Measles in Kenya (WHO)
• Intranasal COVID vaccine trial (NIH)
• Dengue in Florida Keys (Florida Health)
• Dengue rising in Central/South America (NPR)
• Spain to connect scientists with government (Science)
• Persistence of T cells and viral RNA after SARS-CoV-2 infection (Sci Transl Med)
• Influenza pandemics induce cross-reactive antibodies against avian N2 (Nat Comm)
• Letters read on TWiV 1129
• Timestamps by Jolene. Thanks!

Alan – The first few minutes of this video by Roger Barnes Vincent – Billy & Molly: An Otter Love Story

Fernando – A City on Mars

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of "pasteurization" before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence.

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• Fourth case human infection associated with an ongoing multistate outbreak of A(H5N1) (CDC)
• Human H5N1 in Colorado and thedefinition of pasteurization (CIDRAP)
• Is "raw" milk more risky than pasteurized (Annenberg Public Policy Center)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Winter, spring, summer and fall COVID-19 surges? (CDC)
• Where to get pemgarda (Pemgarda)
• Unable to access Pemgarda, gotta call Daniel (microbeTV)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Molunpiravir works: reduces hospitalizations and deaths due to COVID-19 and all-cause mortality (CID)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Benefits of dexamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell)
• Anticoagulation guidelines (hematology.org)
• EEG signatures for cognitive decline after SARS-CoV-2 infection (BMC Medicine)
• Tissue resident T-cells and viral RNA 2 years after SARS-CoV-2 infection (Science Translational Medicine)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1128
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses secret anti-vax campaign run by Pentagon to undermine China during pandemic, NY governor's subways mask ban proposal, Colorado bat facility sparks outbreak fears, House budget billls suggest ban on gain of function research, evolution of STAT2 resistance to flavivirus NS5, and brainwide silencing of prion protein by AAV-mediated delivery of an epigenetic editor.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

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• MicrobeTV Discord Server
• Pentagan anti-vac campaign to undermine China (Reuters)
• NY governor subway mask ban (AP News)
• Colorado bat facility sparks outbreak fears (Science)
• House NIH budget bans gain of function research (Science)
• Evolution of STAT2 resistance to flavivirus NS5 (Nat Commun)
• Brainwide silencing of prion protein by AAV delivered epigenetic editor (Science)
• Letters read on TWiV 1127
• Timestamps by Jolene. Thanks!

Dickson – Mars Odyssey Orbiter is about to make its 100,000th orbit Alan – Local animal shelters and "kitten season." Vincent – Supreme Court allows cities to ban homeless people sleeping outside, even when shelter space is lacking

Blog design – Trump vows to defund schools requiring vaccines for students Jon – Detections of highly pathogenic avian influenza in mammals

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.

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• CDC ACIP for RSV (CDC)
• This respiratory virus season everyone age 75 and older receive the RSV vaccine (CDC Newsroom)
• Revised RSV vaccine recommendations (CIDRAP)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Local and systemic response dynamics to SARS-CoV-2 infection (Nature)
• Drink more coffee, reduces risk for SARS-C0V-2 infection (Cell & Bioscience)
• Cannabis, tobacco…smoking in general NOT good for preventing COVID-19 (JAMA Network OPEN)
• Do older versions of the COVID-19 vaccine still provide any protection (JAMA Internal Medicine)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Adjuvant statin therapy reduces SARS-CoV-2 mortality (American Journal of Medicine)
• Nirmatrelvir and ritonavir beyond 5 days of symptom onset improved the multiple organ dysfunction in severe COVID-19 patient (BMC Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Faecal microbtiota transplantation cures sleep disturbance in post-acute COVID-19 syndrome (Clinical Gastroenterology and Hepatology)
• Long COVID defined by patient phenotype (CIDRAP)
• Three distinct symptom-based post-COVID condition phenotypes (JID)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1126
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews criticism of NIAID monkeypox virus experiments by House Republicans, spread of wild poliovirus across Afghanistan and Pakistan, plan to overhaul NIH by House lawmakers, and the potential pandemic risk of circulating swine H1N2 influenza viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli

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• MicrobeTV Discord Server
• 2024 International HBV Meeting
• House Republicans fault NIH for evasive answers on monkeypox virus study (Science)
• Report on MPX experiments at NIAID (pdf)
• Wild poliovirus spreads across Pakistan and Afghanistan (Science)
• Plan to overhaul NIH (Science)
• Reforming NIH (pdf)
• Potential pandemic risk of circulating swine H1N2 influenza viruses (Nat Comm)
• Timestamps by Jolene. Thanks!

Angela – Staring at the Sun — close-up images from space rewrite solar science Brianne – Water frost detected on Mars Volcanos Dickson – Best view yet of the Crab Nebula Vincent – Will Your Tattoo Give You Cancer: Probably Not…but Maybe?

Jessica – Manchurian plague

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person's time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals.

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• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Comparison of methods for sterilizing filtering facepiece respirators (American Journal of Infection Control)
• Booster update already! KP.2 of JN.1-lineage (FDA)
• EUA for pemgarda (FDA)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (ID Society)
• Revisiting monoclonal antibody therapy, sotrovimab for treatment during Omicron BA.2 and BA.5 (Infection)
• What do when your healthcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Hospital nurse staffing variation & COVID-19 (International Journal of Nursing Studies)
• Endothelial dysfunction and persistent inflammation severe post-COVID-19 (BMC Medicine)
• Prevalence and risk for CMV reaction due to COVID-19 pneumonia (PLoS One)
• Variables that impact recovery from acute SARS-CoV-2 infetion (JAMA Network Open)
• Reduced olfactory bulb volume with dysfunction after mild SARS-CoV-2 inction (Scientific Reports)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1124
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to Europic 2024 in Jyväskylä, Finland to speak with Tapani Hovi and Caroline Tapparel about their careers and their research on enteroviruses and elimination of poliomyelitis.

Host: Vincent Racaniello

Guests: Tapani Hovi and Caroline Tapparel

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• Survival of influenza virus on banknotes (Appl Environ Micro)
• Variant EV-A71 in immunosuppressed patient (Cell Rep)
• Rhinoviruses and respiratory enteroviruses (Viruses)
• Isolation of poliovirus in mouse cells producing Pvr (J Clin Micro)
• Outbreak of paralytic poliomyelitis in Finland (Lancet)
• Role of environmental poliovirus surveillance in global polio eradication (Epi Infect)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses expanded use of the RSV vaccine by GSK, how the youngest member of the MicrobeTV family was hospitalized with RSV, why we are seeing more RSV infections than before the pandemic and how administration of monoclonal antibody therapy does not prevent infection but disease, before reviewing the weekly US COVID update, how SARS-CoV-2 affects neurodevelopment of the fetus and probability of preeclampsia, if giving Paxlovid prevents long COVID, and FDA recommends switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations.

