This Week in Virology

Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Ralph Baric

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• Mouse-adapted SARS-CoV-2 model (bioRxiv)
• SARS-CoV-2 mRNA vaccine (bioRxiv)
• ASM resources for #shutdownstem
• President Obama on sustaining momentum for change (Facebook)
• America After the Civil War (PBS)
• Image credit
• Letters read on TWiV 626
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.

Hosts: Vincent Racaniello and Rich Condit

Guest: Frederick A. Murphy

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Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin, Chuck Knirsch, and Sabra Klein

Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!

Links for this episode

• SeXX matters in infectious disease pathogenesis (PLoS Path)
• Sex and gender impact immune responses to vaccines (Physiol)
• Testosterone and disease severity in mice (Cell Immunol)
• Age-associated effects on impact of sex steroids on vaccine responses (NPJ Vaccines)
• Evolution of greater humoral immunity in females (Curr Opin Physiol)
• Impact of sex and gender on COVID-19 (Biol Sex Diff)
• COVID-19 trials should include sex as variable (J Clin Inves)
• Global Health 50/50
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Guest: Peter Daszak

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Links for this episode

• Bats are reservoirs of SARSr-CoV (Science)
• Bat SARSr-CoV that binds ACE2 (Nature)
• Rich gene pool of bat SARSr-CoV (PLoS Path)
• Bat SARSr-CoV infect humans (Virol Sin)
• Transmission of bat SARSr-CoV in China (bioRxiv)
• Global Virome Project (Science)
• ASV Virtual Workshops 2020
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Emmie de Wit

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Links for this episode

• Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature)
• Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv)
• Remdesivir for MERS-CoV infection in macaques (PNAS)
• ChAdOX1 vaccination for SARS-CoV-2 in macaques (bioRxiv)
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email.

Hosts: Vincent Racaniello,Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guests: Daniel Griffin and Chuck Knirsch

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• Safety of Ad5 vectored COVID-19 vaccine (Lancet)
• Analysis of hydroxychloroquine use (Lancet)
• Remdesivir study (NEJM)
• Ancient COVID-19 history (MMWR)
• Drug repurposing for COVID-19 (bioRxiv)
• Why do few COVID-19 patients infect others? (Science)
• Overdispersion in COVID-19 transmission (Wellcome Open Res)
• Reducing airborne transmission (Science)
• Letters read on TWiV 621
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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• T cell targets in COVID-19 patients (Cell)
• SARS-CoV-2 seroconversion in humans (Nat Med)
• Convergent antibody responses to SARS-CoV-2 infection (bioRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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• Rabadan Laboratory
• Understanding Coronavirus (Amazon)
• Topological Data Analysis for Genomics and Evolution (Amazon)
• Recombination and mutation shaped SARS-CoV-2 (bioRxiv)
• Bat CoV with cleavage site insertion (Curr Biol)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Intro music is by Ronald Jenkees.

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Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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• Playing tennis safely (USTA)
• Scientists denounce end to CoV grant (NY Times)
• ASMBMB denounces end to CoV grant (pdf)
• For TETRIS, turn to Paterson NJ (NY Times)
• NJ Dept of Health (image credit)
• Differential effects of intervention timing (medRxiv and NY Times)
• Texas to stop combining test results (Statesman)
• How could CDC make that mistake? (Atlantic)
• The Pandemic and Information Network (Columbia Journ Rev)
• Helmet and tent (Science)
• New song, old melody (Cell Host Microbe)
• Letters read on TWiV 617
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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• Drowning in COVID-19 papers (Science)
• CORD-19
• 2019 NCRC
• AI powered literature review
• SciSight
• Graphical guide to CoV vaccines (Nature)
• Moderna Phase I results
• Liposomes and lipid nanoparticles (Exelead)
• Cigarette smoke increases ACE2 (Dev Cell)
• Letters read on TWiV 616
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease.

Hosts: Vincent Racaniello

Guests: Peter Daszak

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Intro music is by Ronald Jenkees.