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• Young "Immune" co-host with RSV (YouTube)
• RSV on Immune (MicrobeTV)
• More children hospitalized with RSV after pandemic than before (Pediatrics)
• France supports Nirsevimab for RSV (Influenza and other respiratory viruses)
• Protects against disease not infection Nirsevimab (CIDRAP)
• TWiV tells it likes it is: protects against disease NOT infection (TWiV 695)
• RSV vaccine access expanded 50-59 (CIDRAP)
• GSK RSV vaccine expanded use for high risk 50-year olds (GSK)
• COVID-19 deaths
• COVID-19 national trend
• Neurodevelopmental delay in children whose mothers exposed to SARS-CoV-2 (Scientific Reports)
• Preeclampsia associated with SARS-CoV-2 infection (Journal of Maternal-Fetal & Neonatal Medicine)
• Effectiveness of nirmatelvir/ritonavir in children and adolescents (Nat Comm)
• JN.1 for fall COVID-19 boosters (FDA)
• COVID-19 vaccine booster switch (CIDRAP)
• EUA for pemgarda (FDA)
• Infusion centers near you! (pemgarda.com)
• CDC quarantine guidelines (CDC)
• Early phase of SARS-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficiacy (JMV)
• Convalescent plasma recommendations for immunocompromised (ID Society)
• Updated respiratory virus guidelines (CDC)
• What to do when your healthcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staff shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Nirmatrelvir-ritonavir prevents long COVID-19? (JAMA Medicine)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1122
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey

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• MicrobeTV Discord Server
• SARS-CoV-2 origin discussions previously on TWiV:
  • TWiV 1019: Eddie Holmes on SARS-CoV-2 origins
  • TWiV 1017: From Nature, not a lab
  • TWiV 995: Viral origin stories
  • TWiV 940: Eddie Holmes in on viral origins
  • TWiV 876: Spillover market with Michael Worobey
  • TWiV 762: SARS-CoV-2 origins with Robert Garry
  • TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
  • TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
• Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• MicrobeTV Discord Server
• 2024 International HBV Meeting
• Register for ASV Annual Meeting
• SARS-CoV-2 origin discussions previously on TWiV:
  • TWiV 1019: Eddie Holmes on SARS-CoV-2 origins
  • TWiV 1017: From Nature, not a lab
  • TWiV 995: Viral origin stories
  • TWiV 940: Eddie Holmes in on viral origins
  • TWiV 876: Spillover market with Michael Worobey
  • TWiV 762: SARS-CoV-2 origins with Robert Garry
  • TWiV 760: SARS-CoV-2 origins with Peter Daszak, Thea Kølsen Fischer, Marion Koopmans
  • TWiV 774: Kristian Andersen, Robert Garry, and the deleted SARS-CoV-2 sequences
• Why the Pandemic Probably Started in a Lab, in 5 Key Points (NY Times)
• Phage Paride kills dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa (Nat Comm)
• Interview with Enea Maffei (Spotify)
• Timestamps by Jolene. Thanks!

Brianne – How to build a nuclear warning for 10,000 years' time Rich – Doctor My Eyes | Jackson Browne Alan – WHO Health for All Film Festival winners Jolene – El enemigo de mi enemigo es mi amigo Vincent – A Population Dotmap of New York City and Race and Ethnicity in New York City

David – The greatest clock (and map) ever made Peter – The Mouse as a Microscope

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna's mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function.

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• More cattle and dairy workers infected with highly pathogenic H5N1 in Michigan (CDC Newsroom)
• Not eye but respiratory human H5N1 in Michigan (CIDRAP)
• Emory and Stanford'sH5N1 dashboard (Emory and Stanford)
• FDA approval for MRESVIA(FDA)
• Moderna RSV vaccine for the elderly (CIDRAP)
• Moderna announces approval of MRESVIA (moderna)
• FDA VRBPAC meeting for fall COVID boosters (FDA)
• JN.1 variant for fall booster (CIDRAP)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Masks and respirators for source control from viral aerosol shedding (Lancet)
• Spring vaccine advice (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• EUA for pemgarda (FDA)
• Where to get pemgarda (Pemgarda)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (ID Society)
• Drug interaction checker (University of Liverpool)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendations for immunocompromised (IDSociety)
• Updated respiratory virus guidances (CDC)
• What to do when your healthcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Early use of oral antiviral drugs and risk of long COVID (Journal of Infection)
• Early antiviral use associates with low risk of long COVID (CIDRAP)
• Long-COVID autonomic syndrome impairment (Scientific reports)
• Autonomic nervous assessment tool (hATTR)
• Do you know percentage of population with long COVID? (CDC National Center for Health Statistics)
• How many symptoms are there to long COVID? (CIDRAP)
• Long-term health effects of long COVID (National Academies of Sciences Engineering Medicine)
• Long COVID evidence based review TWiV shout out
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1120
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• 2024 International HBV Meeting
• Michelson Prizes: Next Generation Grants
• Register for ASV Annual Meeting
• Monkeypox virus shedding (Nat Commun)
• Gene editing of herpes simplex virus (Nat Commun)
• Letters read on TWiV 1119
• Timestamps by Jolene. Thanks!

Angela – Unconventional Sex Let Anglerfish Conquer the Deep Ocean Kathy – Doonesbury from 5-26-24. And Publish or Perish game Rich – Sky: Giant Sunspot Region 3664 and Resulting Auroras APOD video Vincent – Mysterious sea urchin plague is spreading through the world's oceans

Abdulaziz – Biomedical Scientist Answers Pseudoscience Questions

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID. For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117.

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• Bird dogs infected with high pathogenic avian flu H5N1(AKC)
• Hunting dogs with antibodiesagainst influenza A (H5N1) (Emerging Infectious Diseases)
• Dairy cattle and 2 humans infected with highly pathogenic avian influenza A (H5N1) (MMWR)
• Daisy, are you reading NEJM: cow's milk infected with highly pathogenic avian influenza A (H5N1)? (NEJM)
• Better yet, listen TWiV 1117: pol dances with RNA to learn if mice can transmit H5N1 to each other
• Alpacasinfected with for highly pathogenic avian influenza A (H5N1) (CIDRAP)
• USDA is now inspecting for highly pathogenic avian influenza A (H5N1) in alpacas in Idaho (USDA APHIS)
• COVID-19 deaths
• COVID-19 national trend
• Risk factors for pediatric critical COVID-19 (JPIDS)
• Kids and their underlying conditions for increased risk for severe COVID-19 (CIDRAP)
• SARS-CoV-2 transmission during airline flights (Environmental Research and Public Health)
• Spring vaccine advice(CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practice slides(CDC)
• Really, durable immune response of XBB.1.5 vaccines against Omicron subvariants (NEJM)
• EUA for pemgarda(FDA)
• Infusion centers near you! (pemgarda.com)
• CDC quarantine guidelines (CDC)
• Early phase of SARS-CoV-2 infection (COVID.gov)
• NIHCOVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelinesfor treatment and management (IDSociety)
• Drug interaction checker (University of Liverpool)
• Molnupiravirsafety and efficiacy (JMV)
• Convalescent plasma recommendations for immunocompromised (IDSociety)
• Updated respiratory virus guidelines (CDC)
• What to do when your healthcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staff shortages (CDC)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Post COVID-19 following virus vaccination (Nat Comm)
• Why include long COVID-19 when developing novel treatments for acute disease (JID)
• Cerebral microstructural alterations post COVID-19 cognitive, memory and fatigue (Nat Comm)
• Cognitive impairment prevalence and co-occurrence in children and young adults 12 months after Omicron infection (Brain)
• Persistent static lung hyperinflation and small airway dysfunction in long COVID (Respiratory Research)
• Long COVID evidence based review TWiV shout out
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1118
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV discusses presence of infectious avian H5N1 influenza virus in raw milk from infected dairy cows. dynamics of measles immunity from birth and following vaccination, and a mechanism for cis-preferential reverse transcription revealed by deep mutational scanning of hepatitis B virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• 2024 International HBV Meeting
• Michelson Prizes: Next Generation Grants
• Register for ASV Annual Meeting
• H5N1 influenza virus in raw cow milk infects mice (NIAID News)
• Dynamics of measles virus immunity from birth (Nat Comm)
• Mechanism of cis-preferential HBV reverse transcription (Cell)
• Timestamps by Jolene. Thanks!

Dickson – Oldest virus in Neanderthal bones Brianne – Jeopardy! winner reveals entwined memory systems make a trivia champion Kathy – Bright future of intelligent fabrics primary article and Self-dyeing textiles (primary article) Rich – Farewell to HD Atlas; Boston Dynamics Retires HD Atlas Robot Alan – Why vaccinating cattle against H5N1 is hard Vincent – Singapore Airlines turbulence: why climate change is making flights rougher

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin delves highly pathogenic H5N1 biology including its circulation in New York City, being able to infect cells within mammary glands and why testing is not supported before reviewing the recent statistics on SARS-CoV-2 infection, how vaccination reduced deaths and hospitalizations associated with COVID-19 and how to take off PPE to reduce virus transmission, discussing the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database and the global phase 3 trail of a novel antiviral, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, reminisces about when available monoclonal antibody therapies were effective, and discusses muscle training/exercise for treatment of PASC/long COVID and the use of RNase for its treatment. For more information about long COVID-19 listen to TWiV 1088.

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• Clade 2.3.4.4b of highly pathogenic H5N1 in NYC (J Vi)
• Avian and human influenza A receptors in bovine mammary glands (bioRxiv)
• Where livestock infected with HPAI live (USDA)
• Another dairy worker contracted bird flu (NY Times)
• Reluctance to test for H5N1 (STAT News)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Estimates of hospitalization and deaths prevaccination era (Emerg Inf Dis)
• Slightly less than half of COVID-19 patients died prevaccination (CIDRAP)
• Spring vaccine advice (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• Drug interaction checker (University of Liverpool)
• Global phase 3 study of ensitrelvir (Shionogi)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Remember when monoclonal antibody therapies worked (JID)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Global clinical study of long COVID-19 (International Journal of Infecitous Diseases)
• Cardiopulmonary exercises testing of children with long COVID-19 (Pediatric Infectious Disease Journal)
• Phase 2 trial of RSVL-132 for severe fatigue related to PASC (CID)
• Muscle training may improve diaphragm muscle weakness 2 years after COVID-19 (American Journal of Respiratory Critical Care Health)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1116
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews results of a phase 3 trial of a self-amplifying mRNA COVID-19 vaccine, and the finding that baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology.

Hosts: Dickson Despommier, Alan Dove and Brianne Barker

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• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Michelson Prizes: Next Generation Grants
• Immunogenicity and safety of self-amplifying mRNA COVID-19 vaccine (Lancet Inf Dis)
• First self-amplifying mRNA vaccine approved in Japan (Science)
• Rise of the RNA machines (Trends Biochem)
• Innate and T cell populations correlates of protection against influenza (Nat Immunol)
• Timestamps by Jolene. Thanks!

Dickson - Nitrogen-fixing organelle in a marine algaBrianne – Mapping a lost branch of the Nile Alan – Interactive version of the updated USDA gardening zone map on NPR.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin delves into discussing drinking "raw" milk possessing H5N1 influenza virus, if the virus can reproduce in the human gut, and the meaning of finding viral RNA in wastewater samples before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, withdrawal of AstraZeneca's SARS-CoV-2 vaccine from the European market, discusses the emergency use application of a pre-exposure prophylactic, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of colchicine for the management of COVID-19, compares and provides information for the enrollment into the NIH clinical trials of long COVID and its effects on sleep, exercise intolerance and the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance and post-exertional malaise. For more information about cow and milk infection by H5N1 listen to the discussion with Richard Webby on TWiV 1113 and for long COVID-19 listen to TWiV 1088. Dr. Griffin also provides a list of apps for monitoring one's health including brain health.

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• Who demands milk infected with H5N1? (Futurism)
• Uncowed by milk possessing H5N1 (LA Times)
• Cow flu flying around for 4 months (CNN)
• The unpasteurized raw milk institute (Raw Milk Institute)
• Infection and reproduction of H5N1 in the human gut (JID)
• Wastewater samples identified H5N1 in 9 cities (medrxiv)
• Richard Webby, is H5N1 a concern? (TWiV 1113)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Spring vaccineadvice (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• Withdrawal of Astra-Zeneca SARS-CoV-2 vaccine in Europe (European Medicines Agency)
• Astra-Zeneca withdraws SARS-CoV-2 vaccine from market (AP news)
• Global vaccine data/adverse event network (Vaccine)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• Early phase of SARs-CoV-2 infection (COVID.gov)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• Overuse ofantibiotics for COVID-19: a viral disease (European Society of Clinical Microbiology and Infectious Diseases)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Colchicine for managing COVID-19 (BMC Pulmonary Medicine)
• Colchicine guidelines (ID Society)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• NIH long COVID sleep disturbance, exercise intolerance and post exertional malaise clinical trials (NIH News)
• COVID-19 Yorkshire rehabilitation scale (BML Open Respiratory Research)
• Visible heart monitor (Makevisible)
• Bearable app (Bearable)
• Tracking your chronic illness using Flaredown (Flaredown)
• Improving your brain health (BrainHQ)Vanderbilt's long COVID resources: podcasts and books (Vanderbilt University)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1114
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Richard Webby joins TWiV to review the history of avian H5N1 influenza virus, the recent change in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Richard Webby

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• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Webby research laboratory
• H5N1 virus in dairy cattle and cats (Emerg Inf Dis)
• Emergence of H5N1 virus in dairy cattle (bioRxiv)
• Spillover potential of H9N2 bat virus (Nat Commun and TWiV 1111)
• Letters read on TWiV 1113
• Timestamps by Jolene. Thanks!

Brianne – The Little Researcher (from Bioss) Alan – Global Polio Eradication Initiative's OPV switch was "unqualified failure." Vincent – Errant Science

Moragh – Paper Cuts Podcast

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin deep dives into infections of dairy cattle with high pathogenic influenza H5N1, how long virus has been circulating and if known anti-influenza antivirals can reduce secondary attack rates, before reviewing the recent statistics on SARS-CoV-2 infection, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster takes associates with long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, if administration of oral antiviral therapies can prevent the onset of post-acute sequelae following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, compares and contrasts the cognitive profile in multiple sclerosis and post-COVID, exercise intolerance following SARS-CoV-2 infection and the epidemiology of the pandemic in a Kenyan refugee camp. For more information about this body of work, listen to TWiV 1088.