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Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Daniel Griffin

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• Triple therapy for COVID-19 (Lancet)
• Virology podcast goes viral (Thalia Gigerenzer)
• Paul Stays Home (pdf)
• Multibasic cleavage site essential for SARS-CoV-2 infection (Mol Cell)
• Mumbai engulfed by CoV (NY Times)
• All must be vaccinated (Stat)
• FDA concerns with Abbott test (FDA)
• How US lost 6 weeks (BBC)
• Image credit
• Letters read on TWiV 614
• 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout.
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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• COVID-19 brings out dark side of science (Mother Jones, Wired)
• Jenner Institute COVID-19 vaccine (BioSpace)
• Recombineering (Nucleic Acids Res)
• Vaccines lecture (YouTube)
• ChAdOx1 MERS vaccines protects NHP (Lancet Inf Dis)
• Chimpanzee adenovirus vector (PLoS One)
• Ad-MERS vaccine protects monkeys (NIH)
• Rapid COVID-19 vaccine development (Science)
• Strategic approach to COVID-19 vaccines (Science)
• NIH decision to stop remdesivir study (Stat)
• 80,000 flu deaths this winter (Stat)
• Science and singing (YouTube)
• COVID-19 at choir practice (Emerg Inf Dis)
• 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout.
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.

Hosts: Vincent Racaniello

Guests: Richard Hatchett and Linfa Wang

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Intro music is by Ronald Jenkees.

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Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guests: Daniel Griffin and Michael Schmidt

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• OSHA guidance for dentistry
• COVID0-19 challenges for dentistry (J Dent Res)
• COVID-19 and dentistry (Int J Env Res Pub Health)
• Mouthrinses for dentistry (J Clin Med)
• Disingenuous plandemic documentary (Big Think)
• Letters read on TWiV 611
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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• FDA revises statement on antibody tests (FDA)
• Serology-based tests for SARS-CoV-2 (Center for Health Security)
• ACE inhibitors, ARBs not linked to COVID-19 severity (Mehra study, Mancia study, Reynolds study)
• Global COVID-19 CFR (CEBM)
• Debunking transmission mutation: TWiEVO 55
• Letters read on TWiV 610
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Susan Weiss

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• Coronaviruses by Susan Weiss (YouTube)
• Forty years with coronaviruses (JEM)
• No credible evidence that SARS-CoV-2 came from a lab (Emerg Micr Infect)
• CoV and antagonism of RNAse L (mBio)
• Exoribonuclease needed for MHV innate antagonism (J Virol)
• RNAse L and ADAR (eLife)
• Emerging viruses respiratory award (Amer Lung Assoc)
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

Hosts: Vincent Racaniello and Rich Condit

Guest: Daniel Griffin

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• Pulmonary embolism in COVID-19 (Emerg Inf Dis)
• Patch Study
• Remdesivir in adults with severe COVID-19 (Lancet)
• ACTT remdesivir trial (NIAID)
• Commentary on remdesivir trials (Lancet)
• FDA expected to issue remdesivir EUA (Contaigon Live)
• Recovered COVID-19 patients wrong (Korea Herald)
• Letters read on TWiV 608
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jeff Shaman

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• COVID-19 findings and simulations (Shaman Lab)
• Reconciling diverse estimates of infection rates (pdf)
• Undocumented SARS-CoV-2 infections (Science)
• Simulations of SARS-CoV-2 spread (pdf)
• Repeated infections with diverse CoV (pdf)
• Letters read on TWiV 606
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin

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• Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv)
• Saliva is more sensitve than nasopharyngeal swab (medRxiv)
• NY serological survey results (NY Times)
• FDA caveats on serological tests (FDA)
• Federal guidelines on when to open
• When to open: Roadmap, blog, video explainer
• Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell)
• Lawmakers want human challenge studies (Science)
• Letters read on TWiV 606
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ralph Baric, Mark Heise, and Nat Moorman

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• READDI.org
• CEPI
• DNDi
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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• Nonpathogenic enteroviruses to prevent human disease (pdf)
• OPV for COVID-19 (pdf)
• Enteroviruses to prevent human infections (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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• CpG frequency in SARS-CoV-2 genome (Mol Biol Evol)
• SARS-CoV-2 screening before delivery (NEJM)
• SARS-CoV-2 seroprevalence in Santa Clara (medRxiv)
• SARS-CoV-2 seroprevalence in homeless shelter (NEPR)
• Letters read on TWiV 603
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Stanley Perlman

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• Perlman Laboratory
• An Iowa Caucus of Viruses (TWiV 538)
• Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight)
• T cell responses to respiratory CoV (Immunol Res)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