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• Technical reports on high path avian influenza (CDC)
• High path cow influenza H5N1 clade 2.3.4.4b (Emerging Infectious Diseases)
• Cow flu flying around for 4 months (CNN)
• Interstate commerce: high path avian influenza in dairy cattle (bioRxiv)
• Oseltamivir and baloxavir marboxil treatment for influenza in household index cases (Influenza and other respiratory viruses)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Spring vaccine advice (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• Overuse ofantibiotics for COVID-19: a viral disease (European Soc Clin Micro Inf Dis)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Antiviral effect of metformin on SARS-CoV-2 viral load (CID)
• Nirmatrelvir-ritonavir to prevent post-acute sequelae and mortality in SARS-CoV-2 hospitalized patients (Lancet Infectious Diseases)
• Oral antivirals for acute and post-acute sequelae from SARS-CoV-2 infection (Lancet Infectious Diseases)
• Nirmatrelvir-ritonavir for prevention of COVID-19 related hospitalization (American Journal of Therapeutics)
• Nirmatrelvir-ritonavir effectiveness (American Therapeutics)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Cognitive profile in multiple sclerosis and post-COVID (Scientific reports)
• Exercise intolerance in long COVID (American Journal of Medicine)
• Epidemiology of SARS-CoV-2 in the Kakuma refugee camp, Kenya (Emergining Infectious Diseases)
• Rohingya refugees (USA for UNHCR)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1112
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews viruses in the news: Chinese scientist who released the SARS-CoV-2 genome sequence sleeps in the street, a case of measles in Haifa, spread of waterborne infectious diseases in Gaza, interstate spread of avian influenza A(H5N1) in dairy cattle, and an orangutan heals himself with medicinal plants, followed by identification of a cell receptor for parechoviruses, and blockade of necroptosis prevents lung injury in severe influenza.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

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• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• The New City by Dickson Despommier (blog post)
• International Conference on Pandemic Preparedness
• Chinese virologist sleeps on street (Nature)
• Measles in Haifa (Jerusalem Post)
• Waterborne illness spreads in Gaza (Reuters)
• Interstate spread of H5N1 virus in dairy cattle (bioRxiv)
• Orangutan uses medicinal plants (Science)
• Parechovirus cell receptor identified (Nat Comm)
• Necroptosis blockade prevents lung injury in influenza (Nature)
• Necroptosis, pyroptosis and apoptosis (Cell Mol Immunol)
• Letters read on TWiV 1111
• Timestamps by Jolene. Thanks!

Dickson – NASA's Webb Finds Ethanol, Other Icy Ingredients for Worlds Alan – MyClimate.org calculators Vincent – Twenty-Five Lectures in Virology 2024

Alan – NPR story and interactive quiz on pandemic respiratory disease transmission Az – H5N1 Avian Flu in Mammals

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin begins with discussing if the antibiotic neomycin is really a pan-antiviral countermeasure, then reviews the recent statistics on SARS-CoV-2 infection before deep diving into if shedding and the rapid antigen test results correlate, the guidelines for spring administration of COVID vaccines boosters, whether COVID booster associates with the long COVID prevalence, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, the caveats for improper use of antibiotics to treat SARS-CoV-2 (a viral infection), continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of an anti-immunoglobulin E monoclonal antibody can be used for COVID-19 treatment, if inhibiting T-cell activation will reduce secretion and production of inflammatory cytokines including IL-6, if changes in the gut microbiome associate with post -acute COVID-19 syndrome, and the pulmonary and neurologic determinants of long COVID-19 such as the presence of neurofilament light chain in plasma. For more information about this body of work, listen to TWiV 1088.

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• Intranasal antibiotic evokes antiviral response (PNAS)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• SARS-CoV-2 shedding vs rapid antigen test performance (MMWR)
• Spring vaccineadvice (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• COVID-19 booster take: cross-sectional study (Vaccine)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• Overuse ofantibiotics for COVID-19: a viral disease (European Society of Clinical Microbiology and Infectious Diseases)
• Can you believe that antibiotics are ineffective against a viral illness (NKT Institute)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Immunologic antiviral therapy with omalizumab (OFID)
• Abatacept pharmacokinetics and exposure response (JAMA Network Open)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Gut microbiome and post-acute COVID-19 syndrome, ugh? (Cell Host and Microbe)
• Pulmonary long COVID (JCI Insight)
• Neurofilament light chain in long COVID019 neurocognitive symptoms (Molecular Psychiatry)
• Contribute to our Floating Doctors fundraiser
• Letters read on TWiV 1110
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews avian H5N1 influenza virus in the US, measles at highest levels in England, positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution, and cross-species spill-over potential of the H9N2 bat influenza A virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Alan Dove

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Become a patron of TWiV!

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• The New City by Dickson Despommier (blog post)
• International Conference on Pandemic Preparedness
• Bird flu in humans (NY Times)
• H5N1 genome sequences (USDA)
• Measles cases and outbreaks (CDC)
• Latest measles statistics (UK)
• Positive selection underlies ORF8 loss (Nat Comm)
• Spillover potential of bat H9N2 influenza virus (Nat Comm)
• Letters read on TWiV 1109
• Timestamps by Jolene. Thanks!

Dickson – Journey to the Andromeda Galaxy, Highest jump in human history Alan – What Does a Scientist Look Like? photo gallery by Nature, and public display in London Vincent – The Campus-Left Occupation That Broke Higher Education, I'm a Columbia Professor. The Protests on my Campus are not Justice

David – Blue Angels unbelievable footage

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, and H51 influenza infection of birds, poultry and cows before and SARS-CoV-2 circulation, before discussing if the original monovalent SARS-CoV-2 vaccine was effective in children and adolescents, how to use words to properly describe respiratory pathogens the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic, revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if administration of remdesivir reduces mortality, long COVID, persistence of virus infection during long COVID and it prevalence. For more information about this body of work, listen to TWiV 1088.

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• Measles tracking (CDC)
• Cows, chickens and birds H5N1….oh, my (USDA)
• Evolution of circulating H5N1 (CIDRAP)
• COVID-19 national trend (CDC)
• COVID-19 deaths (CDC)
• Original monovalent mRNA vaccine effectiveness in children and adolescents (MMWR)
• Updated terminology for pathogens transmitted through the air (WHO)
• Are these really better definitions for pathogens transmitted through the air (NY Times)
• Pharmaceuticals for diseases spread through the air (Reuters)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• WHO vs national guidelines for COVID-19 therapeutics (BMJ)
• COVID-19 and the bay of pigs (UNC)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir associated with reduced mortality of hospitalized oxygenated patients (OFID)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Long COVID prevalence among adults (MMWR)
• Persistence of SARS-CoV-2 infection (Lancet Infectious Diseases)
• More questions, new answers long COVID (Lancet Infectious Diseases)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1108
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

It has been a long time since TWiV has released an all listener email episode, and if you have been waiting for one, then this episode is for you! (and everyone else of course).

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• The New City by Dickson Despommier (blog post)
• International Conference on Pandemic Preparedness
• Letters read on TWiV 1107
• Timestamps by Jolene. Thanks!

Brianne – Cats Are Perfect. An Evolutionary Biologist Explains Why Alan – Bardcore music by Hildegard von Blingin' Vincent – A quote from Georgia O'Keefe: "I think it's so foolish for people to want to be happy. Happy is so momentary – you're happy for an instant and then you start thinking again. Interest is the most important thing in life; happiness is temporary, but interest is continuous". From the dailyphilosopher

Julia – Recent success in troubleshooting autoclave challenges Charmaine – Viruses, myelin, the evolution of complex life, and the Fermi paradox

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles, potential risk factors for severe disease following influenza infection before and SARS-CoV-2 circulation, before discussing if SARS-CoV-2 infection impacts sperm fertility, the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC,continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and long COVID. For more information about this body of work, For more information about this body of work, listen to TWiV 1088.

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• Measles tracking (CDC)
• Influenza risk factors for potential severe outcomes (OFID)
• COVID-19 national trend (CDC)
• Does SARS-CoV-2 infection influence sperm quality (Scientific Reports)
• Spring COVID-19 booster recommendations (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices slides (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• Slide 19 (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Infectious Disease Society guidelines for treatment and management (IDSociety)
• Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM)
• Nirmatrelvir/ritonavir vs. remdesivir for treatment of high risk outpatients (Therapeutic Advances in Infectious Disease)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Outpatient treatment with concomitant vaccine-boosted convalescent plasma (mBio)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org) Long COVID evidence based review TWiV shout out (TWiV 1088)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1106
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews influenza H5N1 in North American cows and in birds throughout New York City, polio health emergency extended, ChatGPT to control vaccine hesitancy, increasing viral hepatitis worldwide, dengue public health alert in Puerto Rico, cherry trees drowning in Washington DC, death of iron lung Paul, origin and dispersal history of hepatitis B virus in Eastern Eurasia, and antibody-independent protection against heterologous SARS-CoV-2 challenge.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• The New City by Dickson Despommier (blog post)
• Navigating the U.S. Immigration System webinar
• International Conferene on Pandemic Preparedness
• Avian influenza in dairy cows North Carolina and South Dakota
• H5N1 clade 2.3.4.4 Pathogenic flu throughout NYC
• Polio from Afghanistan to Pakistan extending public health emergency
• CHAT GPT to combat vaccine hesitancy
• Viral hepatitis worldwide
• Dengue public health alert in Puerto Rico
• Cherry trees being drowned by water level rise in DC
• Paul in iron lung dies (NPR)
• Hepatitis B virus in Eastern Eurasia (Nat Comm)
• Antibody-independent protection against heterologous SARS-CoV-2 (Nature)
• Timestamps by Jolene. Thanks!

Brianne – Do Other Planets Have Solar Eclipses? Kathy – Radcliffe Wave and Mt. Etna smoke rings with video Rich – Spongy Oak Apple Gall Wasp (Amphibolips confluenta) Life cycle; Gall formation Alan – Rogue attempt to clone giant sheep for captive hunting Vincent – The Scientists Rock. Literally.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles before addressing results of Pfizer's phase 3 RSV vaccine clinical trial for adults under 60, RSV, influenza and SARS-CoV-2 circulation, differences between rural and urban communities dealing with SARS-CoV-2 infections, the latest statistics on influenza and COVID-19 circulation, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how long COVID affects the brain and associates with an increase in allergic incidents as well as if post SARS-CoV-2 infected patients are unable to exercise or have functional limitations. For more information about this body of work, listen to TWiV 1088.

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Become a patron of TWiV!

• Measles tracking (CDC)
• Measles just this year (MMWR)
• ABRYSVO phase 3 results (Pfizer)
• RSV surveillance (CDC)
• Influenza/flu surveillance (CDC)
• Provisional deaths due to COVID-19 (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Rural-urban differences in COVID-19 mortality and hospitalizations (OFID)
• Spring COVID-19 booster recommendations (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Nirmatrelvir for vaccinated or unvaccinated COVID-19 patients (NEJM)
• Assessment for clinical usefulness (NEJM)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Updated respiratory virus guidances (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Brian and cognitive changes in long COVID patients (BRAIN)
• Allergic disease incidents after COVID-19 (Nat Comm)
• Can post COVID patients exercise or do they have functional limitations (JAMA Network Open)
• Contribute to our ASTMH fundraiser at PWB 37:06
• Letters read on TWiV 1102 37:56
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Vincent travels to the University of Texas in Austin to speak with speak with Jason McLellan about his career and his research on the SARS-CoV-2 spike protein, including the effect of adding two proline residues, its effect on other viral spike glycoproteins, and general approaches to vaccine design.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jason McLellan

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier
• Prefusion-stabilized SARS-CoV-2 spikes (Science)
• Structure-based vaccine design (Curr Opin Immunol)
• Prefusion-stabilized SARS-CoV-2 S2-only antigen (Nat Comm)
• Stabilized coronavirus spike stem elicits broadly protective antibody (Cell Rep)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles and influenza before addressing Vincent's comment on measles inclusion in the clinical respiratory PCR panel, the latest statistics on influenza and COVID-19 circulation, if inflammatory cytokines and anti-viral antibody function synergistically, if administration of peptide agonists of the glucagon-like or sodium-glucose pump can reduce disease severity, restates the guidelines for spring administration of COVID vaccines boosters, discusses the emergency use application of a pre-exposure prophylactic. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound, revised guidelines for SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir or paxlovid can reduce cardiovascular adverse events and the first finding of the two-year longitudinal study on long COVID. For more information about this body of work, listen to TWiV 1088.

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• Measles tracking (CDC)
• What happens when measles is included in commercial syndromic PCR panels (MMWR)
• Influenza/flu surveillance (CDC)
• Influenza on the Texas ranch (Statnews)
• Sequence analysis of highly pathogenic avian influenza from Texas (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Can inflammatory cytokines and antibodies play nicely to prevent COVID-19 mortality (IJID)
• Association of GLP-1RA and SGLT-2i to modulate COVID-19 severity (Diabetes Therapy)
• Spring COVID-19 booster recommendations (CIDRAP)
• Older adult spring booster available (CDC)
• Advisory committee for immunization practices spring 2024 COVID-19 boosters (CDC)
• EUA for pemgarda (FDA)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Remdesivir and cardiac adverse events in hospitalized patients (CID)
• Long COVID evidence based review TWiV shout out (TWiV 1088)
• Longitudinal study reveals long COVID symptom peaks and nadirs (OFID)
• Paxlovid lowers risk of cardiovascular disease in COVID-19 patients with autoimmune disease (BMC Medicine)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1102
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Paul Offit joins TWiV to discuss his latest book, "Tell Me When It's Over", an insider's guide to deciphering COVID myths and navigating our post-pandemic world.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Paul Offit

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier
• Tell Me When It's Over by Paul Offit
• Navigating the U.S. Immigration System (webinar)
• Classifying Viral Subspecies (Workshop)
• Options XII for the Control of Influenza (Meeting)
• Letters read on TWiV 1101
• Timestamps by Jolene. Thanks!

Dickson – Astronomers Unveil Strong Magnetic Fields Spiraling at the Edge of Milky Way's Central Black Hole Brianne – Inside the AI Competition That Decoded an Ancient Herculaneum Scroll Vincent – biotech.symposium on Instagram

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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of measles influenza and SARS-CoV-2, before discussing the development of new monoclonal antibody therapy, if vaccines and antivial drugs can used effectively together. revised guidelines for how to treat respiratory viral infection guidelines by the CDC, continues to dispel the myth of viral rebound including that after administration of the "oral remdesivir", revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if one can predict the loss infectivity of healthcare workers with mild COVID-19 disease and the dynamics of household transmission of the virus in children.

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• Measles tracking (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• What new monoclonal antibody therapy? (FDA)
• A New pre-exposure prophylaxis for COVID-19? (Invivyd)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Really COVID-19 rebound after Nirmatrelvir-ritonavir treatment? (JAMA Network Open)
• Can vaccines and antiviral be effective for COVID-19 together (International Journal of Infectious Diseases)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Can loss of infectivity among healthcare works with mild and recurrent COVID-19 be predicted (CID)
• Household transmission dynamics in children with asymptomatic infection (CID)
• Steroids,dexamethasone at the right time (OFID)Anticoagulation guidelines (hematology.org)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1098
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Vincent travels to the University of Heidelberg to speak with Volker Lohmann about his career and the research of his laboratory on hepatitis C virus, hepatitis A virus, and norovirus.

Host: Vincent Racaniello

Guests: Volker Lohmann

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier
• HCV human challenge studies (Lancet Gastro Hepatol)
• Comparison of HCV and HAV infections (J Hepatol)
• HCV cell culture systems (J Med Chem)

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In his weekly clinical update, Dr. Griffin deep dives into recent domestic and global measles and mpox outbreaks, before reviewing recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2, discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, how much oxygen is necessary for effective treatment of severe disease, how COVID-19 effects the cardiovascular system of children and adolescents with long COVID and how iron metabolism may be altered during long COVID.