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• Das Coronavirus podcast
• Identification of SARS-CoV in Germany (NEJM)
• 29 nt deletion in genome of SARS-CoV (Sci Rep)
• 382 nt deletion in genome of SARS-CoV-2 (bioRxiv)
• Virological assessment of COVID-19 patients (Nature)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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• 382 nt deletion in genome of SARS-CoV-2 (bioRxiv)
• Recombination and mutation leading to SARS-CoV-2 (bioRxiv)
• Letters read on TWiV 600
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

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• Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res)
• Tiger at NY zoo positive for SARS-CoV-2 (NY Times)
• IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv)
• Infection fatality rate for managing pandemic (virology blog)
• Image credit
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin MD returns to TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, followed by our coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Vincent Racaniello, Dickson Despommier,Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

Download TWiV 598 (70 MB .mp3, 115 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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• Restricted dispensing of Plaquenil in NY state
• Virology of COVID-19 patients (Nature)
• Susceptibility of domestic animals to SARS-CoV-2 (bioRxiv_
• Cloth face masks for all of US (NY Times)
• Masks and respiratory virus shedding (Nat Med)
• 50 million face masks to Japanese households (Kyodo News)
• More than you want to know about face masks (Slate Star Codex)
• Why is COVID-19 less severe in children? (virology blog)
• Tracking SARS-CoV-2 in sewage (UM)
• 1918 flattening the curve (Nat Geo)
• COVID near you
• Pandemic stops polio eradication (Science)
• SARS-CoV-2 vaccine patch in mice (U Pitt)
• Letters read on TWiV 595
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Immunologist Jon Yewdell joins Vincent and Rich to discuss immune responses in the context of infection with SARS-CoV-2.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jon Yewdell

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Intro music is by Ronald Jenkees.

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TWiV covers trials of hydroxychloroquine and convalescent plasma therapy for COVID-19, and answers listener questions on blood tests for antibodies, cross-protection among coronaviruses, acquiring infection from food or the gas pump, face masks containing copper, and much more.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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• Emergency use of hydroxychloroquine (FDA)
• Trial of hydroxycholorquine in COVID-19 patients (China, France)
• COVID-19 in critically ill patients, Seattle (NEJM)
• Feasibility of convalescent plasma therapy for COVID-19 (medRxiv)
• Letters read on TWiV 596
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2.

Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin, MD

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• Tocilizumab (Wiki)
• Nares swab for SARS-CoV-2 (Star Trib)
• US SARS-CoV-2 epidemic curve (CDC)
• Cleaning and disinfecting (CDC)
• Cleaning fruits and vegetables (FDA)
• Coronavirus food safety (FDA)
• Vaccine development for SARS-CoV-2 (pdf)
• Image by Michele Banks
• Letters read on TWiV 595
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more.

Hosts: Vincent Racaniello

Guest: W. Ian Lipkin

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• Center for Infection and Immunity
• Control the Contagion videos
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Pediatric infectious disease physician and coronavirologist Mark Denison joins Vincent for a discussion of COVID-19 and SARS-CoV-2 with an emphasis on antiviral therapeutics.

Hosts: Vincent Racaniello

Guest: Mark Denison

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Intro music is by Ronald Jenkees.

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A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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• Coronavirus test kit
• Rapid SARS-CoV-2 serological assay (medRxiv)
• Is Dr. Fauci in trouble? (NY Times)
• FDA approves emergency use of convalescent serum (FDA)
• Image by Michele Banks
• Letters read on TWiV 594
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Daniel Griffin joins Ori and the TWiV team an update on the SARS-CoV-2 pandemic, including gastrointestinal illness associated with infection, use of hydroxychloroquine and other antivirals, his experiences treating many patients in the New York area, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Daniel Griffin, Ori Lieberman, and Valeria Cagno

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• Pregnancy and COVID-19 papers (1, 2, 3, 4, 5)
• Second dog infected with SARS-CoV-2 (ProMedMail)
• Italian site with infographic in English
• Image by Michele Banks
• Letters read on TWiV 593
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Ori joins TWiV for an update on the SARS-CoV-2 pandemic, including scary modeling, clinical trials for antivirals and vaccines, asymptomatic transmission, and much more inspired by listener email.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Ori Lieberman

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• Scary modeling (Imperial College London)
• Avigan vs SARS-CoV-2 (NHK)
• SARS-CoV-2 mRNA vaccine (Clinical Trials)
• SARS-CoV-2 stability (NEJM)
• Pediatric COVID-19 (one, two)
• SARS-CoV-2 asymptomatic infection (one, two)
• CDC data on SARS-CoV-2 CFR (MMWR)
• Hydroxycholorquine trial for COVID-19 (Mediterranee-infection)
• Macaque SARS-CoV-2 immunity (bioRxiv)
• Image by Michele Banks
• Letters read on TWiV 591
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Epidemiologist Stephen Morse joins Vincent to discuss epidemiology of SARS-CoV-2 and preparedness for the COVID-19 pandemic.