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• Measles tracking (CDC)
• Measles in Cook County (MMWR)
• Gaps in measles vaccination drives viral surges (Infectious Disease Advisor)
• Misinformation impacts public health? Seriously? (ID Society)
• CDC alert for global and domestic measles cases and outbreaks (CDC)
• Mpox in Kamituga associated with outbreak in DRB (Eurosurviellance)
• Mpox in US, 2023 (MMWR)
• Mpox in DRC, 2024 (reliefweb)
• CDC guidance for respiratory diseases, COVID antiviral & emergence of clade I mpox (ID Society)
• ~5% of infected dead from mpox (CIDRAP)
• First cases of mpox in Republic of Congo (AP News)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Multisystem inflammatory syndrome in children 2023 (MMWR)
• Guidance for COVID-19 in children and adolescents (JPIDS)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Molnupiravir safety and efficacy (JMV)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• High/low oxygenation target (JAMA)
• How much oxygen is needed (JAMA)
• Orthostatic intolerance in long COVID and healthy volunteers (JMV)
• Autonomic cardiac function in children and adolescents with long COVID (European Journal of Pediatrics)
• Long COVID iron dysregulation and inflammatory stress erythropoiesis (Nat Imm)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1098
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Vincent travels to the fifth Giant Virus Meeting in Tegernsee, Germany and speaks with Sheree Yau and Victoria Queiroz about their research on picoeukaryotes (tiny algal cells) and their viruses, pithoviruses, and an educational kit for virology classes.

Host: Vincent Racaniello

Guests: Sheree Yau and Victoria Queiroz

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• MicrobeTV Discord Server
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• The New City by Dickson Despommier 8:16
• Virophage control of antarctic algal host-virus dynamics (PNAS)
• Timestamps by Jolene. Thanks!
• Virus-host coexistence in phytoplankton through the genomic lens (Sci Adv)
• Two groups of pithoviruses (J Virol)
• Educational toolkit for virology classes (J Virol)

Intro music is by Ronald Jenkees

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In his weekly clinical update, Dr. Griffin highlights measles outbreaks throughout the continental US, reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing if vaccination protected children from the development of long COVID or cardiovascular diseases associated with virus infection, revised guidelines SARS-CoV-2 treatment and how to treat respiratory viral infections, continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, how COVID-19 effects the autonomic nervous system, and if nirmatrelvir-ritonavir protects against adverse cardiovascular effects following SARS-CoV-2 infection.

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• Measles everywhere (CDC)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Estimating niresevimab effectiveness for infants (MMWR)
• More than 100 children died of influenza (NBS News)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Did the vaccine protect children against Long COVID (Pediatrics)
• Did COVID-19 vaccination impact cardiovascular diseases? (Nat Comm)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Updated respiratory infection guidelines (CDC)
• What do when your heathcare provider is infected with SARS-CoV-2 (CDC)
• Managing healthcare staffing shortages (CDC)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID trial for autonomic nervous system dysfunction (NIH)
• Nirmatrelvir-ritonavir impact on myocardial injury and long-term cardiovascular outcomes in COVID-19 hospitalized patients (Cardiovascular Drugs and Therapy)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1096
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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TWiV reviews heterosexual transmission of clade I Mpox virus, continued circulation of oropouche virus in South America, herpesviruses in South American fur seals and sea lions, sex-specific differences in physiological responses to SARS-CoV-2 infection, underdetected dispersal and extensive local transmission drove the 2022 mpox epidemic, and a humanized mouse model for adenovirus-associated virus gene therapy.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Angela Mingarelli

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• MicrobeTV Discord Server
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• Become a member of ASV (asv.org)
• The New City by Dickson Despommier
• Heterosexual transmission of clade I Mpox virus (Emerg Inf Dis)
• Continued circulation of oropouche virus (PAHO and WHO)
• Herpesviruses in fur seals and sea lions (PLoS One)
• Sex-specific effects of SARS-CoV-2 infection (PLoS One)
• Drivers of 2022 Mpox virus epidemic (Cell)
• How AAV gene transfer works (YouTube)
• Humanized mouse model for AAV gene therapy (Nat Comm)
• Timestamps by Jolene. Thanks!

Dickson – Baden Powell – Manha de Carneval Angela – Upcoming Health & Fitness podcast from MicrobeTV Rich – Mark Smith Photography Alan – OpenVertebrate (and Science article on it) Vincent – Veterinary apparel for the veterinary nerd

Anne – Why Reed Jobs is betting on cancer innovations

Intro music is by Ronald Jenkees

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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing revised guidelines for how to treat respiratory viral infection guidelines by the CDC, effectiveness of the new SARS-CoV-2 vaccines and the combination of vaccination and antiviral therapy against the development of disease, continues to dispel the myth of viral rebound, how to pay for paxlovid, the lack of evidence supporting ivermectin as an antiviral drug, when to use steroids and the benefits of convalescent plasma, how COVID-19 affects cognitive function and the effect of long COVID and how healthcare works have difficulty making the proper diagnosis for long COVID even using a questionnaire.

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• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• What to do when you are sick with a respiratory virus (CDC)
• Basis for respiratory virus guidance (CDC)
• Effectiveness of updated COVID-19 vaccines (MMWR)
• CDC Quarantine guidelines (CDC)
• NIH COVID-19 treatment guidelines (NIH)
• Synergy or additive protection with vaccination and oral antivirals (CID)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Still talking about Ivermectin? (Journal of Infection)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Cognition and memory after COVID-19 (NEJM)
• Loss of IQ after SARS-CoV-2 infection (CIDRAP)
• Really, more evidence for long COVID and impaired cognition (NEJM)
• Memory assessment before and after COVID-19 (NEJM)
• Please complete this memory questionnaire (Community hyperbaric)
• Impact of long-term COVID-19 on workers in healthcare settings (PLoS One)
• Healthcare workers have difficulty assessing long COVID (CIDRAP)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1094
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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TWiV discusses effectiveness of this season's flu vaccine, efficacy of Pfizer RSV vaccine, nOPV2 in the US, dengue in Peru, measles in Michigan and Indiana, how coordinated inflammatory responses dictate control of Marburg virus by reservoir bats, and tRNA acquisition in phages driven by degradation of host translational machinery.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, Brianne Barker, and Jolene Ramsey

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• MicrobeTV Discord Server
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• Become a member of ASV (asv.org)
• The New City by Dickson Despommier
• Effectiveness of flu vaccine (MMWR, Eurosurveill)
• Efficacy of Pfizer RSV vaccine (Pfizer)
• Understanding six types of vaccine technologies (Pfizer)
• nOPV in US? (CDC)
• Dengue in Peru (Peruvian State)
• Measles in Michigan and Indiana
• Marburg virus control by reservoir bats (Nat Commun)
• tRNA acquisition by phages (Cell)
• Viruses of Microbes 2024
• Timestamps by Jolene. Thanks!

Brianne – The reappearance of Lake Manly Kathy – "Practical Playbook for Addressing Health Misinformation" Rich – Making It So: A Memoir by Patrick Stewart Jolene – Thinking Like a Phage by Merry Youle Vincent – The Science of Leap Year

Blog design – Anthony Fauci will reflect on his long government career in 'On Call,' to be published in June Peter – Republican warns of vaccines being slipped into vegetables: 'A polio vaccine in there'

Intro music is by Ronald Jenkees

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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus, influenza and SARS-CoV-2 before discussing new vaccine guidelines released by the advisory committee on immunization practices, and reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, the role of IFN-g in long COVID, if the brain-blood-barrier is compromised in long COVID, meaning of persistent community SARS-CoV-2 RNA findings, and the effects of hyperbaric oxygen on post COVID neurocognition.

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• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• RSV vaccination stats (CIDRAP)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• ACIP COVID vaccination for seniors recommendations (CIDRAP)
• Additional vaccine doses for older adults (CDC)
• Evidence based advice from the ACIP (CDC)
• State mandates did NOT influence primary vaccination rates only boosters (PNAS)
• No nOPV2? (CDC)
• CDC Quarantine guidelines (CDC)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Molunpiravir plus antibody therapy for at-risk outpatients (Nat Comm)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Spontaneous release of IFN-g in Long COVID (Science Advances)
• Blood-brain-barrier compromise in long COVID associated cognitive impairment (Nat Neuroscience)
• Persistent community SARS-CoV-2 RNA (Nature)
• Hyberbaric oxygen therapy improves post COVID neurocognition (Scientific Reports)
• Medical study questionnaire, the SHORT form (Brandeis)
• Long term effects of hyperbaric oxygen post COVID (Scientific Reports)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1092
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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TWiV reviews resurgence of Lassa fever in West Africa, at least 3 paralytic cases of cVDPV2 in Zimbabwe, CWD from eating prion-laden plants, measles in New Orleans and Broward County Florida, failure of Florida Surgeon General to support vaccination, a measles variant in Switzerland, SARS-CoV-2 persistent infections, leaky blood-brain-barrier for long COVID brain fog, West Nile virus transmitted among mosquitoes by the excreta, and viroid-like colonists of human microbiomes.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit and Kathy Spindler

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• MicrobeTV Discord Server
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• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Viruses of Microbes 2024
• Resurgence of Lassa fever (Science)
• cVDPV2 in Zimbabwe (UNICEF)
• CWD from eating plants (CIDRAP)
• Measles in New Orleans (LA Dept Health)
• SARS-CoV-2 persistent infections (Nature)
• Leaky BBB for brain fog of long COVID (Nat Neurosci)
• Measles in Broward County FL (7 News)
• Failure of FL Surgeon General to support vaccination (X)
• Measles variant (Eurosurveillance)
• West Nile virus transmitted among mosquitos by excreta (bioRxiv)
• Mosquito life cycle (YouTube)
• Viroid-like colonists of human microbiomes (bioRxiv)
• Letters read on TWiV 1091
• Timestamps by Jolene. Thanks!

Dickson – Sustainable energy in America 2024 factbook Kathy – Life Magnified USPS stamps Rich – "How plants communicate with each other when in danger" by Kasha Patel (Original Nature Communications article) Alan – A Sargasso Sea of Space card game. Vincent – Tell Me When It's Over by Paul Offit

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In his weekly clinical update, Dr. Griffin reviews recent statistics on the circulation of respiratory syncytial virus before discussing uptake of the RSV vaccine Abrysvo or the monoclonal anti-RSV antibody nirsevimab to prevent severe disease following RSV infection in infants 8 months or younger before going over this week's influenza virus and SARS-CoV-2 virus statistics, including all circulating variants in the US, examines if self-testing is more accurate than clinician administered Binax rapid diagnostic tests for SARS-CoV-2 infection, if N95 masks need a yearly fitting, how SARS-CoV-2 vaccination impacts the prevalence of long COVID, reviews the CDC guidelines for quarantine/ isolation following SARS-CoV-2 infection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, why determining the exact number of long COVID incidences is challenging, how the incidence and predictors for fatiguing illness following SARS-CoV-2 infection may used to reenforce the need for public health actions to prevent virus infection and the risks of respiratory pathologies including lung cancer associate with SARS-C0V-2 infection.

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• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• RSV vaccination stats (CIDRAP)
• Abrysvo vaccine stats (Axios)
• RSV vaccination dashboard (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Who is more accurate the clinician or the self for BinaxNow rapid testing (ASM Spectrum)
• Annual N95 fitting (Infection Control and Hospital Epidemiology)
• How vaccination impacts long COVID prevalence (Annals of Epidemiology)
• CDC Quarantine guidelines (CDC)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Long COVID in adults (MMWR)
• Estimating and predicting fatiguing illness after SARS-CoV-2 infection (EIS)
• Long term risks of respiratory disease following SARS-CoV-2 infection (eClinical Medicine)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1080
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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TWiV reviews a fatal Alaskapox case, MERS in Kenya, diagnostic tests for Nipah and Lassa diseases, HPV vaccination rates in the US, cases of measles in Arizona and Minnesota, hepatitis C virus-derived RNA circles in infected cells, and prevention of respiratory virus transmission by resident memory CD8+ T cells.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Brianne Barker

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Become a patron of TWiV!

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Viruses of Microbes 2024
• Fatal case of Alaskapox (AK Beacon)
• MERS in Kenya (Emerg Inf Dis)
• Diagnostic tests for Nipah and Lassa (CEPI)
• Measles in Arizona and Minnesota
• HCV-derived circular RNAs (PNAS)
• Resident memory CD8 T cells prevent respiratory virus transmission (Nature)
• Letters read on TWiV 1089 1:24:33
• Timestamps by Jolene. Thanks!

Dickson – Visualizing Science: Illustration and Beyond Brianne – Vaccination from the Misinformation Virus and Invisible Corps Alan – Preventing needlephobia in kids Vincent – Two new Djs I discovered Rosana Nun and Sunset Cartel

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In his weekly clinical update, Dr. Griffin discusses the use of monoclonal antibody therapy to prevent RSV hospitalization of infants and use of GSK's RSV vaccine Arexy to prevent severe disease following RSV infection in adults between 50-59 years before he reviews recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if how the influenza vaccine is manufactured can reprogram the antibody response, cardiovascular consequences of influenza infection, mortality of chikungunya virus infection, if an alternative vaccination schedule impacts the anti-SARS-CoV-2 immune response, dispels the myth that increased mortality correlated with the first vaccine dose, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how manage long COVID including prevent burnout and compassion fatigue of caring for long COVID patients, whether the CDC or WHO definition of long COVID is beneficial or the use of directed questions, baselines test and listening to the patient tell their story are beneficial in making a long COVID diagnosis.

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• Nirsevimab immunoprophylaxis to prevent RSV hospitalization (Eurosurveillance.)
• Arexvy given Priority Review in US for the prevention of RSV disease in adults aged 50-59 (GSK)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Can antibodies be redirected from egg adapted epitopes using recombinant or cell cultured based influenza vaccines (Nat)
• Can influenza infection lead to cardiovascular events (JID)
• Risk of death after chikungunya infection and disease (Lancet)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Alternative intervals between vaccine doses (Nat Comm)
• Early mortality after first vaccination dose (CID)
• CDC Quarantine guidelines (CDC)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids, dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Burnout compassion fatigue Long COVID (OFID)
• Scoring PASC (JAMA)
• What is your definition of the Long COVID (WHO)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1088
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews rhinovirus complications in infants, a new influenza antiviral drug, Oropouche fever in Brazil, measles in Maryland and Ohio, effect of eliminating non-medical vaccine exemptions in NY, foot-and-mouth disease in Europe, severe primary and secondary dengue infections, and therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Angela Mingarelli

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Become a patron of TWiV!