Hosts: Vincent Racaniello

Guest: Stephen Morse

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Intro music is by Ronald Jenkees.

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Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school.

Hosts: Vincent Racaniello

Guest: Ori Lieberman

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Intro music is by Ronald Jenkees.

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Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ralph Baric

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• Aerosol and surface stability of SARS-CoV-2 (medRxiv)
• Clinical course and risk factors for COVID-19 (Lancet, pdf)
• Face mask use during SARS-CoV outbreak (EID)
• COVID-19 and Italy (Lancet)
• Letters read on TWiV 591
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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The TWiV trio continues in-depth coverage of COVID-19 and SARS-CoV-2, including discussion on genome mutation and circulating lineages, handwashing, facemasks, cruise ship outbreaks, the South Korean situation, and much more.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

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• Stanley Perlman answers CoV questions (Boston Globe)
• Fist bump (Am J Infect Control)
• Joint WHO-China report (pdf)
• Second coronavirus (LA Times)
• Response to second coronavirus (virological.org)
• COVID-19 animal models (STAT)
• Clinical predictors of COVID-19 mortality (Inten Care Med)
• CoV by the numbers (NY Times)
• Contamination of bar soaps (Microbios)
• SARS-CoV-2 vaccine timeline (NPR)
• How new vaccines are developed (GSK)
• SARS among critical care nurses (Emerg Inf Dis)
• How churches prevent SARS-CoV-2 spread (NPR)
• Image credit
• Letters read on TWiV 590
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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Infectious disease physician Daniel Griffin and virologist Valeria Cagno join Vincent to provide updates on the situation with SARS-CoV-2 and COVID-19 in New York and Italy.

Host: Vincent Racaniello

Guests: Daniel Griffin and Valeria Cagno

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Intro music is by Ronald Jenkees.

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Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more.

Hosts: Vincent Racaniello and Rich Condit

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• WHO CoV sitreps
• How to Prepare for the Coronavirus (NY Times)
• Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf)
• Cruise ship a/c could promote virus spread (Purdue news)
• Image credit
• Letters read on TWiV 589
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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• WHO CoV sitreps
• Epidemiology of COVID-19 (China CDC)
• COVID-19 incubation period (J Med Virol)
• China clinical trials for COVID-19 (Nature)
• Furin cleavage site in SARS-CoV-2 spike (virology blog)
• Proximal origin of SARS-CoV-2 (Virological)
• Pangolin photos (Nat Geo)
• Letters read on TWiV 588
• Timestamps by Jolene. Thanks!

Kathy - The deep sea Rich - World's oldest message in a bottle Dickson - Coronavirus: A visual guide Vincent - Recent NSABB meeting Videocasts Day 1 Day 2

Stephen - This podcast will kill you Neva - China's surveillance Sophia - WHO online courses

Intro music is by Ronald Jenkees.

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Vincent and Rich return to the University of Texas Medical Branch at Galveston to speak with Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver about their work on viruses transmitted by mosquitoes and ticks.

Hosts: Vincent Racaniello and Rich Condit

Guests: Dennis Bente, Shannan Rossi, Nikos Vasilakis, and Scott Weaver

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• Measles virus vectored chikungunya vaccine (J Inf Dis)
• World Reference Center for Emerging Viruses and Arboviruses
• Insect-specific alphavirus vaccine vector (Nat Med)
• Legacy of arbovirus hunters (Viruses)
• Electron microscopy for novel arboviruses (Viruses)
• Sylvatic dengue (Am J Trop Med Hyg)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

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In this week's coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China's initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne

Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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• China reacted too slowly to epidemic (NY Times)
• Wuhan rounds up infected (NY Times)
• 2019-nCoV asymptomatic transmission report flawed (Science)
• Mucus reduces effectiveness of alcohol gels (mSphere)
• SARS-CoV in feces (NEJM, Gastroenterology)
• Inadequate plumbing and spread of SARS-CoV (WHO)
• Persistence of virus on surfaces (one, two, three, four)
• Letters read on TWiV 586
• Timestamps by Jolene. Thanks!

Brianne - Mutation, Adaptation, and Virus Genomes Alan - The Comet Rich - Finding Your Roots: Science Pioneers Dickson - Let's Fill Our Cities With Taller, Wooden Buildings Vincent - Twenty-first century plague by Thomas Abraham

Mark - Tracking CoV infections Sophia - Legislative approaches to immunization

Intro music is by Ronald Jenkees.

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The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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• ASV 2020
• Real time tracking of 2019-nCoV (JHU)
• Estimation of 2019-nCoV R0 (Int J Inf Dis)
• WHO Sitreps on 2019-nCoV
• Coronavirus overtakes SARS (SCMP)
• HHS press conference
• Discovery of 2019-nCoV (bioRxiv)
• Rich CoV genes in bats (PLoS Path)
• Early 2019-nCoV transmission dynamics (NEJM)
• Clinical features of early 2019-nCoV patients (Lancet)
• Remdesvir for MERS-CoV (Nat Commun)
• Transmissibility of 2019-nCoV (Imperial Coll, pdf)
• Comparison of R0 of pathogens (Guardian)
• Forecast of 2019-nCoV (WHO, Univ Hong Kong, pdf)
• Quammen on 2019-nCoV (NY Times)
• Benefits of handwashing (NY Times)
• Asymptomatic 2019-CoV transmission (NEJM)
• Summary of TWiV 584
• Surgical vs N95 masks (JAMA)
• Letters read on TWiV 585
• Timestamps by Jolene. Thanks!

Brianne - Pandemic Alan - Educated by Tara Westover Rich - Star Trek: Picard Dickson - Highest Resolution Image Ever Taken of Surface of the Sun Kathy - Scientists make vampire bats 'glow' to simulate vaccine spread Vincent - Virology Lectures 2020

Edward - Virus snowflake designs Anthony - Microbe Hunting Autism to Zika

Intro music is by Ronald Jenkees.

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Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler

Guest: Ralph Baric

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• ASV 2020
• WHO coronavirus sitreps
• CIDRAP article on coronavirus vaccines
• Phylogenetic analysis of 2019-nCoV
• ACE2 is 2019-nCoV receptor (bioRxiv)
• Visual explainer of Huanan market (SCMP)
• Clinical features of 2019-nCoV patients (Lancet)
• Familial cluster of pneumonia caused by 2019-nCoV (Lancet)
• SARS-CoV 29 nt deletion reduces replication (Sci Rep)
• NSABB
• 2019 TWiV World Tour t-shirt
• Letters read on TWiV 584
• Timestamps by Jolene. Thanks!

Alan - Library plug-in for Firefox or Chrome Rich - Sounds of the Solar Wind (Parker Solar Probe) Dickson - Stunning wildlife photos Kathy - Incomplete list of things that blow the minds of intro bio students Vincent - Mosquito photographs by Alex Wild (and anti-pick)

Justin - YadaYadaYada virus

Intro music is by Ronald Jenkees.

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Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters.

Hosts: Vincent Racaniello and Rich Condit

Guests: Jim LeDuc, Tom Ksiazek, and Bob Tesh

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Intro music is by Ronald Jenkees.

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TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.

Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email

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• ASV 2020
• NJ ready to remove religious vaccine exemptions (Patch)
• New virus causing pneumonia in China (NY Times)
• New China virus is coronavirus (NY Times, ProMedMail)
• Weekly influenza cases (CDC)
• Future of influenza vaccines (Vaccines)
• Household influenza vaccine study (Int J Epidemiol)
• African swine fever (USDA)
• African swine fever infographics (one, two)
• Race for African swine fever vaccine (Scientist)
• 3D structure of African swine fever virus (J Biol Chem)
• Letters read on TWiV 582
• Timestamps by Jolene. Thanks!

Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information Dickson - Australia Fires; Insect ecology; Smoke and aerosols Kathy - runcible Vincent - Without a Vaccine, These Are Your Odds

Intro music is by Ronald Jenkees.

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