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Viruses of Microbes 2024
• Infant rhinovirus bronchiolitis contribution to hospital bed and vent use (JAMA Net Open)
• Onradivir new influenza antiviral (Lancet)
• Oropouche fever in Brazil (PAHO)
• Maryland and Ohio measles
• Repealing school vaccination exemptions (JAMA New Open)
• Increases risk of FMDV entry into Europe (pig333)
• Severe primary and secondary dengue (Nat Med)
• Mitigation of measles immune amnesia and exacerbated disease (Nat Comm)
• Letters read on TWiV 1087
• Timestamps by Jolene. Thanks!

Dickson – For Your Processing Pleasure: The Sharpest Pictures of Jupiter's Volcanic Moon Io in a Generation Angela – Whale Scientists Rich – Benefit-risk assessment of vaccines; The Brighton collaboration standardized module for vaccine benefit-risk assessment; Vaccine adverse events: causal or coincidental?; Austin area Singing Valentines Vincent – International Day of Women and Girls in Science, 11 February

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market and why people conceal their infectious diseases before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses if susceptibility and disease severity are inheritable traits, if vaccination during pregnancy protects neonates or leads to adverse effects, the effectiveness of a monovalent XBB.1.5 against disease resulting from infection with Omicron variants, whether vaccination in the same or opposite arms effect antibody protection, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how SARS-CoV-2 infection may alter one's sleep patterns, what the health and economic burdens of mild disease are, and if there are predictors for recovery from fatigue and cognitive deficits following SARS-CoV-2 infection.

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Become a patron of TWiV!

• Do you want a job in healthcare? (JAMA)
• Why people don't tell the truth about infectious diseases (Psychological Science)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Is susceptibility and severity of COVID-19 inheritabile (Nat Comm)
• Neonates of vaccinated mothers (JAMA)
• How is the monovalent XBB.1.5 vaccine effectiveness against symptomatic infection Sept 2023-Jan 2024 (MMWR)
• Second dose in the opposite arm improves antibody response (JCI)
• Virus specific immune repsonses following contralateral or ipsilateral immunication (eBioMedicine)
• CDC Quarantine guidelines (CDC)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• How COVID-19 affected your sleep (Frontiers in Public Health)
• Health and economic burden of COVID-19 after illness (BMC Medicine)
• Predicting recovery from fatigue and cognitive deficits after COVID-19 (eClinical Medicine)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1086
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Viruses of Microbes 2024
• Pig virus imperils food security in Borneo (Science)
• Measles outbreaks in UK and Europe (Nature)
• Fatal Nipah virus infections in Bangladesh (CIDRAP)
• Yellow fever outbreak in Sudan (Crisis24)
• COVID-19 influenced by type of immunodeficiency (Sci Transl Med)
• Intestinal microbiota programming of alveolar macrophages (Cell Host Microbe)
• Letters read on TWiV 1085
• Timestamps by Jolene. Thanks!

Dickson – JWST details of 19 spiral galactic centers Rich – Great White Shark Attack And Breach Vincent – Black History Month and Lost Photographs of Black America

Louise – The Mystery Of The Village That Beat The Black Death Pierre – Three things airlines don't want you to know Brandon – Professor Dave explains

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin discusses the how the pandemic influenced the healthcare job market before he reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, discusses the safety of the prefusion RSV vaccine, if high or moderate dose of the quadrivalent influenza vaccine is better for protection against hospitalization, summarizes the new WHO COVID guidelines, revisits how to prevent pathogen transmission in healthcare setting, the under use of COVID oral antiviral and what occurs in persistently SARS-CoV-2 infected cells in culture after antiviral treatment, continues to dispel the myth of viral rebound, how to pay for paxlovid, when to use steroids and the benefits of convalescent plasma, how inflammatory markers change correlate with death when in ICU and if cognitive slowing is part of long COVID-19.

Become a patron of TWiV!

• Do you want a job in healthcare? (JAMA)
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Efficacy and safety of RSV vaccine after 2 seasons (CID)
• High vs moderate dose of quadrivalent influenza vaccine (CMI)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• WHO COVID guidance (WHO)
• Thoughts on COVID guidance (CIDRAP)
• Update on how to prevent pathogen transmission in healthcare settings (CDC)
• Underuse of antiviral drugs against COVID-19 (MMWR)
• Revisiting tissue culture cells persistently infected following antiviral therapy (bioRxiv)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Changes in inflammatory markers and death correlation when in ICU (Cytokine)
• Long COVID & cognitive slowing? (eClinicalMedicine)
• Contribute to our ASTMH fundraiser at PWB
• Letters read on TWiV 1084
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV reviews global measles outbreaks, toilet-generated aerosols that spread viruses, highly effective prevention of invasive cervical cancer by HPV vaccination, and design of improved adenovirus-associated viral vectors using machine learning.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Jay Nelson obituary
• Measles outbreak in Europe and Central Asia (UNICEF)
• Closing the toilet lid doesn't reduce virus aerosols (Am J Inf Control)
• NASA's ingenuity helicopter mission ends (NASA)
• HPV vaccine prevents invasive cervical cancer (J NCI)
• Designing AAV vectors with machine learning (Sci Adv)
• Letters read on TWiV 1083
• Timestamps by Jolene. Thanks!

Dickson – Asian girl building a life building a fence to protect a bamboo house Rich – Gator Country: Deception, Danger, and Alligators in the Everglades by Rebecca Renner Alan – Strange Bedfellows, by Ina Park Vincent – Star and Sphere kit – try the main page too

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In his weekly clinical update, Dr. Griffin reviews most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus, including all circulating variants in the US, before discussing viral transmission to adults in healthcare setting, the recently EUA approved protein based COBREVAX vaccine, reviews quarantine guidelines, the use of simnotrelivr for mild to moderate COVID-19, how viral RNA may persist in your cell culture dish following antiviral therapy, continues to dispel the myth of viral rebound, how to pay for Paxlovid, , when to use steroids and the benefits of convalescent plasma, how Paxlovid may prevent long COVID and how complement dysfunction may lead to thromboinflammation during long COVID.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

• Articles and graphs cited in TWIV CU 1080
• Respiratory disease surveillance (CDC)
• RSV surveillance (CDC)
• RSV national trend (CDC)
• Influenza/flu surveillance (CDC)
• Influenza/flu map (CDC)
• COVID-19 hospital admissions (CDC)
• COVID-19 national trend (CDC)
• COVID-19 wastewater testing (biobot)
• Variant tracker (CDC)
• Variant hospital admissions (CDC)
• Transmission in healthcare setting (CID)
• COBREVAX EUA (Texas Children's Hospital)
• Quarantine/isolation guidelines (CDC)
• Simnotrelvir for mild to moderate disease in adults (NEJM)
• Are your tissue culture cells persistently infected following antiviral therapy (bioRxiv)
• Structural biology of antivirals for SARS-CoV-2 (Signal Tranduction and Targeted Therapy)
• To rebound or to not rebound (MMWR)
• Know your COVID-19 tools (ESMED)
• How to pay for Paxlovid (PAXCESS)
• Remdesivir for immunocompromised during variant waves (CID)
• Molnupiravir safety and efficacy (JMV)
• Convalescent plasma recommendation for immunocompromised (IDSociety)
• Steroids,dexamethasone at the right time (OFID)
• Anticoagulation guidelines (hematology.org)
• Patients, experts, Congress…..long COVID oh my! (CIDRAP)
• Does paxlovid prevent long COVID? (CIDRAP) Persistent complement with thromboinflammation in long COVID (Science)
• Contribute to our MicrobeTV fundraiser at PWB
• Letters read on TWiV 1082
• Dr. Griffin's COVID treatment summary (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv